Zobrazeno 1 - 10
of 591
pro vyhledávání: '"Nancy E, Lane"'
Autor:
Kwanghoon Lee, Marina Banuls-Mirete, Alecio F. Lombardi, Alexander I.B. Posis, Eric Y. Chang, Nancy E. Lane, Monica Guma
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-9 (2024)
Abstract Objectives Adipose tissue has been associated with knee osteoarthritis (KOA) pathogenesis, but the longitudinal changes in adipose tissue with KOA progression have not been carefully evaluated. This study aimed to determine if longitudinal c
Externí odkaz:
https://doaj.org/article/ef9f80152e8140819338a8102365dfad
Autor:
Felix G. Gassert, Gabby B. Joseph, John A. Lynch, Johanna Luitjens, Michael C. Nevitt, Charles E. McCulloch, Nancy E. Lane, Sharmila Majumdar, Thomas M. Link
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Objective While risk factors for osteoarthritis (OA) are well known, it is not well understood why certain individuals maintain high mobility and joint health throughout their life while others demonstrate OA at older ages. The purpose of th
Externí odkaz:
https://doaj.org/article/f6cd7746b55a45a9899d096e49055ef4
Autor:
Anjum Shaik, Kristoffer Larsen, Nancy E. Lane, Chen Zhao, Kuan-Jui Su, Joyce H. Keyak, Qing Tian, Qiuying Sha, Hui Shen, Hong-Wen Deng, Weihua Zhou
Publikováno v:
Bone Reports, Vol 22, Iss , Pp 101805- (2024)
Hip fractures present a significant healthcare challenge, especially within aging populations, where they are often caused by falls. These fractures lead to substantial morbidity and mortality, emphasizing the need for timely surgical intervention. D
Externí odkaz:
https://doaj.org/article/72ff07d14f2343cf963820df19849a0d
Autor:
Maximilian T. Löffler, Chotigar Ngarmsrikam, Paula Giesler, Gabby B. Joseph, Zehra Akkaya, John A. Lynch, Nancy E. Lane, Michael Nevitt, Charles E. McCulloch, Thomas M. Link
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Obesity influences the development of osteoarthritis via low-grade inflammation. Progression of local inflammation (= synovitis) increased with weight gain in overweight and obese women compared to stable weight. Synovitis could b
Externí odkaz:
https://doaj.org/article/128d7f85bef643e2babcec9a4adfb6b9
Autor:
Christina Charles-Schoeman, Jon T. Giles, Nancy E. Lane, Ernest Choy, Daniel E. Furst, Jiří Vencovský, Anthony G. Wilson, Gerd R. Burmester, Derek Coombs, Sara K. Penn, Nasser Khan, Jillian B. Yee, Kassim Rahawi, Iain B. McInnes
Publikováno v:
Rheumatology and Therapy, Vol 11, Iss 1, Pp 157-175 (2024)
Abstract Introduction Upadacitinib (UPA) is a Janus kinase inhibitor that has demonstrated efficacy in moderate-to-severe rheumatoid arthritis (RA) with an acceptable safety profile. We investigated laboratory parameter changes in UPA RA clinical tri
Externí odkaz:
https://doaj.org/article/7848bcb7d51248bd8d20a0519b6de718
Autor:
Nancy E. Lane, Donald Betah, Cynthia Deignan, Mary Oates, Zhenxun Wang, Jen Timoshanko, Aliya A. Khan, Neil Binkley
Publikováno v:
ACR Open Rheumatology, Vol 6, Iss 1, Pp 43-51 (2024)
Objective Romosozumab is a bone‐forming agent approved for osteoporosis treatment. Here we report results of the protocol‐specified, noninferiority osteoarthritis substudy of the fracture study in postmenopausal women with osteoporosis (FRAME), w
Externí odkaz:
https://doaj.org/article/5f62b41b22b6442eac683f398d10d2d2
Autor:
Sita M A Bierma-Zeinstra, Stefan Kluzek, David Felson, Graeme Jones, Rintje Agricola, Nigel K Arden, Joshua Heerey, Andrea B Mosler, Flavia Cicuttini, Jos Runhaar, M Nevitt, Nancy E Lane, John A Lynch, Harrie Weinans, Timothy F Cootes, Kay Crossley, Cindy G Boer, Willem Paul Gielis, Edwin Oei, Michiel M A van Buuren, Noortje S Riedstra, Myrthe A van den Berg, Fleur D E M Boel, Harbeer Ahedi, Vahid Arbabi, Claudia Lindner, J Van Meurs, Amanda E Nelson, Jinchi Tang
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Purpose Hip osteoarthritis (OA) is a major cause of pain and disability worldwide. Lack of effective therapies may reflect poor knowledge on its aetiology and risk factors, and result in the management of end-stage hip OA with costly joint replacemen
Externí odkaz:
https://doaj.org/article/2950d568396a49abbc5b2d988c32ccbe
Autor:
Karen Y. Cheng, Elsa S. Strotmeyer, Deborah M. Kado, John T. Schousboe, Simon Schenk, Michael Nevitt, Nancy E. Lane, Jan M. Hughes‐Austin
Publikováno v:
ACR Open Rheumatology, Vol 5, Iss 3, Pp 115-123 (2023)
Objective Metabolic dysregulation frequently co‐occurs with obesity, which has been shown to be a risk factor for lower extremity osteoarthritis (OA). We evaluated the association between metabolic syndrome (MetS), alone and in combination with obe
Externí odkaz:
https://doaj.org/article/051b4d8365f24119bcb65fb8c5ca38f3
Autor:
Benjamin G. Faber, Monika Frysz, Cindy G. Boer, Daniel S. Evans, Raja Ebsim, Kaitlyn A. Flynn, Mischa Lundberg, Lorraine Southam, April Hartley, Fiona R. Saunders, Claudia Lindner, Jennifer S. Gregory, Richard M. Aspden, Nancy E. Lane, Nicholas C. Harvey, David M. Evans, Eleftheria Zeggini, George Davey Smith, Timothy Cootes, Joyce Van Meurs, John P. Kemp, Jonathan H. Tobias
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104759- (2023)
Summary: Background: Hip minimum joint space width (mJSW) provides a proxy for cartilage thickness. This study aimed to conduct a genome-wide association study (GWAS) of mJSW to (i) identify new genetic determinants of mJSW and (ii) identify which mJ
Externí odkaz:
https://doaj.org/article/e65b32b807094d3195f523dc966a7bd4
Autor:
Leo D. Westbury, Charlotte Beaudart, Olivier Bruyère, Jane A. Cauley, Peggy Cawthon, Alfonso J. Cruz‐Jentoft, Elizabeth M. Curtis, Kristine Ensrud, Roger A. Fielding, Helena Johansson, John A. Kanis, Magnus K. Karlsson, Nancy E. Lane, Laetitia Lengelé, Mattias Lorentzon, Eugene McCloskey, Dan Mellström, Anne B. Newman, Claes Ohlsson, Eric Orwoll, Jean‐Yves Reginster, Eva Ribom, Björn E. Rosengren, John T. Schousboe, Eric J. Shiroma, Nicholas C. Harvey, Elaine M. Dennison, Cyrus Cooper, the International Musculoskeletal Ageing Network
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 565-575 (2023)
Abstract Background The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these
Externí odkaz:
https://doaj.org/article/6cf7d4d2fefb4b71800895ecc46edd4a