Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nancy J. Bump"'
Autor:
Kara Hoar, Jiejin Chen, Sean J. Harrison, Jingya Ma, James M. Gavin, Neil F. Bence, Wei Chen, Ping Li, Michael Sintchak, Nancy J. Bump, Qing Xu, Lawrence R. Dick, William D. Mallender, Jesse J. Chen, Alexandra E. Gould, Frank Bruzzese, Yafang Lin
Publikováno v:
Journal of Biological Chemistry. 289:22648-22658
E1 enzymes activate ubiquitin or ubiquitin-like proteins (Ubl) via an adenylate intermediate and initiate the enzymatic cascade of Ubl conjugation to target proteins or lipids. Ubiquitin-fold modifier 1 (Ufm1) is activated by the E1 enzyme Uba5, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6849a9cf4d33b291a3a2b8282c7b575a
https://doi.org/10.1074/jbc.m114.573972
https://doi.org/10.1074/jbc.m114.573972
Autor:
John Newcomb, James M. Gavin, Nancy J. Bump, Stephen Tirrell, Lawrence R. Dick, Saurabh Menon, Jessica Huck, Petter Veiby, Benjamin S. Amidon, Yu Yang, Marc L. Hyer, Paul D. Greenspan, Fleming Paul E, Teresa A. Soucy, Jim Brownell, Michael Sintchak, Josh Powe, Steve Langston, Mark Manfredi, Judy Shi, Jeff Ciavarri, Darshan S. Sappal, Frank Bruzzese, Mike Kuranda, Katherine Galvin, Michael Milhollen, Ping Li, Neil F. Bence, Jing Tao Wu, Claudia Rabino, Chris Claiborne, Tary Traore, Jennifer Duffy, Jessica Riceberg, Robert J. Griffin, Kara Hoar, Anya Lublinsky, Bradley Stringer, Sai M Pulukuri
Publikováno v:
Nature medicine. 24(2)
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2e77aca37457d7e649a61cfd0e086b
https://pubmed.ncbi.nlm.nih.gov/29334375
https://pubmed.ncbi.nlm.nih.gov/29334375
Autor:
Joanne Kamens, Julia Janzen, Andres Salmeron, Yasmina Soneji, Nancy J. Bump, Hamish Allen, Steven C. Ley
Publikováno v:
Journal of Biological Chemistry. 276:22215-22222
The p105 precursor protein of NF-kappaB1 acts as an NF-kappaB inhibitory protein, retaining associated Rel subunits in the cytoplasm of unstimulated cells. Tumor necrosis factor alpha (TNFalpha) and interleukin-1alpha (IL-1alpha) stimulate p105 degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358afdfc9a771b4db913e169f51cf6e9
https://doi.org/10.1074/jbc.m101754200
https://doi.org/10.1074/jbc.m101754200
Autor:
Robert V. Talanian, Hiromi Kojima, Ralph R. Weichselbaum, Nancy J. Bump, Donald Kufe, Rakesh Datta, Emad S. Alnemri, David Banach, Winnie W. Wong
Publikováno v:
Journal of Biological Chemistry. 272:1965-1969
The response of eukaryotic cells to ionizing radiation (IR) includes induction of apoptosis. However, the signals that regulate this response are unknown. The present studies demonstrate that IR treatment of U-937 cells is associated with: (i) intern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff062e65ebb866503a1c24eb2abf7c3
https://doi.org/10.1074/jbc.272.3.1965
https://doi.org/10.1074/jbc.272.3.1965
Autor:
Peter Licari, Kenneth D. Brady, Ping Li, Lois K. Miller, Catherine R. Ferenz, John A. Mankovich, Margaret Hugunin, Arnold H. Greenberg, Nancy J. Bump, Somasekar Seshagiri, Patrick Chen, Simon Franklin, Lianfa Shi, Tariq Ghayur, Maria Hackett, Winnie W. Wong
Publikováno v:
Science. 269:1885-1888
The baculovirus antiapoptotic protein p35 inhibited the proteolytic activity of human interleukin-1 beta converting enzyme (ICE) and three of its homologs in enzymatic assays. Coexpression of p35 prevented the autoproteolytic activation of ICE from i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27081c71c1639bfff6ed39a61cdbfb5
https://doi.org/10.1126/science.7569933
https://doi.org/10.1126/science.7569933
Autor:
Nigel Walker, M. Terranova, Robert V. Talanian, Nancy J. Bump, Tariq Ghayur, Daniel E. Tracey, John A. Mankovich, A. Möller, W. Houy, E. Orlewicz, Margaret Hugunin, A. Summani, Robert Kamen, Winnie W. Wong, C.A. Pratt, L.D. Hammill, Simon Franklin, L.C. Dang, C.R. Ferenza, J.P. Welch, Kenneth Dale Brady, Maria Hackett, L. McGuiness, Michael Paskind, Linda Herzog, Pedro Reis, L. Xiong
Publikováno v:
Cell. 78:343-352
Interleukin-1β-converting enzyme (ICE) proteolytically cleaves pro-IL-1β to its mature, active form. The crystal structure at 2.5 A resolution of a recombinant human ICE-tetrapeptide chloromethylketone complex reveals that the holoenzyme is a homod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1370afb27876246431c4c17a1a11f3e7
https://doi.org/10.1016/0092-8674(94)90303-4
https://doi.org/10.1016/0092-8674(94)90303-4
Autor:
Matthew O. Duffey, Tricia J. Vos, Ruth Adams, Jennifer Alley, Justin Anthony, Cynthia Barrett, Indu Bharathan, Douglas Bowman, Nancy J. Bump, Ryan Chau, Courtney Cullis, Denise L. Driscoll, Amy Elder, Nancy Forsyth, Jonathan Frazer, Jianping Guo, Luyi Guo, Marc L. Hyer, David Janowick, Bheemashankar Kulkarni, Su-Jen Lai, Kerri Lasky, Gang Li, Jing Li, Debra Liao, Jeremy Little, Bo Peng, Mark G. Qian, Dominic J. Reynolds, Mansoureh Rezaei, Margaret Porter Scott, Todd B. Sells, Vaishali Shinde, Qiuju Judy Shi, Michael D. Sintchak, Francois Soucy, Kevin T. Sprott, Stephen G. Stroud, Michelle Nestor, Irache Visiers, Gabriel Weatherhead, Yingchun Ye, Natalie D’Amore
Publikováno v:
Journal of medicinal chemistry. 55(1)
This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71360d15b44c1a6fcfa39401ef5e4fbf
https://pubmed.ncbi.nlm.nih.gov/22070629
https://pubmed.ncbi.nlm.nih.gov/22070629
Autor:
Andrew I. Gagnon, Joanne Kamens, Hamish Allen, Jennifer Hardman, Kevin M. Clark, Neil Wishart, Nancy J. Bump, Anca Clabbers, Medha J. Tomlinson, Yong Jia, Christopher M. Quinn
Publikováno v:
Archives of biochemistry and biophysics. 441(1)
Cancer osaka thyroid (COT), a human MAP 3 K, is essential for lipopolysaccharide activation of the Erk MAPK cascade in macrophages. COT 30--467 is insoluble, whereas low levels of COT 30--397 can be expressed, but this protein is unstable. However, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e0d7422e5d9600479d6fd7675a7bbf
https://pubmed.ncbi.nlm.nih.gov/16087150
https://pubmed.ncbi.nlm.nih.gov/16087150
Autor:
Michele Terranova, Robert V. Talanian, John A. Mankovich, Tariq Ghayur, Margaret Hugunin, Maria Hackett, Nancy J. Bump, Cynthia Johnston, Michael Paskind, Joanne Kamens, Hamish Allen, David Banach, Ping Li
Publikováno v:
The Journal of biological chemistry. 270(25)
Interleukin-1 beta converting enzyme (ICE) is a cytoplasmic cysteine protease required for generating the bioactive form of the interleukin-1 beta cytokine from its inactive precursor. We report the identification of ICH-2, a novel human gene encodin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f112269d4978849da1196f9c4e533039
https://pubmed.ncbi.nlm.nih.gov/7797510
https://pubmed.ncbi.nlm.nih.gov/7797510
Publikováno v:
Molecular and cellular biochemistry. 92(1)
The purification and characteristics of purified HL60 tuftsin receptors are described. Purification was accomplished by affinity chromatography similar to that described earlier, wherein a tuftsin analog Thr-Lys-Pro-Pro-Arg, is covalently linked at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170151dc0279a14a3508b76119ee7fa3
https://pubmed.ncbi.nlm.nih.gov/2308578
https://pubmed.ncbi.nlm.nih.gov/2308578