Výsledky vyhledávání - "Nancy Gail Mayne"

Characterization of the neuropeptide Y5 receptor in the human hypothalamus: a lack of correlation between Y5 mRNA levels and binding sites

Autor: Lisa Selsam Beavers, J. Paul Burnett, Nancy Gail Mayne, Robert Alan Gadski, Susan L. Gackenheimer, Douglas A. Schober, Donald R. Gehlert, Michael A. Statnick, Dwayne Johnson

Publikováno v: Brain Research. 810:16-26

Neuropeptide Y (NPY) is a 36-amino-acid peptide that appears to play a central role in the control of feeding behavior. Recently, a cDNA encoding a novel NPY receptor subtype (Y5) was cloned from the rat and human hypothalamus, and shown to have a ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01223caf5eedd6d72269c86e4befca86
https://doi.org/10.1016/s0006-8993(98)00855-5

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LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

Autor: Rama M. Belagaje, Su Wu, Rebecca A. Wright, D D Schoepp, Bryan G. Johnson, Nancy Gail Mayne, J.P. Burnett, A.E. Kingston, Paul L. Ornstein

Publikováno v: Neuropharmacology. 37:1-12

The in vitro pharmacology of a structurally novel compound, LY341495, was investigated at human recombinant metabotropic glutamate (mGlu) receptor subtypes expressed in non-neuronal (RGT, rat glutamate transporter) cells. LY341495 was a nanomolar pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae70103fb8eec6096a1ee7bd77d6d18f
https://doi.org/10.1016/s0028-3908(97)00191-3

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LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors

Autor: James A. Monn, David Bleakman, J. Paul Burnett, Nancy Gail Mayne, Darryle D. Schoepp, Craig R. Salhoff, Bryan G. Johnson, S.L. Cockerham, Su Wu, Ramamoorthy Belegaje, Rebecca A. Wright

Publikováno v: Neuropharmacology. 36:1-11

The novel compound LY354740 is a conformationally constrained analog of glutamate, which was designed for interaction at metabotropic glutamate (mGlu) receptors. In this paper the selectivity of LY354740 for recombinant human mGlu receptor subtypes e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce26756481420e738a6760e53bee03d
https://doi.org/10.1016/s0028-3908(96)00160-8

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Analysis of NPY Receptor Subtypes in the Human Frontal Cortex Reveals Abundant Y1 mRNA and Binding Sites

Autor: Michael A. Statnick, J. Paul Burnett, Nancy Gail Mayne, Donald R. Gehlert, Douglas A. Schober

Publikováno v: Peptides. 18:137-143

Statnick, M. A., D. A. Schober, N. G. Mayne, J. P. Burnett and D. R. Gehlert. Analysis of NPY receptor subtypes in the human frontal cortex reveals abundant Y 1 mRNA and binding sites. Peptides 18(1) 137–143, 1997.—Receptors for neuropeptide Y (N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c9197ab51a58d4eb85bc393e961598
https://doi.org/10.1016/s0196-9781(96)00246-x

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The neuropeptide Y Y1 receptor selective radioligand, [125I][Leu31,Pro34]peptide YY, is also a high affinity radioligand for human pancreatic polypeptide 1 receptors

Autor: J. Paul Burnett, Lisa Selsam Beavers, Nancy Gail Mayne, Robert Alan Gadski, Ingrid Lundell, Douglas A. Schober, Susan L. Gackenheimer, Donald R. Gehlert, Dan Larhammar

Publikováno v: European Journal of Pharmacology. 318:485-490

A number of receptors for the pancreatic polypeptide-fold peptides are proposed based on findings from pharmacology and molecular biology studies. Neuropeptide Y and peptide YY have similar affinity for neuropeptide Y Y 1 and neuropeptide Y Y 2 while

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c860af4a413823ff8e2abd0927bc84b
https://doi.org/10.1016/s0014-2999(96)00797-2

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Pharmacological characterization of desensitization in a human mGlulα-expressing non-neuronal cell line co-transfected with a glutamate transporter

Autor: Nancy Gail Mayne, J.P. Burnett, D D Schoepp, M A Desai

Publikováno v: British Journal of Pharmacology. 118:1558-1564

1. Stimulation of phosphoinositide hydrolysis by human mGlu1 alpha (HmGlu1 alpha) was examined in a non-neuronal cell line (AV12-664) co-expressing both HmGlu1 alpha and a rat glutamate/aspartate transporter (GLAST). 2. Desensitization of HmGlu1 alph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5abee587d2ae280bc299ae9f5e3099e2
https://doi.org/10.1111/j.1476-5381.1996.tb15574.x

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Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate

Autor: James A. Monn, M A Desai, Craig R. Salhoff, Nancy Gail Mayne, Bryan G. Johnson, D D Schoepp, J.P. Burnett, M.J. Valu

Publikováno v: Neuropharmacology. 34:843-850

Metabotropic glutamate receptors (mGluRs) are a heterogeneous family of G-protein coupled receptors that are linked to multiple second messengers in the rat hippocampus. The compound 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec239b702ba153fe0210b0a43503d63b
https://doi.org/10.1016/0028-3908(95)00061-a

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Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines

Autor: A.E. Kingston, Barry Peter Clark, J. Lowndes, David Lodge, Nancy Gail Mayne, N. Evans, J.P. Burnett, S.L. Cockerham, Rosemarie Tomlinson

Publikováno v: Neuropharmacology. 37(3)

Comparison of the pharmacological effects of a range of sulphur-containing amino acids on human mGluR1alpha and mGluR5a has been undertaken. cDNAs of each mGluR were transfected into a Syrian hamster tumour cell line AV12-664 that was previously tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d0255ea8c728242399d1d5943d348f
https://pubmed.ncbi.nlm.nih.gov/9681926

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The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors

Autor: Craig R. Salhoff, J.P. Burnett, Bryan G. Johnson, Rebecca A. Wright, D D Schoepp, James A. Monn, Su Wu, Rama M. Belagaje, Nancy Gail Mayne

Publikováno v: Neuropharmacology. 35(12)

The mGlu receptor subtypes and second messenger pathways that mediate 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) responses in brain tissues are not fully understood. 1S,3R-ACPD differs from 3,5-dihydroxyphenylglycine (DHPG) or quisq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17755fa9d57f2b834de38f1fa4b29b4
https://pubmed.ncbi.nlm.nih.gov/9076745

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