Zobrazeno 1 - 10 of 145 pro vyhledávání: '"Nancy Flournoy"'
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Akademický článek
Two-Stage Adaptive Optimal Design with Fixed First-Stage Sample Size
Autor: Adam Lane, Nancy Flournoy
Publikováno v: Journal of Probability and Statistics, Vol 2012 (2012)
In adaptive optimal procedures, the design at each stage is an estimate of the optimal design based on all previous data. Asymptotics for regular models with fixed number of stages are straightforward if one assumes the sample size of each stage goes
Externí odkaz: https://doaj.org/article/d2df0e2c10cd4870819bc4abc255b778
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2
Coping with Information Loss and the Use of Auxiliary Sources of Data: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions
Autor: Silvia Calderazzo, Sergey Tarima, Carissa Reid, Nancy Flournoy, Tim Friede, Nancy Geller, James L Rosenberger, Nigel Stallard, Moreno Ursino, Marc Vandemeulebroecke, Kelly Van Lancker, Sarah Zohar
Publikováno v: Statistics in Biopharmaceutical Research. :1-33
Clinical trials disruption has always represented a non negligible part of the ending of interventional studies. While the SARS-CoV-2 (COVID-19) pandemic has led to an impressive and unprecedented initiation of clinical research, it has also led to c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ba1a871f53d6dab4a43defabd92615
https://doi.org/10.1080/19466315.2023.2211023
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4
Most Powerful Test Sequences with Early Stopping Options
Autor: Nancy Flournoy, Sergey Tarima
Publikováno v: Metrika
Sequential likelihood ratio testing is found to be most powerful in sequential studies with early stopping rules when grouped data come from the one-parameter exponential family. First, to obtain this elusive result, the probability measure of a grou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07df3e65c69dabab1bbcbfa78aa73bc4
https://pubmed.ncbi.nlm.nih.gov/35602580
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8
Design considerations for two‐stage enrichment clinical trials
Autor: Rosamarie Frieri, William Fisher Rosenberger, Nancy Flournoy, Zhantao Lin
Publikováno v: Biometrics.
When there is a predictive biomarker, enrichment can focus the clinical trial on a benefiting subpopulation. We describe a two-stage enrichment design, in which the first stage is designed to efficiently estimate a threshold and the second stage is a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acefe1d41d8ae462c221208da79b2a45
https://doi.org/10.1111/biom.13805
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9
The effects of adaptation on maximum likelihood inference for nonlinear models with normal errors
Autor: Chiara Tommasi, Nancy Flournoy, Caterina May
Publikováno v: Journal of Statistical Planning and Inference. 214:139-150
This work studies the properties of the maximum likelihood estimator (MLE) of a multidimensional parameter in a nonlinear model with additive Gaussian errors. The observations are collected in a two-stage experimental design and are dependent because
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8f8045fbeea0eb9630fff40c71071bc
https://doi.org/10.1016/j.jspi.2021.02.002
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