Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nancy Bump"'
Autor:
Xingyue He, Mark G. Qian, Matthew O. Duffey, Larry Cohen, Michael D. Sintchak, Mi-Sook Kim, Jessica Riceberg, Vaishali Shindi, Kelly Connolly, Jianping Guo, Agatha Zawadzka, Rachel E. Gershman, Teresa A. Soucy, Neil Bence, Zhigen Hu, Xiaofeng Yang, Shumet A. Hailu, Nina Molchinova, Nanda Gulavita, Ji Zhang, Hirotake Mizutani, Keli Song, A D Patil, Scott Freeze, Jessica Grieves, Dylan Bradley England, Roushan Afroze, James J. Minissale, Anya Lublinsky, Mitsuhiro Ito, David Lok, Scott Weston Lane, William D. Mallender, Stephen Grossman, Kara Hoar, Nitya Durvasula, Bei-Ching Chuang, Yongbo Hu, Steven P. Langston, Sai M. Pulukuri, Miho Mizutani, Ryan Chau, Nancy Bump, Katherine M. Galvin, Christopher F. Claiborne, Paul D. Greenspan, He Xu, Gaulin Jeffrey L, Melissa Gallery, Douglas Bowman, Yana Wang, Koji Ono, Mcintyre Charles
Publikováno v:
Journal of medicinal chemistry. 64(5)
SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5159f216a3701336ba4dda4e3a9836
https://pubmed.ncbi.nlm.nih.gov/33631934
https://pubmed.ncbi.nlm.nih.gov/33631934
Autor:
Edward J. Olhava, Paul Hales, Cynthia Barrett, Jane X. Liu, Matthew Jones, Frank J. Bruzzese, Kenneth M. Gigstad, Khristofer Garcia, Christopher Tsu, Darshan S. Sappal, Teresa A. Soucy, Paul E. Fleming, Christopher Blackburn, Michael D. Sintchak, Jonathan L. Blank, Nancy Bump, Lawrence R. Dick
Publikováno v:
Biochemical Journal
The mammalian 26S proteasome is a 2500 kDa multi-catalytic complex involved in intracellular protein degradation. We describe the synthesis and properties of a novel series of non-covalent di-peptide inhibitors of the proteasome based [corrected] on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f48642b351f04b2dc37016661e3f601
https://doi.org/10.1042/bj20100383
https://doi.org/10.1042/bj20100383
Autor:
Kenneth M. Gigstad, Khristofer Garcia, Paul Hales, Nancy Bump, Frank J. Bruzzese, Paul E. Fleming, Lawrence R. Dick, Zhigen Hu, Christopher Blackburn, Matthew Jones, Christopher Tsu, Michael D. Sintchak, Cynthia Barrett, Jane X. Liu, Jonathan L. Blank, Darshan S. Sappal
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
Starting from a tripeptide screening hit, a series of dipeptide inhibitors of the proteasome with Thr as the P3 residue has been optimized with the aid of crystal structures in complex with the β-5/6 active site of y20S. Derivative 25, (β5 IC(50)=7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed960939ca4ea0080006c362ffe95f3
https://pubmed.ncbi.nlm.nih.gov/20875739
https://pubmed.ncbi.nlm.nih.gov/20875739
Autor:
Anne L. Burkhardt, Michael Milhollen, Xiaofeng Yang, Huay-Keng Loke, Lawrence R. Dick, Teresa A. Soucy, Irache Visiers, Frank J. Bruzzese, Michael D. Sintchak, James J. Spelman, Steven P. Langston, Ping Li, Kristin B. Hamman, James M. Gavin, Joseph B. Bolen, Nancy Bump, Sells Todd B, Jingya Ma, Christopher F. Claiborne, Stepan Vyskocil, Courtney Cullis, Hua Liao, Mark Rolfe, Dongyun Wu, James E. Brownell, Trupti Lingaraj, William D. Mallender
Publikováno v:
Molecular cell. 37(1)
The NEDD8-activating enzyme (NAE) initiates a protein homeostatic pathway essential for cancer cell growth and survival. MLN4924 is a selective inhibitor of NAE currently in clinical trials for the treatment of cancer. Here, we show that MLN4924 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1c0384688095b5fb058f1a119b3019
https://pubmed.ncbi.nlm.nih.gov/20129059
https://pubmed.ncbi.nlm.nih.gov/20129059
Autor:
Nancy Bump, Cindy Q. Xia, Lawrence R. Dick, Paul Hales, Frank J. Bruzzese, Cynthia Barrett, Darshan S. Sappal, Kenneth M. Gigstad, Khristofer Garcia, Jane X. Liu, Christopher Blackburn, Jonathan L. Blank, Paul E. Fleming, Masayuki Nagayoshi, Michael D. Sintchak, Christopher Tsu, Matthew Jones, Xiansi Zhou
Publikováno v:
MedChemComm. 3:710
Inhibition of the proteasome by covalent inhibitors is a clinically proven anti-cancer therapy. We report here that dipeptides with a P3 neopentyl Asn residue are potent, reversible, non-covalent inhibitors selective for the chymotryptic activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31a337948e93755309d48a1aa562b07
https://doi.org/10.1039/c2md20060k
https://doi.org/10.1039/c2md20060k
Autor:
Christopher Blackburn, Kenneth M. Gigstad, Paul Hales, Khristofer Garcia, Matthew Jones, Frank J. Bruzzese, Cynthia Barrett, Jane X. Liu, Teresa A. Soucy, Darshan S. Sappal, Nancy Bump, Edward J. Olhava, Paul Fleming, Lawrence R. Dick, Christopher Tsu, Michael D. Sintchak, Jonathan L. Blank
Publikováno v:
Biochemical Journal; Aug2010, Vol. 430 Issue 3, p461-476, 16p
Autor:
Southwood, Nicholas1 nfs@coombs.anu.edu.au, Friedrich, Daniel1 danielf@coombs.anu.edu.au
Publikováno v:
Philosophical Studies. May2009, Vol. 144 Issue 2, p261-280. 20p.
Autor:
Erik Mortenson
In Turkey the Beat message of dissent is being given renewed life as publishers, editors, critics, readers, and others dissatisfied with the conservative social and political trends in the country have turned to the Beats and other countercultural fo
A collection of previously unpublished writing culled from the Kerouac archive Jack Kerouac's archive is vast. Throughout his life he was constantly writing, and he meticulously saved and catalogued his material. The result is that beyond the work p
Truth and Beautiful Meaningful Lies is a collection of memorable quotes from one of the most quoted writers in American literature.One of the most celebrated writers in American literature, Jack Kerouac helped an entire generation of post-WWII Americ