Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nancy G. J. Delaet"'
Autor:
Zhijun Wang, Erik Boman, Jan Urban, Jeff Kucharski, Hiroshi Nakanishi, Jan Lundström, Nancy G. J. Delaet, Justin T. Ernst, Eddine Saiah, Christopher Lum, Eric Erb, Antonio Garrido Montalban, Susana Conde Ceide, Russell Dahl, Linda Kessler, Stephen E. Miller, Christopher J. Larson, Chau-Dung Chang, Edward Roberts, Jeffrey Kahl, Robert K. P. Sullivan, Andrew Gibbs, David Dalesandro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4819-4824
We have optimized a novel series of potent p38 MAP kinase inhibitors based on an alpha-ketoamide scaffold through structure based design that due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In
Autor:
Jan Lundström, Eric Erb, Susana Conde Ceide, Eddine Saiah, Jeff Kahl, Stephen E. Miller, Andrew Gibbs, Edward Roberts, Nancy G. J. Delaet, Antonio Garrido Montalban, Robert K. P. Sullivan, Erik Boman, Zhijun Wang, Christopher J. Larson, David Dalesandro, Russell Dahl, Chau-Dung Chang, Hiroshi Nakanishi, Linda Kessler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5456-5459
We have identified a second series of potent p38 inhibitors. As with our first generation series, these compounds are based on an alpha-ketoamide scaffold. The reversal of the ketoamide order, however, introduces more chemical flexibility and in addi
Autor:
Eric Erb, Russell Dahl, Jan Lundström, Robert K. P. Sullivan, Chau-Dung Chang, Erik Boman, Edward Roberts, Antonio Garrido Montalban, Andrew Gibbs, Justin T. Ernst, Jeffrey Kahl, Hiroshi Nakanishi, Nancy G. J. Delaet, Eddine Saiah, Linda Kessler, Stephen E. Miller, Susana Conde Ceide, Christopher J. Larson, David Dalesandro, Zhijun Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1772-1777
We have identified a novel series of potent p38 MAP kinase inhibitors through structure-based design which due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In vitro ADME and in vivo PK studies s
Autor:
Harold E. Van Wart, Keith A. M. Walker, Leslie A. Robinson, Nancy G. J. Delaet, Robert L. Martin, Sharon M. Dankwardt, Christine S. Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2085-2088
A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP).
Publikováno v:
The Journal of Organic Chemistry. 58:1635-1638
Publikováno v:
ChemInform. 24
A comparative study of modern coupling reactions involving Boc-protected amino acid derivatives and dipeptides with N-terminal alpha,alpha-dialkylation and N-methylation was carried out. The coupling reactions were run using either equimolar amounts
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 33
Combinatorial libraries of substituted 3-thio-1,2,4-triazoles and 2-thioimidazoles were synthesized in good yield by alkylation of the products via the reaction of isothiocyanates and carboxylic acid hydrazides or beta-aminoketones, respectively. A t
Autor:
David Dalesandro, Eddine Saiah, Antonio Garrido Montalban, Justin T. Ernst, Stephen E. Miller, Christopher J. Larson, Hiroshi Nakanishi, Russell Dahl, Eric Erb, Edward Roberts, Zhijun Wang, Susana Conde Ceide, Linda Kessler, Jeffrey Kahl, Andrew Gibbs, Erik Boman, Robert K. P. Sullivan, Nancy G. J. Delaet, Chau-Dung Chang, Jan Lundström
Publikováno v:
European journal of pharmacology. 632(1-3)
The tumor necrosis factor-alpha (TNF-alpha) cytokine, secreted by activated monocytes/macrophages and T lymphocytes, is implicated in several diseases, including rheumatoid arthritis, chronic obstructive pulmonary disease, inflammatory bowel disease,
Autor:
H. E. Van Wart, Keith A. M. Walker, Sharon M. Dankwardt, Leslie A. Robinson, Robert L. Martin, Dean M. Wilson, R.W. Sullivan, Nancy G. J. Delaet, E.K. Bradley
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(13)
The parallel synthesis of novel inhibitors of procollagen C-terminal proteinase is described. The synthetic strategy allowed for the facile synthesis of a large number of side-chain diversified diamino acid hydroxamates, of which the d -diaminopropio