Výsledky vyhledávání - "Nancy Detich"

Valproate Induces Replication-independent Active DNA Demethylation

Autor: Veronica Bovenzi, Moshe Szyf, Nancy Detich

Publikováno v: Journal of Biological Chemistry. 278:27586-27592

In this report, we demonstrate that valproic acid (VPA), a drug that has been used for decades in the treatment of epilepsy and as a mood stabilizer, triggers replication-independent active demethylation of DNA. Thus, this drug can potentially revers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e289537ea46b14ac9e3ad0d3774f6231
https://doi.org/10.1074/jbc.m303740200

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The Methyl Donor S-Adenosylmethionine Inhibits Active Demethylation of DNA

Autor: Moshe Szyf, J. David Knox, Nancy Detich, George Just, Stefan Hamm

Publikováno v: Journal of Biological Chemistry. 278:20812-20820

S-Adenosylmethionine (AdoMet) is the methyl donor of numerous methylation reactions. The current model is that an increased concentration of AdoMet stimulates DNA methyltransferase reactions, triggering hypermethylation and protecting the genome agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3fc146a726a5ef6c0de2bf9cd3ed70d
https://doi.org/10.1074/jbc.m211813200

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The Oncoprotein Set/TAF-1β, an Inhibitor of Histone Acetyltransferase, Inhibits Active Demethylation of DNA, Integrating DNA Methylation and Transcriptional Silencing

Autor: Debabrata Chakravarti, Sang Beom Seo, Moshe Szyf, Nadia Cervoni, Nancy Detich

Publikováno v: Journal of Biological Chemistry. 277:25026-25031

Histone hypoacetylation and DNA hypermethylation are hallmarks of gene silencing. Although a role for DNA methylation in regulating histone acetylation has been established, it is not clear how and whether epigenetic histone markings influence DNA mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa44283ceac780c7657ca82599a59ed
https://doi.org/10.1074/jbc.m202256200

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Bis( N,N -dimethylhydroxamido)hydroxooxovanadate inhibition of protein tyrosine phosphatase activity in intact cells

Autor: Nancy Detich, Michael J. Gresser, Cary Cuncic, Sylvie Desmarais, Chidambaram Ramachandran, Alan S. Tracey

Publikováno v: Biochemical Pharmacology. 58:1859-1867

We have shown previously that bis(N,N-dimethylhydroxamido)hydroxooxovanadate (DMHV) is an excellent reversible inhibitor of protein tyrosine phosphatase (PTP) in vitro. DMHV does not carry a charge under physiological pH conditions and is anticipated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b9c4cd2ebdb9b4bdd6a4608a4af18f0
https://doi.org/10.1016/s0006-2952(99)00284-1

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The Role of Active Demethylation in Cancer and Its Therapeutic Potential

Autor: Veronica Bovenzi, Stefan Hamm, Moshe Szyf, Jing Ni Ou, Paul M. Campbell, Nancy Detich

Publikováno v: DNA Methylation and Cancer Therapy ISBN: 9780306478482

Regional hypermethylation and global hypomethylation coexist in cancer cells. Under-standing the mechanisms responsible for global hypomethylation and regional hypermethylation in cancer is required for the proper design of therapeutic strategies tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81297096e3400292c617be580d57e063
https://doi.org/10.1007/0-387-27443-x_12

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The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine

Autor: Nancy, Detich, Stefan, Hamm, George, Just, J David, Knox, Moshe, Szyf

Publikováno v: The Journal of biological chemistry. 278(23)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e9aedc3797ef594cf8cd98f7f1b68b8
https://pubmed.ncbi.nlm.nih.gov/12676953

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A conserved 3'-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity

Autor: Shyam Ramchandani, Nancy Detich, Moshe Szyf

Publikováno v: The Journal of biological chemistry. 276(27)

Ectopic expression of DNA methyltransferase 1 (DNMT1) has been proposed to play an important role in cancer.dnmt1 mRNA is undetectable in growth-arrested cells but is induced upon entrance into the S phase of the cell cycle, and until now, the mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3dc68875043b746d7c4dcfffad78ec6
https://pubmed.ncbi.nlm.nih.gov/11335728

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Regulation of the DNA methylation machinery and its role in cellular transformation

Autor: Moshe Szyf, Nancy Detich

Publikováno v: Progress in Nucleic Acid Research and Molecular Biology ISBN: 9780125400695

DNA methylation, a covalent modification of the genome, is emerging as an important player in the regulation of gene expression. This review discusses the different components of the DNA methylation machinery responsible for replicating the DNA methy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a60a85828a2d89ca2f9cbe40cd2d016
https://doi.org/10.1016/s0079-6603(01)69044-5

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Vanadate inhibition of protein tyrosine phosphatases in Jurkat cells: modulation by redox state

Autor: Michael J. Gresser, Nancy Detich, Cary Cuncic, Diane Ethier, Alan S. Tracey, Chidambaran Ramachandran

Publikováno v: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 4(3)

Vanadate is a potent reversible inhibitor of protein tyrosine phosphatases (PTP) in vitro. Vanadate has been shown to increase the phosphotyrosine levels in some cell types whereas in others, like the Jurkat T-lymphoma, vanadate has no effect. The re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e408782a343d3aff1d81397fc9dba369
https://pubmed.ncbi.nlm.nih.gov/10439081

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