Výsledky vyhledávání - "Nancy K. Harn"

A ?-turn mimic and a thiomethylene dipeptide surrogate employed in the study of cyclic peptide RGD and RCD cell-adhesion inhibitors

Autor: Pina M. Cardarelli, Shiu-Lan Chiang, Christy Mikos, Nancy Delaet, Gilbert M. Rishton, Cripps Stephan James, Mary A. Moscinski, Sharon M. Walker, Nancy K. Harn, Frank Gorcsan, Thomas J. Lobl

Publikováno v: Letters in Peptide Science. 3:37-44

During an inflammatory response, leukocytes adhere to the blood-vessel wall and to underlying extracellular matrix-protein fibronectin via noncovalent interaction through two distinct cell-surface integrins, α5β1 and α4β1. An Arg-Gly-Asp tripepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::061b8ae080e46fe4b44516b55669c06e
https://doi.org/10.1007/bf00131084

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Arg-Gly thiomethylene dipeptide surrogates: Synthesis and incorporation into Arg-Gly-Asp pseudotripeptides

Autor: Cripps Stephan James, Gilbert M. Rishton, Nancy K. Harn

Publikováno v: Tetrahedron Letters. 35:1389-1392

A synthesis of Arg-Gly thiomethylene dipeptide surrogates and the incorporation of these surrogates into Arg-Gly-Asp type pseudotripeptides are described. These compounds are potentially useful for the preparation of small nonpeptide Arg-Gly-Asp pept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c5e96cfe81936129b529c01c267f06a
https://doi.org/10.1016/s0040-4039(00)76226-5

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ChemInform Abstract: Arg-Gly Thiomethylene Dipeptide Surrogates: Synthesis and Incorporation into Arg-Gly-Asp Pseudotripeptides

Autor: Cripps Stephan James, Gilbert M. Rishton, Nancy K. Harn

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4219c54ae4ed7b74bf34d1e48f03ad54
https://doi.org/10.1002/chin.199428256

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Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential

Autor: Mitsunobu Hara, Timothy Alan Grese, Rieko Tanaka, Almudena Rubio, Shinji Nara, Shiro Akinaga, Takashi Kuwabara, Yutaka Kanda, Jun Eishima, Nobuyuki Yoda, Nancy K. Harn, Rui Ohashi, Shiro Soga, Douglas Linn Gernert

Publikováno v: Bioorganicmedicinal chemistry. 15(3)

The design and synthesis of a novel piperidine series of farnesyltransferase (FTase) inhibitors with reduced potential for metabolic glucuronidation are described. The various substitution and exchange of the phenyl group at the C-2 position of the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b2a851daa574a25881a4ebed7f9d62
https://pubmed.ncbi.nlm.nih.gov/17127066

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Facile catalytic methods for intermolecular generation of allylic oxonium ylides and their stereoselective [2,3]- sigmatropic rearrangement

Autor: Vahid Bagheri, Michael P. Doyle, Nancy K. Harn

Publikováno v: Tetrahedron Letters. 29:5119-5122

Allylic oxonium ylides, generated by rhodium(II) acetate-catalyzed decomposition of diazo carbonyl compounds in the presence of allyl methyl ethers, undergo the [2,3]-sigmatropic rearrangement with a high degree of diastereoselectivity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3b9e2a170f23c86e6c66a0bc600b2a2
https://doi.org/10.1016/s0040-4039(00)80695-4

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ChemInform Abstract: Facile Catalytic Methods for Intermolecular Generation of Allylic Oxonium Ylides and Their Stereoselective (2,3)-Sigmatropic Rearrangement

Autor: Nancy K. Harn, Michael P. Doyle, Vahid Bagheri

Publikováno v: ChemInform. 20

The E-configurated allylic methyl ethers (I) are coupled with the α-diazocarbonyl compounds (II) in the presence of dirhodium tetraacetate to give the diastereomeric γ,δ-unsaturated α-methoxy carbonyl compounds (III) and (IV) with predominance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e30f6889e65c7dd626e0e48741e2858
https://doi.org/10.1002/chin.198916242

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