Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Nancy Dos, Santos"'
Autor:
Abdulaziz Alhussan, Nolan Jackson, Norman Chow, Ermias Gete, Nicole Wretham, Nancy Dos Santos, Wayne Beckham, Cheryl Duzenli, Devika B. Chithrani
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 713 (2024)
This research underscores the potential of combining nanotechnology with conventional therapies in cancer treatment, particularly for challenging cases like pancreatic cancer. We aimed to enhance pancreatic cancer treatment by investigating the syner
Externí odkaz:
https://doaj.org/article/da12d4fe204b42e1b9d76ee5d42418a7
Autor:
Kyle Bromma, Nancy Dos Santos, Ingrid Barta, Abraham Alexander, Wayne Beckham, Sunil Krishnan, Devika B. Chithrani
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Recent clinical trials show docetaxel (DTX), given in conjunction with radiation therapy (RT) and androgen suppression, improves survival in high-risk prostate cancer. Addition of gold nanoparticles (GNPs) to this current DTX/RT protocol is
Externí odkaz:
https://doaj.org/article/e49fc97f980f416e966cd2ae708ed4c6
Autor:
Chandra Lebovitz, Nicole Wretham, Maryam Osooly, Katy Milne, Tia Dash, Shelby Thornton, Basile Tessier-Cloutier, Paalini Sathiyaseelan, Svetlana Bortnik, Nancy Erro Go, Elizabeth Halvorsen, Rachel A. Cederberg, Norman Chow, Nancy Dos Santos, Kevin L. Bennewith, Brad H. Nelson, Marcel B. Bally, Wan L. Lam, Sharon M. Gorski
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson’s disease, whereas our previous analyses of public cancer patient data revealed that decreased LRRK2 expression is as
Externí odkaz:
https://doaj.org/article/a628231eefc547ca89a67c8ce3fcdf31
Autor:
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J. O’Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia, Farhia Kabeer, Daniel Lai, Priscilla Soriano, Judit Banáth, Derek S. Chiu, Damian Yap, Daniel D. Le, Frank B. Ye, Anni Zhang, Kelsie Thu, John Soong, Shu-chuan Lin, Angela Hsin Chin Tsai, Tomo Osako, Teresa Algara, Darren N. Saunders, Jason Wong, Jian Xian, Marcel B. Bally, James D. Brenton, Grant W. Brown, Sohrab P. Shah, David Cescon, Tak W. Mak, Carlos Caldas, Peter C. Stirling, Phil Hieter, Shankar Balasubramanian, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Stabilization of DNA quadruplex structures (G4) is lethal for cells with a compromised DNA repair pathway. Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be
Externí odkaz:
https://doaj.org/article/5b722e62084b4032919682ab16257e1a
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Table S1 shows the cell viability inhibitory rate (%) in SCCOHT cell lines vs other cell lines in the epigenetic drug screen. Table S2 shows the effects of Quisinostat on the proteome of BIN67 cells after treatment for 24 or 72 hours. Table S3 shows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43304537c45779fc06e18054f0e3bb95
https://doi.org/10.1158/1535-7163.22510060.v1
https://doi.org/10.1158/1535-7163.22510060.v1
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Fig.S1 shows that SCCOHT cells are sensitive to HDAC inhibition. Fig. S2 shows that SCCOHT cells are sensitive to HDAC inhibition or depletion. Fig.S3 shows that SMARCA4/A2 dual deficiency is not associated with hypersensitivity to HDAC inhibitors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2396ee9de14b76e5d7859ed9f267bb73
https://doi.org/10.1158/1535-7163.22510063.v1
https://doi.org/10.1158/1535-7163.22510063.v1
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but extremely lethal malignancy that mainly impacts young women. SCCOHT is characterized by a diploid genome with loss of SMARCA4 and lack of SMARCA2 expression, two mutually ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37952b52d6236e3e9efd5a279b26f72e
https://doi.org/10.1158/1535-7163.c.6539491
https://doi.org/10.1158/1535-7163.c.6539491
Autor:
Lawrence D. Mayer, David G. Bermudes, Alan W. Tsang, Natalia Zisman, Sharon A. Johnstone, Troy O. Harasym, Nancy Dos Santos, Paul G. Tardi
Supplementary Data from Drug ratio–dependent antitumor activity of irinotecan and cisplatin combinations in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07934a3521d14aa54df7d7bedd861346
https://doi.org/10.1158/1535-7163.22485519.v1
https://doi.org/10.1158/1535-7163.22485519.v1
Autor:
Lawrence D. Mayer, David G. Bermudes, Alan W. Tsang, Natalia Zisman, Sharon A. Johnstone, Troy O. Harasym, Nancy Dos Santos, Paul G. Tardi
Irinotecan and cisplatin are two established anticancer drugs, which together constitute an effective combination for treating small-cell lung cancer. We investigated whether the efficacy of this combination could be improved by controlling drug rati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1f2b7b051e3bcf8e947f63264e3d55
https://doi.org/10.1158/1535-7163.c.6531972
https://doi.org/10.1158/1535-7163.c.6531972
Autor:
null Ana Rita Albuquerque Zito, null Nancy dos Santos Pinto Ferreira, null Marisha Oliveira dos Santos, null Beatriz Alves Furtado, null Leticia Helena Theodoro
Publikováno v:
RSBO. 18:348-57
Pessoas acometidas por paralisia cerebral podem apresentar limitações de funcionalidade que influenciam na realização de suas atividades de vida diária. No que se refere à saúde bucal das pessoas com deficiência, encontraram-se dados indicand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59b04de72cc26823a2ce595924883bcc
https://doi.org/10.21726/rsbo.v18i2.1614
https://doi.org/10.21726/rsbo.v18i2.1614