Výsledky vyhledávání - "Nancy D. Elkins"

Inhalation of two putative Gulf War toxins by mice

Autor: Uwe Christians, Paul Wilson, John E. Repine, Ben Peters, Nancy D. Elkins, Jelena Klawitter, Dwight M. Smith

Publikováno v: Journal of Environmental Science and Health, Part B. 51:366-373

We employed our inhalation methodology to examine whether biomarkers of inflammation and oxidative stress would be produced in mice following inhalation of aerosols containing carbonaceous particles or the vapor of pesticides prevalent during the fir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4e6be2b19dd659af54f7429f37f87d
https://doi.org/10.1080/03601234.2016.1142318

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Early Increase in Alveolar Macrophage Prostaglandin 15d-PGJ2 Precedes Neutrophil Recruitment into Lungs of Cytokine-Insufflated Rats

Autor: Amanda Agazio, Koji Uchida, Ana Fernandez-Bustamante, Uwe Christians, Takahiro Shibata, Jelena Klawitter, Nancy D. Elkins, John E. Repine, Paul F. Wilson

Publikováno v: Inflammation. 36:1030-1040

Early detection and prevention is an important goal in acute respiratory distress syndrome research. We determined the concentration of the anti-inflammatory 15-deoxy-Δ(12,14)-prostaglandin-J2 (15d-PGJ2) and other components of the cyclopentenone pr

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https://doi.org/10.1007/s10753-013-9635-x

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Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonanceT1relaxation

Autor: Karl F. Stupic, Galina E. Pavlovskaya, Thomas Meersmann, Nancy D. Elkins, John E. Repine

Publikováno v: Physics in Medicine and Biology. 56:3731-3748

The (83)Kr magnetic resonance (MR) relaxation time T(1) of krypton gas in contact with model surfaces was previously found to be highly sensitive to surface composition, surface-to-volume ratio, and surface temperature. The work presented here explor

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https://doi.org/10.1088/0031-9155/56/13/001

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Xanthine Oxidoreductase Promotes the Inflammatory State of Mononuclear Phagocytes through Effects on Chemokine Expression, Peroxisome Proliferator-activated Receptor-γ Sumoylation, and HIF-1α

Autor: Richard M. Wright, Mari E. Weyman, Mehdi A. Fini, Gayle N. Shibao, Hillary Fitzgerald, Nancy D. Elkins, Janice Tiao, Sophie Gibbings

Publikováno v: Gibbings, S, Elkins, N D, Fitzgerald, H, Tiao, J, Weyman, M E, Shibao, G, Fini, M A & Wright, R M 2011, ' Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1 alpha ', Journal of Biological Chemistry, vol. 286, no. 2, pp. 961-975 . https://doi.org/10.1074/jbc.M110.150847

The protective effects of pharmacological inhibitors of xanthine oxidoreductase (XOR) have implicated XOR in many inflammatory diseases. Nonetheless, the role played by XOR during inflammation is poorly understood. We previously observed that inhibit

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https://doi.org/10.1074/jbc.m110.150847

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α-4/β-1 and α-L/β-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injury

Autor: Richard M. Wright, Parmley La, Liu Ye, Nancy D. Elkins, Mehdi A. Fini, John E. Repine

Publikováno v: British Journal of Pharmacology. 152:915-929

Background and purpose: Injury to the alveolar epithelium is a critical feature of acute lung injury (ALI). Using a cytokine model of ALI we demonstrated previously that newly recruited mononuclear phagocytes (MNP) contributed to lung inflammation an

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https://doi.org/10.1038/sj.bjp.0707443

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Mononuclear Phagocyte Xanthine Oxidoreductase Contributes to Cytokine-Induced Acute Lung Injury

Autor: Noi Kosila, Richard M. Wright, Brendan Essary, James L. McManaman, Lisa A. Ginger, John E. Repine, Nancy D. Elkins

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 30:479-490

Acute lung injury (ALI) is characterized by increased alveolar cytokines, inflammatory cell infiltration, oxidative stress, and alveolar cell apoptosis. Previous work suggested that xanthine oxidoreductase (XOR) may contribute to oxidative stress in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135ccabec721ce168f05ddb76bbe7549
https://doi.org/10.1165/rcmb.2003-0309oc

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Preventing the Acute Respiratory Distress Syndrome

Autor: Paul Wilson, Katrina M. Crader, Jonathan J. D. Repine, John E. Repine, Nancy D. Elkins

Publikováno v: Preventive Medicine. 54:S17-S19

Laudable supportive advances have been made to improve the care of patients with the Acute Respiratory Distress Syndrome (ARDS) but no pharmacologic interventions are known to reduce the high mortality of this disorder once it is established. This co

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https://doi.org/10.1016/j.ypmed.2011.12.007

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Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats

Autor: Luke Domaleski, Qianbin He, Nancy D. Elkins, Paul E. Wischmeyer, John E. Repine, Ana Fernandez-Bustamante, Amanda Agazio, Paul F. Wilson, Angela Moss, Kaily A. Baer

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0130764 (2015)

Background Glutamine (GLN) attenuates acute lung injury (ALI) but its effect on alveolar macrophages is unknown. We hypothesized that GLN pretreatment would induce the anti-inflammatory CD163/heme oxygenase (HO)-1/p38-MAPK dephosphorylation pathway i

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https://pubmed.ncbi.nlm.nih.gov/26147379

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Effects of acetate on energy metabolism and function in the isolated perfused rat heart

Autor: Nancy D. Elkins, Joseph I. Shapiro, Oscar K. Reiss, Alexis D. Jacob, Laurence Chan

Publikováno v: Kidney International. 52(3):755-760

Effects of acetate on energy metabolism and function in the isolated perfused rat heart. Impairment of cardiac contractile function is an important component of acetate associated hypotension during hemodialysis treatments. We examined the effect of

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