Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nancy F. Tojais"'
Autor:
Lingli Wang, Jan-Renier Moonen, Aiqin Cao, Sarasa Isobe, Caiyun G. Li, Nancy F. Tojais, Shalina Taylor, David P. Marciano, Pin-I. Chen, Mingxia Gu, Dan Li, Rebecca L. Harper, Nesrine El-Bizri, Yu-Mee Kim, Kryn Stankunas, Marlene Rabinovitch
Publikováno v:
Circulation Research. 132:545-564
Objective: Mutations in BMPR2 (bone morphogenetic protein receptor 2) are associated with familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular link between loss of BMPR2 in pulmonary artery smooth muscle cells (PA
Autor:
Zhaoying Xian, Silin Sa, Caiyun G. Li, Christopher J. Rhodes, Michael Snyder, Jan K. Hennigs, Nancy F. Tojais, Rui Chen, Pin-I Chen, Roham T. Zamanian, Kazuya Miyagawa, Rachel K. Hopper, Nils Nickel, Aiqin Cao, Joseph C. Wu, Daniel Bernstein, Mark Kaschwich, Patricia A. del Rosario, Mingming Zhao, Lingli Wang, Edda Spiekerkoetter, Hogune Im, Marlene Rabinovitch, Mingxia Gu
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 192:356-366
Pulmonary arterial hypertension is characterized by endothelial dysregulation, but global changes in gene expression have not been related to perturbations in function.RNA sequencing was used to discriminate changes in transcriptomes of endothelial c
Autor:
Dan Li, Brian J. Feldman, Marlene Rabinovitch, Matthew Ye, Kazuya Miyagawa, Nancy F. Tojais, Lingli Wang, Jan K. Hennigs, Caiyun G. Li, Audrey S. Inglis, Pin-I Chen, Aiqin Cao, Nathaly M. Sweeney
Publikováno v:
JCI insight, vol 2, iss 2
Amphetamine (AMPH) or methamphetamine (METH) abuse can cause oxidative damage and is a risk factor for diseases including pulmonary arterial hypertension (PAH). Pulmonary artery endothelial cells (PAECs) from AMPH-associated-PAH patients show DNA dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495062e3e6b15ca43d260a9e86b9acb1
https://escholarship.org/uc/item/9g5942r4
https://escholarship.org/uc/item/9g5942r4
Autor:
Christopher J. Rhodes, Pin I. Chen, Nancy F. Tojais, Marlene Rabinovitch, Lynn Y. Sakai, Lingli Wang, Miguel A. Alejandre Alcazar, Aiqin Cao, Matthew Bill, Rachel K. Hopper, Ying Ju Lai, Vinicio A. de Jesus Perez
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 37(8)
Objective— We determined in patients with pulmonary arterial (PA) hypertension (PAH) whether in addition to increased production of elastase by PA smooth muscle cells previously reported, PA elastic fibers are susceptible to degradation because of
Autor:
Caiyun G. Li, Marlene Rabinovitch, Hirofumi Sawada, Lingli Wang, Vinicio A. de Jesus Perez, Nils Nickel, Mingming Zhao, Ke Yuan, Nancy F. Tojais, Roop Dutta, Viswanathan Rajagopalan, Mark Orcholski, Daniel Bernstein, Edda Spiekerkoetter
Publikováno v:
Circulation Research. 111:1551-1564
Rationale: Pulmonary hypertension (PH) is characterized by progressive elevation in pulmonary pressure and loss of small pulmonary arteries. As bone morphogenetic proteins promote pulmonary angiogenesis by recruiting the Wnt/β-catenin pathway, we pr
Autor:
Christopher J. Rhodes, Jan K. Hennigs, Marlene Rabinovitch, Mingxia Gu, Jan-Renier A. J. Moonen, Rachel K. Hopper, Isabel Diebold, Aiqin Cao, Nancy F. Tojais, Lingli Wang
Publikováno v:
Circulation, 133(18), 1783-1794. LIPPINCOTT WILLIAMS & WILKINS
Europe PubMed Central
Europe PubMed Central
Background— We previously reported high-throughput RNA sequencing analyses that identified heightened expression of the chromatin architectural factor High Mobility Group AT-hook 1 (HMGA1) in pulmonary arterial endothelial cells (PAECs) from patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553ef04b1a57f24b773f1510c800b790
http://hdl.handle.net/10044/1/31823
http://hdl.handle.net/10044/1/31823
Autor:
Frederic Larrieu-Lahargue, Pascale Dufourcq, Claire Peghaire, Thierry Couffinhal, Catherine Moreau, Annabelle Reynaud, Nathalie Franzl, Béatrice Jaspard, Cécile Duplàa, Nancy F. Tojais
Publikováno v:
Cardiovascular research. 103(2)
Aims Vascular permeability is essential for the health of normal tissues and is an important characteristic of many disease states. The role of the Wnt/frizzled pathway in vascular biology has recently been reported. The objectives of this study are