Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nancy J. Leidenheimer"'
Autor:
Erika L. Knott, Nancy J. Leidenheimer
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8485 (2020)
Adrenocortical carcinoma (ACC) is a rare but deadly cancer for which few treatments exist. Here, we have undertaken a targeted bioinformatics study of The Cancer Genome Atlas (TCGA) ACC dataset focusing on the 30 genes encoding the γ-aminobutyric ac
Externí odkaz:
https://doaj.org/article/cf8510fc8e3048ca84c06b4e1688f95f
Autor:
Nancy J. Leidenheimer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
The functional unit for inter-neuronal communication in the central nervous system is the neuronal synapse. The number of postsynaptic neurotransmitter receptors at the cell surface is an important determinant of synaptic efficacy and plasticity. A d
Externí odkaz:
https://doaj.org/article/e24e02eeb68d465b9f142fcfd974dc5f
Autor:
Nancy J. Leidenheimer, Erika L. Knott
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8485, p 8485 (2020)
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8485, p 8485 (2020)
Adrenocortical carcinoma (ACC) is a rare but deadly cancer for which few treatments exist. Here, we have undertaken a targeted bioinformatics study of The Cancer Genome Atlas (TCGA) ACC dataset focusing on the 30 genes encoding the &gamma
aminob
aminob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c9b83a866a40173d4b99b72cc1fb22
http://europepmc.org/articles/PMC7697095
http://europepmc.org/articles/PMC7697095
Autor:
Nancy J. Leidenheimer, Erika L. Knott
Publikováno v:
Cancer Research. 81:2408-2408
Unsupervised analysis of γ-aminobutyric acid (GABA) system genes has identified some genes as correlated with indicators of severity in several cancers. Central to GABA system function is the GABA shunt, a series of reactions bypassing two steps of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85a006975acf713ee7d78f8ebe8031bb
https://doi.org/10.1158/1538-7445.am2021-2408
https://doi.org/10.1158/1538-7445.am2021-2408
Autor:
Nancy J. Leidenheimer, Erika L. Knott
Publikováno v:
Cancer Research. 80:4401-4401
The gamma-aminobutyric acid (GABA) system is evolutionarily conserved and, in mammals, is comprised of 30 genes encoding 4 enzymes, 21 receptor subunits, and 5 transporters. The GABA system has primarily been studied for its role in inhibitory neurot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d0b252b49469450407f20da1c2bb5a3
https://doi.org/10.1158/1538-7445.am2020-4401
https://doi.org/10.1158/1538-7445.am2020-4401
Autor:
Erika L. Knott, Loren L. Looger, Nancy J. Leidenheimer, Jonathan S. Marvin, Yoshiteru Shimoda, Marco Leite, Vincent Magloire, Ilya Kolb, Kaspar Podgorski, Dmitri A. Rusakov, Ondrej Novak, Takashi Kawashima, Dimitri M. Kullmann, Thomas P. Jensen, Misha B. Ahrens
Publikováno v:
Nature methods. 16(8)
Current techniques for monitoring GABA (γ-aminobutyric acid), the primary inhibitory neurotransmitter in vertebrates, cannot follow transients in intact neural circuits. To develop a GABA sensor, we applied the design principles used to create the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f23846212b6e82302707d031bed6d96
https://pubmed.ncbi.nlm.nih.gov/31308547
https://pubmed.ncbi.nlm.nih.gov/31308547
Autor:
Nancy J. Leidenheimer, Misha B. Ahrens, Takashi Kawashima, Jonathan S. Marvin, Thomas P. Jensen, Dimitri M. Kullmann, Kaspar Podgorski, Erika L. Knott, Dmitri A. Rusakov, Loren L. Looger, Yoshiteru Shimoda, Marco Leite, Vincent Magloire, Ondrej Novak
Current techniques for monitoring GABA, the primary inhibitory neurotransmitter in vertebrates, cannot follow ephemeral transients in intact neural circuits. We applied the design principles used to create iGluSnFR, a fluorescent reporter of synaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9411690f240827ee530f270383dbedd
Autor:
Nancy J, Leidenheimer
Publikováno v:
Handbook of experimental pharmacology. 245
Pharmacological chaperones (PCs) are small molecules that bind to nascent protein targets to facilitate their biogenesis. The ability of PCs to assist in the folding and subsequent forward trafficking of disease-causative protein misfolding mutants h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccbb7d33d253c232bfaa19e43b4e1e69
https://pubmed.ncbi.nlm.nih.gov/29071508
https://pubmed.ncbi.nlm.nih.gov/29071508
Publikováno v:
Pharmacological Research. 83:10-19
Approximately forty percent of diseases are attributable to protein misfolding, including those for which genetic mutation produces misfolding mutants. Intriguingly, many of these mutants are not terminally misfolded since native-like folding, and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f938b27618aa726ae4acbfeae3505c1
https://doi.org/10.1016/j.phrs.2014.01.005
https://doi.org/10.1016/j.phrs.2014.01.005
Publikováno v:
Cancer Research. 79:4379-4379
Although an upregulation of aerobic glycolysis (the Warburg effect) is a canonical hallmark of cancer, it is now recognized that most cancerous cells continue to rely on the TCA cycle as a source of both biosynthetic precursors (DeBarardinis & Chande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82f46c0cc4155c0deee1fe9040d0026c
https://doi.org/10.1158/1538-7445.am2019-4379
https://doi.org/10.1158/1538-7445.am2019-4379