Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Nancy E. Everds"'
Autor:
Nancy E. Everds, Gerald L. Kennedy
Publikováno v:
Toxicology Reports, Vol 2, Iss C, Pp 70-77 (2015)
In epidemiology studies, the presence of perfluorooctanoate (PFOA) in human blood has been associated with higher serum cholesterol concentrations. A possible explanation for these results is that elevated serum cholesterol might reduce clearance of
Externí odkaz:
https://doaj.org/article/a1896a219e734e76afc2cfdb945a9dc8
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine
Purpose: Doxorubicin-related heart failure has been recognized as a serious complication of cancer chemotherapy. This paper describes a cardiovascular safety pharmacology study with chronic dosing of doxorubicin in a non-human primate model designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3eef762f8e7286ae301274e3fe1eaf9
https://doi.org/10.3389/fcvm.2021.587149
https://doi.org/10.3389/fcvm.2021.587149
Autor:
Madeline M. Fort, Nancy E. Everds, Mai Phuong Nguyen, Linda O. Narhi, Darcey Clark, Yan Bin Yu, Padma K. Narayanan, Nianyu Li, Yao Zhuang, Riki Stevenson, Kannan Gunasekaran, Jeanine L. Bussiere, Ling Liu, Kei Kim, Frederick W. Jacobsen
Publikováno v:
Journal of Biological Chemistry. 292:1876-1883
The stable effector functionLess (SEFL) antibody was designed as an IgG1 antibody with a constant region that lacks the ability to interact with Fcγ receptors. The engineering and stability and pharmacokinetic assessments of the SEFL scaffold is des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a204efe86df5cc245649bcfd88de2ae9
https://doi.org/10.1074/jbc.m116.748707
https://doi.org/10.1074/jbc.m116.748707
Autor:
Nancy E. Everds
Publikováno v:
Toxicologic Pathology. 45:275-280
Preanalytical variables can have significant impacts on clinical pathology parameters evaluated during the conduct of a nonclinical safety or toxicity study. These preanalytical variables can be controlled by careful attention to factors such as anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86502b577fe385feb3f64bbc1970ae23
https://doi.org/10.1177/0192623316680783
https://doi.org/10.1177/0192623316680783
Publikováno v:
Toxicologic pathology. 47(1)
We assessed the variability of spleen and mesenteric lymph node (MLN) microscopic observations and the correlations of these observations with other study data from 478 control cynomolgus monkeys from 53 routine nonclinical safety studies. Spleen wei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d163979add7f9160d21f833210064d92
https://pubmed.ncbi.nlm.nih.gov/30563426
https://pubmed.ncbi.nlm.nih.gov/30563426
Autor:
Paul Brown, Megan Bausman, Nancy E. Everds, Judith W. Henck, Lauren Murphree Mihalcik, John Sims, Dan Potenta, Jennifer Feldmann, Joyce Zandee
Publikováno v:
Therapeutic innovationregulatory science. 50(2)
Access and use of historical control data was identified as a top stakeholder concern across organizations according to results of a survey of needs and challenges related to nonclinical data conducted by the FDA/PhUSE Nonclinical Working Group in 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb2dad986d5993e90f50346604149d4
https://pubmed.ncbi.nlm.nih.gov/30227010
https://pubmed.ncbi.nlm.nih.gov/30227010
Autor:
L. Mihalcik, Vibha Jawa, M. Lepherd, Nancy E. Everds, Jeanine L. Bussiere, M.P. Sirivelu, Alok K. Sharma, D.T. Mytych
Undesired consequences of immune responses to therapeutic molecules can be difficult to predict. Small molecules are usually not directly immunogenic but may cause immune-mediated hypersensitivity reactions following processing or interactions with e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0479be75fa16d062d49bc906e1eaaf6
https://doi.org/10.1016/b978-0-12-801238-3.64257-5
https://doi.org/10.1016/b978-0-12-801238-3.64257-5
Autor:
Gerald L. Kennedy, Nancy E. Everds
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 2, Iss C, Pp 70-77 (2015)
Toxicology Reports, Vol 2, Iss C, Pp 70-77 (2015)
In epidemiology studies, the presence of perfluorooctanoate (PFOA) in human blood has been associated with higher serum cholesterol concentrations. A possible explanation for these results is that elevated serum cholesterol might reduce clearance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5af9d4571f19249089250c07f2a5859
http://europepmc.org/articles/PMC5598093
http://europepmc.org/articles/PMC5598093
Autor:
Nancy E. Everds, Lila Ramaiah
Publikováno v:
The Clinical Chemistry of Laboratory Animals ISBN: 9781315155807
The laboratory rat is one of the most extensively used animal models in biomedical research. The modern laboratory rat is considered to be derived from naturally occurring albino mutants of the wild Norway rat (Rattus norvegicus), which originated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81de73350c5f29fd3cef59b8e570615
https://doi.org/10.1201/9781315155807-2
https://doi.org/10.1201/9781315155807-2
Autor:
Nancy E, Everds
Publikováno v:
Toxicologic pathology. 45(2)
Preanalytical variables can have significant impacts on clinical pathology parameters evaluated during the conduct of a nonclinical safety or toxicity study. These preanalytical variables can be controlled by careful attention to factors such as anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bad3da88e9eaf616a5a067548d418c5
https://pubmed.ncbi.nlm.nih.gov/28178898
https://pubmed.ncbi.nlm.nih.gov/28178898