Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nancy C. Kupina"'
Publikováno v:
Journal of Neurotrauma. 21:9-20
The role of reactive oxygen-induced oxidative damage to lipids (i.e., lipid peroxidation, LP) and proteins has been strongly supported in previous work. Most notably, a number of free radical scavengers and lipid antioxidants have been demonstrated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8251ef891e67716e20812b7803d2302a
https://doi.org/10.1089/089771504772695904
https://doi.org/10.1089/089771504772695904
Publikováno v:
Experimental Neurology. 180:55-73
The resulting neuropathological degeneration that occurs following a traumatic brain injury (TBI) is a consequence of both immediate and secondary neurochemical sequelae. Proteolysis of cytoskeletal proteins, triggered by calcium-mediated events, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cf4673173b3f33fb15954b4eefda69
https://doi.org/10.1016/s0014-4886(02)00048-1
https://doi.org/10.1016/s0014-4886(02)00048-1
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 22:1212-1221
The authors present two studies that investigate the biochemical and histologic effects of the nonimmunosuppressive neuroimmunophilin (NIMM) ligand V-10,367 in a mouse model of traumatic brain injury (TBI). In study 1, the authors examined the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f5e355c09f77183edbbc1252469f56
https://doi.org/10.1097/01.wbc.0000037994.34930.bc
https://doi.org/10.1097/01.wbc.0000037994.34930.bc
Autor:
Gerald P. Schielke, Albert W. Probert, Xiaodong Ren, Nancy C. Kupina, Megan Davis, Kevin K.W. Wang, Rathna Nath
Publikováno v:
Biochemical and Biophysical Research Communications. 274:16-21
Recently, it was shown that conversion of cdk5 activator protein p35 to a C-terminal fragment p25 promotes a deregulation of cdk5 activity, which may contribute to neurodegeneration in Alzheimer's disease. In this study, we present evidence that calp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204651d0436c05384f4150b667e9c991
https://doi.org/10.1006/bbrc.2000.3070
https://doi.org/10.1006/bbrc.2000.3070
Autor:
Charles Taylor, Kadee J. Raser, Avigail Posner, John J. Cordon, Kevin K.W. Wang, Nancy C. Kupina, Gerald P. Schielke, Mark G. Vartanian
Publikováno v:
Developmental Brain Research. 95:169-175
This study was performed to investigate whether the anticonvulsant phenytoin has neuroprotective effect in a model of hypoxia-ischemia with neonatal rats. The left carotid artery of each rat was ligated, followed by 3 h of hypoxic exposure (8% O2) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a1d84614dfd418b600448726953bea
https://doi.org/10.1016/0165-3806(96)00073-9
https://doi.org/10.1016/0165-3806(96)00073-9
Publikováno v:
Brain Research. 564:328-331
We used a polyclonal antiserum directed against calpain II to study the distribution of that enzyme in rat sciatic nerve. Western blot of nerve homogenate showed that the antibody reacted with a single protein band of 80 kDa, corresponding to the cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bb1fd83966a2124e7e389626870ac5
https://doi.org/10.1016/0006-8993(91)91471-c
https://doi.org/10.1016/0006-8993(91)91471-c
Autor:
Kevin K.W. Wang, Nancy C. Kupina, Colleen Meegan, Ronald L. Hayes, Ming Cheng Liu, Eric E. Bernath
Publikováno v:
Neurobiology of aging. 27(4)
Previous studies indicated there is an overall increase of proteolysis in aging rat brains. We monitored the potential degradation of cytoskeletal proteins in neuronal tissue taken from cerebral cortex and cerebellum of young (3 month) and aging (17,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e95a53c5be81b203ab9ed922ba9efc2
https://pubmed.ncbi.nlm.nih.gov/15913844
https://pubmed.ncbi.nlm.nih.gov/15913844
Autor:
Jun Inoue, Edward D. Hall, Azuma Mitsuyoshi, Rathna Nath, Eric E. Bernath, Po-Wai Yuen, Kevin K.W. Wang, Nancy C. Kupina
Publikováno v:
Journal of neurotrauma. 18(11)
A principal mechanism of calcium-mediated neuronal injury is the activation of neutral proteases known as calpains. Proteolytic substrates for calpain include receptor and cytoskeletal proteins, signal transduction enzymes and transcription factors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45877a6aa5d04cf4b998288f3f4e1e1
https://pubmed.ncbi.nlm.nih.gov/11721741
https://pubmed.ncbi.nlm.nih.gov/11721741
Publikováno v:
Annals of the New York Academy of Sciences. 890
Recent evidence has suggested that the superoxide and nitric oxide-derived reactive oxygen species peroxynitrite (ONOO-) may play a significant role in the acute pathophysiology of brain injury. One pharmacological mechanism by which ONOO(-)-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf86a2bfd04d007bd138131ef72eed1
https://pubmed.ncbi.nlm.nih.gov/10668450
https://pubmed.ncbi.nlm.nih.gov/10668450
Autor:
Brenda D. Shivers, Karen M. Keane, John P. Vasilakos, Peter A. Boxer, Toni Lynch, Gerald P. Schielke, Nancy C. Kupina, Mark G. Vartanian
Publikováno v:
Annals of the New York Academy of Sciences. 840
The ICE family of cysteine proteases mediates necrotic or apoptotic events in the nervous system as well as in other tissues. This suggests that inhibitors may be of therapeutic value in acute and, perhaps, chronic neurode-generative disease. In addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8bc9b3887a3c8fb5aef5b364651170
https://pubmed.ncbi.nlm.nih.gov/9629237
https://pubmed.ncbi.nlm.nih.gov/9629237