Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nancy F. Ramia"'
Autor:
Nancy F. Ramia, Michael Spilman, Li Tang, Yaming Shao, Joshua Elmore, Caryn Hale, Alexis Cocozaki, Nilakshee Bhattacharya, Rebecca M. Terns, Michael P. Terns, Hong Li, Scott M. Stagg
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1610-1617 (2014)
Summary: The Cmr complex is the multisubunit effector complex of the type III-B clustered regularly interspaced short palindromic repeats (CRISPR)-Cas immune system. The Cmr complex recognizes a target RNA through base pairing with the integral CRISP
Externí odkaz:
https://doaj.org/article/2c5352f1fab84d3189ed7347de470f5b
BackgroundBlack/African-American participants are underrepresented in clinical trials but can experience a greater burden of disease, such as multiple sclerosis, than other racial groups in the United States. A phase 1, open-label, 2-period crossover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2082b0b6e804a8630d6a0133a2d8e89a
https://doi.org/10.1101/2022.04.01.22272847
https://doi.org/10.1101/2022.04.01.22272847
Publikováno v:
Med. 3:612-621.e3
Black/African American participants are underrepresented in clinical trials for multiple sclerosis but can experience a greater burden of disease than other racial groups in the United States. A phase 1, open-label, crossover study that demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf10fa1ff134cb80d852ef618874177
https://doi.org/10.1016/j.medj.2022.06.006
https://doi.org/10.1016/j.medj.2022.06.006
Autor:
Maria Houtchens, Tatenda Mahlanza, Andrea I Ciplea, Maria Claudia Manieri, Nancy F Ramia, Yuan Zhao, Sarah England, Robin Avila, Arman Altincatal, Megan Vignos, Kerstin Hellwig
Publikováno v:
Multiple Sclerosis and Related Disorders. 60:103700
Peginterferon beta-1a is an interferon beta-1a formulation that has been pegylated, resulting in a longer half-life than other interferon beta formulations. We examined concentrations of peginterferon beta-1a in breast milk of lactating patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bf143031024848310cee144235f47a
https://doi.org/10.1016/j.msard.2022.103700
https://doi.org/10.1016/j.msard.2022.103700
Autor:
Nolan F. Sheppard, Nancy F. Ramia, Michael P. Terns, Trace Deighan, Hong Li, Joshua R. Elmore, Rebecca M. Terns
Publikováno v:
Genes & Development. 30:447-459
CRISPR–Cas systems eliminate nucleic acid invaders in bacteria and archaea. The effector complex of the Type III-B Cmr system cleaves invader RNAs recognized by the CRISPR RNA (crRNA ) of the complex. Here we show that invader RNAs also activate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4f60ad8d045bb5346610d98224883e
https://doi.org/10.1101/gad.272153.115
https://doi.org/10.1101/gad.272153.115
Autor:
Linda N. Casillas, Viera Kasparcova, Bryan W. King, Peter J. Gough, Francis Ka-Ming Chan, Edward S. Mocarski, Bart Votta, Pamela A. Haile, Linda Roback, John D. Lich, Ami S. Lakdawala, Clark A. Sehon, Joshua N. Finger, Cole M. Dovey, Chunzi Huang, David D. Wisnoski, Jan E. Carette, Pratyusha Mandal, Sirika Pillay, Michael T. Ouellette, Scott B. Berger, Nancy F. Ramia, John Bertin, Demartino Michael P, Kenta Moriwaki, Robert W. Marquis, Hongyan Guo, Jason W. Upton, William J. Kaiser, Lisa P. Daley-Bauer
Publikováno v:
Molecular Cell. 56(4):481-495
Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease. Here, three selective small-molecule compounds are shown to inhibit RIP3 kinase-dependent nec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de448ef751b2b6c6636b73dc01edec7
Autor:
Caryn Hale, Nancy F. Ramia, Yaming Shao, Michael P. Terns, Rebeca Terns, Hong Li, Michael S. Spilman, Alexis I. Cocozaki, Scott M. Stagg
Publikováno v:
Molecular Cell. 52:146-152
Summary Bacterial and archaeal clustered regularly interspaced short palindromic repeat (CRISPR) loci capture virus and plasmid sequences and use them to recognize and eliminate these invaders. CRISPR RNAs (crRNAs) containing the acquired sequences a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368fdea245566cde656ee655886da2e4
https://doi.org/10.1016/j.molcel.2013.09.008
https://doi.org/10.1016/j.molcel.2013.09.008
Autor:
Caryn Hale, Michael P. Terns, Nancy F. Ramia, Hong Li, Yaming Shao, Alexis I. Cocozaki, Rebecca M. Terns
Publikováno v:
Structure. 20(3):545-553
SummaryCmr2 is the largest and an essential subunit of a CRISPR RNA-Cas protein complex (the Cmr complex) that cleaves foreign RNA to protect prokaryotes from invading genetic elements. Cmr2 is thought to be the catalytic subunit of the effector comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c310e907b743d755134b88495329a0e
Autor:
Nancy F. Ramia, Jing Huang, Neal S. Silverman, Yanfang Shen, Johanna Napetschnig, Jixi Li, Hao Wu, Gunes Bozkurt, Monique Gangloff, Himani Nailwal, Francis Ka-Ming Chan, Anni Kleino
Publikováno v:
Immunity. 47:635-647.e6
Summary In the Drosophila immune response, bacterial derived diaminopimelic acid-type peptidoglycan binds the receptors PGRP-LC and PGRP-LE, which through interaction with the adaptor protein Imd leads to activation of the NF-κB homolog Relish and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb219be8e1513d36b92420bb8116ad4
https://doi.org/10.1016/j.immuni.2017.09.011
https://doi.org/10.1016/j.immuni.2017.09.011
Publikováno v:
Structure (London, England : 1993). 21(3)
SummaryThe Cmr complex is an RNA-guided effector complex that cleaves invader RNA in the prokaryotic immune response mediated by the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)-Cas system. Here, we report the crystal structure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce002f773ac248433efd02f739996c0e
https://pubmed.ncbi.nlm.nih.gov/23395183
https://pubmed.ncbi.nlm.nih.gov/23395183