Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Nancy K. Valego"'
Autor:
Nancy K. Valego, Lijun Tang, Mark C. Chappell, James C. Rose, Stephen Contag, Jianli Bi, Luke C. Carey
Publikováno v:
Journal of the Renin-Angiotensin-Aldosterone System, Vol 14 (2013)
Antenatal corticosteroid exposure reduces renal function and alters the intrarenal renin-angiotensin system to favor angiotensin activation of angiotensin type 1 receptor (AT1R) mediated responses in ovine offspring. This study aimed to assess whethe
Autor:
Nancy K. Valego, James C. Rose
Publikováno v:
Reproductive Sciences. 17:477-486
Corticotropin releasing hormone (CRH) has been detected in the adrenal gland of many species and may be involved in regulation of glucocorticoid secretion. In cultured human fetal adrenal definitive/transitional zone cells, CRH upregulates the adreno
Autor:
Lijun Tang, Nancy K. Valego, Mark C. Chappell, Philip Deibel, James C. Rose, Jianli Bi, Luke C. Carey, James Perrott, Xiurong Sun, Jorge P. Figueroa
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 296:R309-R317
Exposure to clinically relevant doses of glucocorticoids during fetal life increases blood pressure in adult male and female sheep. The purpose of this study was to evaluate the effects of prenatal exposure to betamethasone at 80–81 days of gestati
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 293:R701-R706
Previous studies have suggested that thyroid hormone influences maturation of the renin-angiotensin system (RAS) and cardiovascular function in the late-gestation fetal sheep. To further examine the importance of thyroid hormone in this regard, we us
Publikováno v:
Journal of the Society for Gynecologic Investigation. 13:604-609
BACKGROUND AND OBJECTIVES Activity of the fetal renin-angiotensin system (RAS) is developmentally regulated, increasing in late gestation toward term. Thyroid hormone and the renal nerves are both important modulators of renal RAS maturation; however
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 291:E214-E220
The late-gestation plasma cortisol surge in the sheep fetus is critical for stimulating organ development and parturition. Increased adrenal responsiveness is one of the key reasons for the surge; however, the underlying mechanisms are not fully unde
Autor:
Sharla F. Young, Jinjuan Wang, Stephen B. Tatter, Nancy K. Valego, Luke C. Carey, Yixin Su, James C. Rose
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 289:R410-R417
Although it has been recognized for over a decade that hypothalamic-pituitary disconnection (HPD) in fetal sheep prevents the late gestation rise in plasma cortisol concentrations, the underlying mechanisms remain unclear. We hypothesized that reduct
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 288:R1279-R1287
The activity of the renin-angiotensin system (RAS) increases significantly in the late-gestation fetal sheep. Fetal cortisol is also increased during this time, and it is thought that the increase in cortisol may modulate the RAS changes. Previous st
Publikováno v:
Journal of the Society for Gynecologic Investigation. 11:27-35
Maturation of adrenocortical function is important because a prepartum increase in fetal plasma glucocorticoids is required for survival after birth. Adrenal maturation may include alterations in the regulation of adrenocorticotropic hormone (ACTH) r
Autor:
Jalonda Thompson, Stephen B. Tatter, Jorge P. Figueroa, Nancy K. Valego, James C. Rose, Sharla F. Young
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 284:R1621-R1630
Corticotropin-releasing hormone receptor type 1 (CRH-R1) expression 1 and vasopressin type 1b (V1b) receptor protein decrease in late-gestation fetal sheep. Because hypothalamo-pituitary disconnection (HPD) has been demonstrated to prevent the morpho