Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nancy D. Pomarici"'
Autor:
Monica L. Fernández-Quintero, Nancy D. Pomarici, Anna-Lena M. Fischer, Valentin J. Hoerschinger, Katharina B. Kroell, Jakob R. Riccabona, Anna S. Kamenik, Johannes R. Loeffler, James A. Ferguson, Hailee R. Perrett, Klaus R. Liedl, Julianna Han, Andrew B. Ward
Publikováno v:
Antibodies, Vol 12, Iss 4, p 67 (2023)
Antibodies and other new antibody-like formats have emerged as one of the most rapidly growing classes of biotherapeutic proteins. Understanding the structural features that drive antibody function and, consequently, their molecular recognition is cr
Externí odkaz:
https://doaj.org/article/ebfea549dcaf49caafa4ea894542b32c
Autor:
Nancy D. Pomarici, Roberta Cacciato, Janik Kokot, Monica L. Fernández-Quintero, Klaus R. Liedl
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 801 (2023)
The adaptive immune system arose around 500 million years ago in jawed fish, and, since then, it has mediated the immune defense against pathogens in all vertebrates. Antibodies play a central role in the immune reaction, recognizing and attacking ex
Externí odkaz:
https://doaj.org/article/2231e26d39cf4c8aaa97a1d8c9ba401a
Autor:
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/863a1215e8194a08a42b208a8195a801
Autor:
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy. When designing new formats, a target
Externí odkaz:
https://doaj.org/article/54e0f0f4d5ce4f6eb11bbfda2d108352
Autor:
Nancy D. Pomarici, Franz Waibl, Patrick K. Quoika, Alexander Bujotzek, Guy Georges, Monica L. Fernández-Quintero, Klaus R. Liedl
Publikováno v:
Journal of Computer-Aided Molecular Design. 37:201-215
Therapeutic antibodies should not only recognize antigens specifically, but also need to be free from developability issues, such as poor stability. Thus, the mechanistic understanding and characterization of stability are critical determinants for r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7515b4a4140460e9cc98b56a7bde044
https://doi.org/10.1007/s10822-023-00501-9
https://doi.org/10.1007/s10822-023-00501-9
Autor:
Monica L. Fernández-Quintero, Nancy D. Pomarici, Johannes R. Loeffler, Clarissa A. Seidler, Klaus R. Liedl
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
T-cell receptors are an important part in the adaptive immune system as they are responsible for detecting foreign proteins presented by the major histocompatibility complex (MHC). The affinity is predominantly determined by structure and sequence of
Externí odkaz:
https://doaj.org/article/512582b50af24d909b1a7ae0e476671c
Autor:
Monica L. Fernández-Quintero, Martin C. Heiss, Nancy D. Pomarici, Barbara A. Math, Klaus R. Liedl
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
In the past decade, the relevance of antibodies as therapeutics has increased substantially. Therefore, structural and functional characterization, in particular of the complementarity-determining regions (CDRs), is crucial to the design and engineer
Externí odkaz:
https://doaj.org/article/1a79298688a04a2b88d16168dab16c49
Autor:
Nancy D Pomarici, Monica L Fernández-Quintero, Patrick K Quoika, Franz Waibl, Alexander Bujotzek, Guy Georges, Klaus R Liedl
Publikováno v:
Protein engineering, designselection : PEDS. 35
A new format of therapeutic proteins is bispecific antibodies, in which two different heavy chains heterodimerize to obtain two different binding sites. Therefore, it is crucial to understand and optimize the third constant domain (CH3-CH3) interface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9442c015c7c785c78082b2e227deaaa
https://pubmed.ncbi.nlm.nih.gov/36468666
https://pubmed.ncbi.nlm.nih.gov/36468666
Autor:
Katharina B. Kroell, Nancy D. Pomarici, Monica L. Fernández-Quintero, Franz Waibl, Guy Georges, Alexander Bujotzek, Klaus R. Liedl, Barbara A. Math
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six hypervariable loops, also known as complementarity det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15385045a161d11f60c3730d2389ceae
http://link.springer.com/article/10.1038/s42003-020-01319-z
http://link.springer.com/article/10.1038/s42003-020-01319-z
Autor:
Monica L, Fernández-Quintero, Nancy D, Pomarici, Barbara A, Math, Katharina B, Kroell, Franz, Waibl, Alexander, Bujotzek, Guy, Georges, Klaus R, Liedl
Publikováno v:
Communications Biology
In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six hypervariable loops, also known as complementarity det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acf4ff388f59c0aa348dd99272f412be
https://pubmed.ncbi.nlm.nih.gov/33082531
https://pubmed.ncbi.nlm.nih.gov/33082531