Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Nancy J. Vogelaar"'
Autor:
Keane J. Dye, Nancy J. Vogelaar, Megan O’Hara, Pablo Sobrado, Webster Santos, Paul R. Carlier, Zhaomin Yang
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT With the pressing antibiotic resistance pandemic, antivirulence has been increasingly explored as an alternative strategy against bacterial infections. The bacterial type IV pilus (T4P) is a well-documented virulence factor and an attractive
Externí odkaz:
https://doaj.org/article/4c05d73fe5684cdb8db1f193e97bcb71
Publikováno v:
mSphere, Vol 6, Iss 2 (2021)
Many bacterial pathogens use their type IV pili (T4P) to facilitate and maintain infection of a human host. Small chemical compounds that inhibit the production or assembly of T4P have promise in the treatment and prevention of infections, especially
Externí odkaz:
https://doaj.org/article/4cb177181c3544439641c6b5decdb39a
Autor:
Paul Velander, Richard F. Helm, Ling Wu, Bin Xu, Nancy J. Vogelaar, Biswarup Mukhopadhyay, Shijun Zhang, Sherry B. Hildreth
Publikováno v:
Pharmacol Res
Background: A range of neurodegenerative and related aging diseases, such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes, are linked to toxic protein aggregation. Yet the mechanisms of protein aggregation inhibition by small mol
Publikováno v:
mSphere, Vol 6, Iss 2 (2021)
mSphere
mSphere
The bacterial type IV pilus (T4P) is a prominent virulence factor in many significant human pathogens, some of which have become increasingly antibiotic resistant. Antivirulence chemotherapeutics are considered a promising alternative to antibiotics
Autor:
Richard F. Helm, Nancy J. Vogelaar, Bin Xu, Paul Velander, Sherry B. Hildreth, Ling Wu, Shijun Zhang, Biswarup Mukhopadhyay
Mechanisms of amyloid inhibition remains poorly understood, in part because most protein targets of amyloid assembly are partially unfolded or intrinsically disordered, which hinders detailed structural characterization of protein-inhibitor complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad05cfa264324acd3fe857a3bb49be06
https://doi.org/10.1101/2020.10.08.873620
https://doi.org/10.1101/2020.10.08.873620
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
Aspergillus fumigatus is an opportunistic human pathogen responsible for deadly, invasive infections in immunocompromised patients. The A. fumigatus cell wall is a complex network of polysaccharides among them galactofuran, which is absent in humans.
Autor:
Nancy J. Vogelaar, Julia S. Martin del Campo, Pablo Sobrado, Karina Kizjakina, Karishma Tolani, Kim Harich
Publikováno v:
ACS chemical biology. 11(11)
Aspergillus fumigatus is an opportunistic fungal pathogen and the most common causative agent of fatal invasive mycoses. The flavin-dependent monooxygenase siderophore A (SidA) catalyzes the oxygen and NADPH dependent hydroxylation of l-ornithine (l-
Publikováno v:
Biochemistry. 49:5870-5879
Pseudomonas aeruginosa, like many Gram-negative bacterial pathogens, requires its type III secretion system (T3SS) to facilitate acute infections. In P. aeruginosa, the expression of all T3SS-related genes is regulated by the transcriptional activato
Publikováno v:
Protein Science. 18:503-513
The opportunistic pathogen P. aeruginosa utilizes a type III secretion system (T3SS) to support acute infections in predisposed individuals. In this bacterium, expression of all T3SS-related genes is dependent on the AraC-type transcriptional activat
Autor:
Nancy J. Vogelaar, Qian Han, Jianyong Li, Scott R. Wilson, Howard Robinson, Yi Gui Gao, Menico Rizzi
Publikováno v:
Journal of Biological Chemistry. 281:37175-37182
Mosquitoes are unique in having evolved two alanine glyoxylate aminotransferases (AGTs). One is 3-hydroxykynurenine transaminase (HKT), which is primarily responsible for catalyzing the transamination of 3-hydroxykynurenine (3-HK) to xanthurenic acid