Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nancy K. Hopkins"'
Autor:
John N. van den Anker, Gail L. Jungbluth, Nancy K. Hopkins, Jon B. Bruss, Rosie P. Grzebyk, Susan M. Abdel-Rahman, Ian R Welshman, Gregory L. Kearns
Publikováno v:
Clinical Pharmacology & Therapeutics. 74:413-422
The impact of age on linezolid disposition during the first few months of life has not been previously investigated. We characterized linezolid pharmacokinetics after a single, 10.0-mg/kg intravenous dose in 42 infants stratified as follows: group 1
Autor:
Gail L. Jungbluth, Michael E. Brier, Donald H. Batts, Margaret O'Grady, Nancy K. Hopkins, Dennis J. Stalker, George R. Aronoff, Kristi K. Ryan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:2775-2780
Linezolid is a member of a new, unique class of synthetic antibacterial agents called oxazolidinones that are effective against gram-positive bacteria, including vancomycin-resistant organisms. We tested the hypothesis that the linezolid clearance wo
Publikováno v:
European Journal of Clinical Pharmacology. 57:793-797
Objective: To evaluate the possible effects of age and sex on the pharmacokinetics of linezolid in healthy volunteers. Methods: A single 600-mg dose of linezolid was administered orally to young (18–40 years) and elderly (≥65 years) healthy males
Autor:
Donald H. Batts, Wang-Pui Sheu, Nancy K. Hopkins, Kirsteen M. Donaldson, Pamela E. Hendershot, Edward J. Antal
Publikováno v:
The Journal of Clinical Pharmacology. 41:552-562
The primary objective of this study was to compare the effects of oral linezolid with moclobemide and placebo on the pressor response to oral tyramine. Secondary objectives were to determine possible mechanisms of the effect based on changes in the p
Publikováno v:
Biopharmaceutics & Drug Disposition. 22:91-97
Linezolid is a novel oxazolidinone antibiotic that has a spectrum of activity encompassing a variety of Gram-positive bacteria. The objectives of this study were twofold: (1) to compare the absorption of linezolid tablets given immediately following
Publikováno v:
The Journal of Clinical Pharmacology. 39:1277-1282
Linezolid, a new oxazolidinone antimicrobial agent, has a spectrum of activity encompassing a wide variety of Grampositive bacteria. The purpose of this study was to evaluate the pharmacokinetics of linezolid and aztreonam, an antimicrobial agent wit
Publikováno v:
Contraception. 60:209-214
The steady-state pharmacokinetics and pharmacodynamics of medroxyprogesterone acetate (MPA) and estradiol (E2, released from E2C by esterase enzymes) were characterized after administration to surgically sterile women. This report describes the pharm
Publikováno v:
Contraception. 60:201-208
A new contraceptive option, medroxyprogesterone acetate (MPA) and estradiol cypionate (E2C) (MPA/E2C, Lunelle Monthly Contraceptive Injection), will soon be available for women in the US. This article reports the results of a US trial that assessed t
Autor:
Joseph C. Fleishaker, Nancy K. Hopkins, Paul G. Pearson, Laura K. Pearson, Gary Peters, Larry C. Wienkers
Publikováno v:
The Journal of Clinical Pharmacology. 39:260-267
This study assessed whether the previously reported difference in tirilazad clearance between pre- and postmenopausal women is reversed by hormone replacement and whether this observation can be explained by differences in CYP3A4 activity. Ten health
Publikováno v:
The Pediatric infectious disease journal. 22
There are a number of physiologic and developmental differences between children and adults that can influence the absorption, distribution, metabolism and elimination of a drug. Therefore it is important to determine the specific pharmacokinetic cha