Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nancy G. Pedigo"'
Publikováno v:
Physiological Genomics. 48:446-454
The FGD1 gene encodes for a guanine exchange factor (GEF) protein that specifically activates the Rho GTPase Cdc42. For cellular migration, Cdc42 is a key molecular switch that regulates cytoskeleton restructuring, gene transcription, cellular morpho
Recent cancer studies have suggested that the faciogenital dysplasia 1 (FGD1) gene may play a role in the development of tumor cells. Somatic alterations in the FGD1 gene and increased Fgd1 protein expression have been observed in many breast tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b1bb2f4e5ac2cb35e09331246eb94f
https://europepmc.org/articles/PMC4998584/
https://europepmc.org/articles/PMC4998584/
Publikováno v:
Experimental Lung Research. 34:155-182
The active form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, or calcitriol), is a potent mitogen for fibroblasts cultured from rat lungs at postnatal day 4 (P4), during the peak of septation (P3 to P7). In light of the key role of fibroblas
Publikováno v:
Gene Expression. 14:1-12
Retinoic acid (RA) upregulates expression of PDGF ligands and receptors in neonatal rat lung fibroblasts, a process likely to promote maturation of the lung alveolus and possibly microstructures of other organs. A mutational analysis of the gene enco
Publikováno v:
Gene. 348:25-32
Transcription of the PDGF-A chain gene is regulated by multiple promoter and silencer elements that are GC-rich and exhibit considerable single-stranded character. In this study, the 42 kDa single-stranded DNA and RNA binding protein, Puralpha, was i
Publikováno v:
Growth Factors. 21:151-160
Expression of the platelet-derived growth factor-A subunit (PDGF-A) is regulated to a significant degree by DNA elements located in the 5'-distal region of the gene. A potent basal enhancer (ACE66) located approximately 7 kb upstream of the transcrip
Autor:
Bin Liu, David M. Kaetzel, Nancy G. Pedigo, Stephen G. Zimmer, Zhenlan Xing, Zengliang Bai, Edith H. Postel, Deqin Ma
Publikováno v:
Journal of Biological Chemistry. 277:1560-1567
The platelet-derived growth factor (PDGF)-A promoter is regulated by a number of GC-rich regulatory elements that possess non-B-form DNA structures. Screening of a HeLa cDNA expression library with the C-rich strand of a PDGF-A silencer sequence (5'-
Objectives. To teach first-year (P1) pharmacy students to apply the principles of pharmacogenomics underlying clinical pharmacotherapeutics to cancer patients. Design. Using polymerase chain reaction (PCR) and high-resolution melting analysis of deox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8aaa6aa02b728e91fd72fd111efd398
https://europepmc.org/articles/PMC3996387/
https://europepmc.org/articles/PMC3996387/
Publikováno v:
Journal of Biological Chemistry. 273:33239-33246
Transient transfection analysis of DNA subfragments from the distal 5'-flanking region of the human platelet-derived growth factor A-chain gene (-18.3 to -1.8 kilobase pairs (kb)) revealed enhancer and silencer elements that contribute significantly
Publikováno v:
Journal of Neuro-Oncology. 39:33-46
Evidence is accumulating to suggest a role for PDGF in stimulating malignant growth in astrocytoma, although it has been obtained using model systems (growth in 2-dimensional cell culture, athymic nude mice) that do not assess the complex interaction