Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nancy I. Hutchinson"'
Autor:
Michael W. Lark, Jorge O. Galante, Joshua J. Jacobs, Lori A. Hoerrner, Katalin Mikecz, Jianling Yao, Tibor T. Glant, Klaus E. Kuettner, Nancy I. Hutchinson
Publikováno v:
Journal of Bone and Mineral Research. 10:1417-1427
Periprosthetic osteolysis with or without aseptic loosening is a major clinical problem in total hip arthroplasty. While the macrophage response to prosthetic wear debris and its role in periprosthetic osteolysis has been extensively studied, informa
Autor:
Irwin I. Singer, John G. Flanagan, Nicole A. Chartrain, A. J. Forsyth, Howard Y. Chen, C. F. Shen, Ellen K. Bayne, Denise M. Visco, John S. Mudgett, Karla Stevens, Myrna E. Trumbauer, Douglas W. Kawka, Nancy I. Hutchinson, Joseph McDonnell
Publikováno v:
Arthritis & Rheumatism. 41:110-121
Objective It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This hypothesis was tested by examining the art
Autor:
David A. Geller, Ermenegilda McCauley, Michael J. Tocci, Timothy R. Billiar, Malcolm MacCoss, Andreas K. Nussler, Stephan K. Grant, Kenny K. Wong, Jimmy R. Calaycay, Theresa M. Kelly, Jeffrey R. Weidner, Patrick R. Griffin, S.M. Raju, Tracey Klatt, Shrenik K. Shah, Hongbo Qi, Richard A. Mumford, Gloria C. Wolfe, Hollis R. Williams, John A. Schmidt, Nancy I. Hutchinson, Karen L. MacNaul
Publikováno v:
Journal of Biological Chemistry. 271:28212-28219
Recombinant human inducible nitric-oxide synthase (rH-iNOS) was expressed in the baculovirus system and purified by a novel immunoaffinity column. rH-iNOS and its native counterpart from cytokine-stimulated primary hepatocytes exhibited similar molec
Publikováno v:
Journal of Biological Chemistry. 271:22679-22686
All three mammalian isoforms of nitric oxide synthase (NOS) must bind calmodulin (CaM) for enzymatic activity. Only NOS2 (the inducible isoform, iNOS) does so at the low levels of free Ca2+ in resting cells and when almost all Ca2+ is chelated in cel
Autor:
Myrna E. Trumbauer, Daniel S. Fletcher, Karen Sokol, Qiao-wen Xie, Gary J Hom, Carl Nathan, Karla Stevens, John D. MacMicking, Nicole A. Chartrain, John S. Mudget, Nancy I. Hutchinson, Howard Y. Chen
Publikováno v:
Cell. 81(4):641-650
Mice deficient in inducible nitric oxide synthase (iNOS) were generated to test the idea that !NOS defends the host against infectious agents and tumor cells at the risk of contributing to tissue damage and shock. iNOS -I- mice failed to restrain the
Autor:
John S. Mudgett, N F Sitrin, Nancy I. Hutchinson, Patrick P. Koty, Nicole A. Chartrain, Eric P. Hoffman, Andreas K. Nussler, T R Billiar, David A. Geller
Publikováno v:
Journal of Biological Chemistry. 269:6765-6772
Nitric oxide, a multifunctional effector molecule synthesized by nitric oxide synthase (NOS) from L-arginine, conveys signals for vasorelaxation, neurotransmission, and cytotoxicity. Three different NOS isoforms have been identified which fall into t
Autor:
Susan Donatelli, Vernon L. Moore, Lori A. Hoerrner, Ellen K. Bayne, Nancy I. Hutchinson, Michael W. Lark, Coral Harper, Joseph McDonnell, Karen L. MacNaul
Publikováno v:
Arthritis & Rheumatism. 35:1227-1233
Objective. To examine the in vivo expression of the matrix metalloproteinase stromelysin in the synovium and articular cartilage of rabbits injected intraarticularly with recombinant human interleukin-1β (IL-1). Methods. The direct isolation of mess
Autor:
Michael W. Lark, Lori A. Walakovits, Coral Harper, Susan Donatelli, Ellen K. Bayne, Vernon L. Moore, Patricia M. Cameron, Karen L. MacNaul, Nancy I. Hutchinson
Publikováno v:
Matrix. 12:173-184
One of the best studied animal models of osteoarthritis is a dog model in which the anterior cruciate ligament of the hind limb stifle joint is transected (Pond-Nuki model). To determine whether stromelysin might play a role in this model, it was nec
Autor:
Nancy I. Hutchinson, Michael J. Tocci, Karen L. MacNaul, Nicole A. Chartrain, Michael W. Lark
Publikováno v:
Journal of Biological Chemistry. 265:17238-17245
Primary and passaged human synovial fibroblasts isolated from rheumatoid pannus were treated with recombinant interleukin-1 (IL-1) alpha or beta, tumor necrosis factor-alpha (TNF), or phorbol myristate acetate (PMA) to determine the effects of these
Autor:
John W. Kozarich, Renee M. Chabin, Ermenegilda McCauley, John A. Schmidt, Sayyaparaju Madhusudanaraju, Nancy I. Hutchinson, Karen L. MacNaul, Gloria C. Wolfe, Kenny K. Wong, Jimmy R. Calaycay, Theresa M. Kelly
Publikováno v:
Biochemistry. 35(29)
Nitric oxide synthase catalyzes the pyridine nucleotide-dependent oxidation of L-arginine to nitric oxide and L-citrulline. It is a specialized cytochrome P450 monooxygenase that is sensitive to inhibition by imidazole. Steady-state kinetic studies o