Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Nancy Holroyd"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Nematodes are important parasites of people and animals, and in natural ecosystems they are a major ecological force. Strongyloides ratti is a common parasitic nematode of wild rats and we have investigated its population genetics using sing
Externí odkaz:
https://doaj.org/article/79b03bbda6ea416fb6fecb3eb75b707b
Autor:
Michaela Herz, Magdalena Zarowiecki, Leonie Wessels, Katharina Pätzel, Ruth Herrmann, Christiane Braun, Nancy Holroyd, Thomas Huckvale, Monika Bergmann, Markus Spiliotis, Uriel Koziol, Matthew Berriman, Klaus Brehm
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
The lethal zoonosis alveolar echinococcosis is caused by tumour-like growth of the metacestode stage of the tapeworm Echinococcus multilocularis within host organs. We previously demonstrated that metacestode proliferation is exclusively driven by so
Externí odkaz:
https://doaj.org/article/bdde70f3053a478896131bb28ac498c5
Autor:
Avril Coghlan, Frederick A Partridge, María Adelaida Duque-Correa, Gabriel Rinaldi, Simon Clare, Lisa Seymour, Cordelia Brandt, Tapoka T Mkandawire, Catherine McCarthy, Nancy Holroyd, Marina Nick, Anwen E Brown, Sirapat Tonitiwong, David B Sattelle, Matthew Berriman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011205 (2023)
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for oth
Externí odkaz:
https://doaj.org/article/a9399883925e4c239ce6cfe85ef5286d
Autor:
María A. Duque-Correa, David Goulding, Faye H. Rodgers, J. Andrew Gillis, Claire Cormie, Kate A. Rawlinson, Allison J. Bancroft, Hayley M. Bennett, Magda E. Lotkowska, Adam J. Reid, Anneliese O. Speak, Paul Scott, Nicholas Redshaw, Charlotte Tolley, Catherine McCarthy, Cordelia Brandt, Catherine Sharpe, Caroline Ridley, Judit Gali Moya, Claudia M. Carneiro, Tobias Starborg, Kelly S. Hayes, Nancy Holroyd, Mandy Sanders, David J. Thornton, Richard K. Grencis, Matthew Berriman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Whipworms are large parasites causing chronic disease in humans and other mammals. Here, the authors show how larvae create tunnels inside the gut lining and reveal the early host response to infection via Isg15 in mice and murine caecaloids.
Externí odkaz:
https://doaj.org/article/86da51cf01e849638b4d23641665bd5e
Autor:
Kate A. Rawlinson, Adam J. Reid, Zhigang Lu, Patrick Driguez, Anna Wawer, Avril Coghlan, Geetha Sankaranarayanan, Sarah K. Buddenborg, Carmen Diaz Soria, Catherine McCarthy, Nancy Holroyd, Mandy Sanders, Karl F. Hoffmann, David Wilcockson, Gabriel Rinaldi, Matthew Berriman
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-21 (2021)
Abstract Background The consequences of the earth’s daily rotation have led to 24-h biological rhythms in most organisms. Even some parasites are known to have daily rhythms, which, when in synchrony with host rhythms, can optimise their fitness. U
Externí odkaz:
https://doaj.org/article/9c514beb10074835b2b16a2af319d0f5
Autor:
Duncan J. Berger, Thomas Crellen, Poppy H. L. Lamberton, Fiona Allan, Alan Tracey, Jennifer D. Noonan, Narcis B. Kabatereine, Edridah M. Tukahebwa, Moses Adriko, Nancy Holroyd, Joanne P. Webster, Matthew Berriman, James A. Cotton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Schistosomiasis control strategies rely on mass drug administration (MDA) using praziquantel. Here, Berger et al. perform whole-genome sequencing of larvae from infected children across Ugandan regions with differing MDA histories. They find extensiv
Externí odkaz:
https://doaj.org/article/c962db34a2b7473d882bdf56bb9ca5af
Autor:
Tushabe John Vianney, Duncan J Berger, Stephen R Doyle, Geetha Sankaranarayanan, Joel Serubanja, Prossy Kabuubi Nakawungu, Fred Besigye, Richard E Sanya, Nancy Holroyd, Fiona Allan, Emily L Webb, Alison M Elliott, Matthew Berriman, James A Cotton
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010188 (2022)
Populations within schistosomiasis control areas, especially those in Africa, are recommended to receive regular mass drug administration (MDA) with praziquantel (PZQ) as the main strategy for controlling the disease. The impact of PZQ treatment on s
Externí odkaz:
https://doaj.org/article/8d19e31e50b042949a5ec536490d0f46
Autor:
Peter D. Olson, Alan Tracey, Andrew Baillie, Katherine James, Stephen R. Doyle, Sarah K. Buddenborg, Faye H. Rodgers, Nancy Holroyd, Matt Berriman
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Chromosome-level assemblies are indispensable for accurate gene prediction, synteny assessment, and understanding higher-order genome architecture. Reference and draft genomes of key helminth species have been published, but littl
Externí odkaz:
https://doaj.org/article/fdb4e103b1744808941784716a4452bd
Autor:
Jeremy M. Foster, Alexandra Grote, John Mattick, Alan Tracey, Yu-Chih Tsai, Matthew Chung, James A. Cotton, Tyson A. Clark, Adam Geber, Nancy Holroyd, Jonas Korlach, Yichao Li, Silvia Libro, Sara Lustigman, Michelle L. Michalski, Michael Paulini, Matthew B. Rogers, Laura Teigen, Alan Twaddle, Lonnie Welch, Matthew Berriman, Julie C. Dunning Hotopp, Elodie Ghedin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Many nematode worms, including Caenorhabditis elegans have XX/XO sex determination, while other species have XY. The authors use a new genome assembly of the filarial parasite Brugia malayi and published data to show that nematode sex chromosome evol
Externí odkaz:
https://doaj.org/article/ea0bdea21b12449787ed0d4781e26b36
Autor:
Julien Kincaid-Smith, Alan Tracey, Ronaldo de Carvalho Augusto, Ingo Bulla, Nancy Holroyd, Anne Rognon, Olivier Rey, Cristian Chaparro, Ana Oleaga, Santiago Mas-Coma, Jean-François Allienne, Christoph Grunau, Matthew Berriman, Jérôme Boissier, Eve Toulza
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010062 (2021)
Schistosomes cause schistosomiasis, the world's second most important parasitic disease after malaria in terms of public health and social-economic impacts. A peculiar feature of these dioecious parasites is their ability to produce viable and fertil
Externí odkaz:
https://doaj.org/article/2cd797f3028e49928c34ef1b4d9b265b