Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Nancy C. Hancock"'
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Akademický článek
Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis
Autor: Luke A. Miles, Stefan J. Hermans, Gabriela A.N. Crespi, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero, Jasmina Markulić, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andrés A. Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C. Hancock, Michael W. Parker
Publikováno v: iScience, Vol 19, Iss , Pp 110-118 (2019)
Summary: Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might be an effective therapy aga
Externí odkaz: https://doaj.org/article/22f8a82eaea94df5bb89f782ed04cc2d
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2
Structural biology of cell surface receptors implicated in Alzheimer’s disease
Autor: Kenta Ishii, Jonathan H. Gooi, S.J. Hermans, Chen Gao, Gabriela A. N. Crespi, Jasmina Markulić, Nancy C. Hancock, Michael W. Parker, Tracy L. Nero, Craig J. Morton
Publikováno v: Biophys Rev
Alzheimer’s disease is a common and devastating age-related disease with no effective disease-modifying treatments. Human genetics has implicated a wide range of cell surface receptors as playing a role in the disease, many of which are involved in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e130c0175c58d64afc330b3ac61c9a
https://europepmc.org/articles/PMC8921391/
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3
Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis
Autor: Andreas Ebneth, Luke A. Miles, S.J. Hermans, Marie-Laure Rives, Daniel Oehlrich, Berthold Wroblowski, Jasmina Markulić, Michael W. Parker, Ines Royaux, Nancy C. Hancock, Gabriela A. N. Crespi, Andrés A. Trabanco, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero
Publikováno v: iScience, Vol 19, Iss, Pp 110-118 (2019)
iScience
Summary Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might be an effective therapy agai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7151465d056dc1c6d6d54d24ff249c
http://www.sciencedirect.com/science/article/pii/S2589004219302482
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4
Development of [
Autor: Siu Wai, Wong, Lucy, Vivash, Ramesh, Mudududdla, Nghi, Nguyen, Stefan J, Hermans, David M, Shackleford, Judith, Field, Lian, Xue, Andrea, Aprico, Nancy C, Hancock, Mohammad, Haskali, Michael A, Stashko, Stephen V, Frye, Xiaodong, Wang, Michele D, Binder, Uwe, Ackermann, Michael W, Parker, Trevor J, Kilpatrick, Jonathan B, Baell
Publikováno v: European journal of medicinal chemistry. 226
MER tyrosine kinase (MERTK) upregulation is associated with M2 polarization of microglia, which plays a vital role in neuroregeneration following damage induced by neuroinflammatory diseases such as multiple sclerosis (MS). Therefore, a radiotracer s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea044071cb613468cbef9f4ec7ab324d
https://pubmed.ncbi.nlm.nih.gov/34563964
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6
A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1
Autor: Nancy C. Hancock, Mario Lo Bello, Anastasia De Luca, Wee Han Ang, Paul J. Dyson, A.P. Mazzetti, Michael W. Parker, Francesca Palone, Lorien J. Parker, Laure Menin, Valentina Gabbarini, Craig J. Morton, Carlo Rodolfo
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance The resurgence of platinum-based chemotherapy in the last few years has renewed interest in the field, including clinical studies of cisplatin in combination with resistance modulators. Indeed, cisplatin is one of the most successful ant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e40951ecdd8d8bf8d32f06f84c826ae
http://hdl.handle.net/2108/215066
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8
Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides
Autor: Nancy C. Hancock, Siew Yeen Chai, Michael W. Parker, Jessica K. Holien, S.J. Hermans, David B. Ascher, Craig J. Morton, Belinda J. Michell
Publikováno v: Protein Science. 24:190-199
Insulin-regulated aminopeptidase (IRAP or oxytocinase) is a membrane-bound zinc-metallopeptidase that cleaves neuroactive peptides in the brain and produces memory enhancing effects when inhibited. We have determined the crystal structure of human IR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f67736010f83b22a2b754e1fc5acaaca
https://doi.org/10.1002/pro.2604
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10
Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2
Autor: T. John Martin, David T. Manallack, Nancy C. Hancock, Patricia W. M. Ho, Ian G. Jennings, Jessica K. Holien, Hooi-Ling Ng, Craig J. Morton, Susanne C. Feil, Jacob L. Nankervis, Philip E. Thompson, Mark Frazzetto, Michael W. Parker, Zhaohua Zheng
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:7089-7093
PDE4 inhibitors have been identified as therapeutic targets for a variety of conditions, particularly inflammatory diseases. We have serendipitously identified a novel class of phosphodiesterase 4 (PDE4) inhibitor during a study to discover antagonis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9151dd8cd0212547ca40e0e744bbc78d
https://doi.org/10.1016/j.bmcl.2011.09.109
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