Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nancy Boman"'
Autor:
Euan Ramsay, Dana Masin, Donald T. T. Yapp, Nancy Boman, Murray S. Webb, Gigi N.C. Chiu, Pieter R. Cullis, Marcel B. Bally
Publikováno v:
Letters in Drug Design & Discovery. 4:426-433
Autor:
Patricia M. Logan, Murray S. Webb, Kym Sutton, David J. Wiseman, Dawn Saxon, Nancy Boman, Kim F. Wong, Michael J. Hope
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:45-52
The fluoroquinolone antibiotic ciprofloxacin has been encapsulated into large unilamellar vesicles (LUV) at efficiencies approaching 100%. Drug accumulation proceeded in response to a transmembrane gradient of methylammonium sulfate and occurred conc
Publikováno v:
Cancer Chemotherapy and Pharmacology. 37:351-355
A problem associated with the intravenous delivery of vincristine concerns drug extravasation at the site of injection or infusion. This can result in extensive local soft-tissue damage. A new formulation of vincristine has recently been developed ba
Publikováno v:
Journal of Liposome Research. 5:523-541
Vincristine is a potent therapeutic agent with activity against a variety of tumor types. It is a cell-cycle specific agent which has exhibited enhanced anti-tumor activity when delivered in liposomal form. Vincristine can be encapsulated into large
Publikováno v:
Long Circulating Liposomes: Old Drugs, New Therapeutics ISBN: 9783662221174
Vincristine is an alkaloid derived from Vinca rosea that is effective against a wide variety of human carcinomas.1,2 When used in conjunction with corticosteroids, vincristine is the treatment of choice to induce remissions in childhood leukemia. Vin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6beae00a779d0677b4ed868bf52035ea
https://doi.org/10.1007/978-3-662-22115-0_3
https://doi.org/10.1007/978-3-662-22115-0_3
Publikováno v:
Journal of drug targeting. 4(3)
Doxorubicin is a potent antineoplastic agent with activity against numerous human cancers. Encapsulation of doxorubicin inside a liposome alters bioavailability, biodistribution and thus its biological activity significantly. The physical properties
Publikováno v:
British Journal of Cancer
Vincristine pharmacokinetic, tumour uptake and therapeutic characteristics were investigated here in order to elucidate the processes underlying the enhanced efficacy observed for vincristine entrapped in small (120 nm) distearoylphosphatidylcholine/
Publikováno v:
Biochimica et biophysica acta. 1152(2)
The influence of lipid composition, internal pH and internal buffering capacity on the retention properties of vincristine loaded into large unilamellar vesicle (LUV) systems in response to transmembrane pH gradients has been assessed. It is shown th
Autor:
Lawrence D. Mayer, Robert L. Thies, Pieter R. Cullis, Nancy Boman, Marcel B. Bally, Rajiv Nayar
Publikováno v:
Cancer chemotherapy and pharmacology. 33(1)
The influence of vesicle lipid composition, size and drug-to-lipid ratio on the antitumour activity of liposomal vincristine was assessed in the murine L1210 ascitic leukemia model. A pH gradient-dependent entrapment procedure was used to encapsulate
Autor:
Nancy Boman, David B. Fenske, Kim F. Wong, Norbert Maurer, Johanna Maria Leenhouts, Elisabeth Maurer, Lawrence N. Amankwa, Pieter R. Cullis
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (1-2):188-204
A new method, based on the ion-translocating properties of the ionophores nigericin and A23187, is described for loading large unilamellar vesicles (LUVs) with the drugs vincristine and ciprofloxacin. LUVs composed of distearoylphosphatidylcholine/ch