Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Nancy B. Sussman"'
Publikováno v:
Computer Methods and Programs in Biomedicine. 77:199-207
Recent works on covariate measurement errors focus on the possible biases in model coefficient estimates. Usually, measurement error in a covariate tends to attenuate the coefficient estimate for the covariate, i.e., a bias toward the null occurs. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1b33c6b8b0b9c3f114b77311f894b9
https://doi.org/10.1016/j.cmpb.2004.09.006
https://doi.org/10.1016/j.cmpb.2004.09.006
Publikováno v:
Computer Methods and Programs in Biomedicine. 72:81-87
The process of assessing the prediction ability of a computational model is called model validation. For models predicting a categorical response, the prediction ability is usually quantified by prediction measures such as sensitivity, specificity, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b05c4f251c2c927b000c8ccd886c6a9
https://doi.org/10.1016/s0169-2607(02)00119-0
https://doi.org/10.1016/s0169-2607(02)00119-0
Publikováno v:
SAR and QSAR in Environmental Research. 14:83-96
Humans are exposed to thousands of environmental chemicals for which no developmental toxicity information is available. Structure-activity relationships (SARs) are models that could be used to efficiently predict the biological activity of potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8748e3320fb49d1779225c69cfc952d8
https://doi.org/10.1080/1062936031000073126
https://doi.org/10.1080/1062936031000073126
Autor:
Qing Zhao, Claudette M. St. Croix, Jianfei Jiang, Nancy B. Sussman, Valerian E. Kagan, Bruce R. Pitt
Publikováno v:
Chemical Research in Toxicology. 15:1080-1087
Glutathione (GSH) and metallothioneins (MT) are believed to play important roles in protecting cells against high copper (Cu) concentrations. Little is known, however, about their specific intracellular interactions and the coordination of protective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f48a8f7ec7ba43cb8d40e19a7e37c3
https://doi.org/10.1021/tx020022u
https://doi.org/10.1021/tx020022u
Physicochemical and Graph Theoretical Descriptors in Developmental Toxicity SAR: A Comparative Study
Publikováno v:
SAR and QSAR in Environmental Research. 11:345-362
Chemical insults to the developing fetus can lead to growth retardation, malformation, death, and functional deficits. The present study seeks to determine if physicochemical and/or graph theoretical parameters can be used to determine a structure-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad5e9491b4b1e1201c0083939590e95
https://doi.org/10.1080/10629360108035358
https://doi.org/10.1080/10629360108035358
Publikováno v:
Quantitative Structure-Activity Relationships. 19:467-474
SAR model development should be a continuous process involving formulation then experimental testing of the model, incorporation of test results into the database, then refinement of the model using the expanded database. The larger database affords
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::958530f0985390add5f358189aedd90c
https://doi.org/10.1002/1521-3838(200012)19:5<467::aid-qsar467>3.0.co
https://doi.org/10.1002/1521-3838(200012)19:5<467::aid-qsar467>3.0.co
Autor:
Z D Belyaeva, N D Okladnikova, V S Pesternikova, H.G. Claycamp, B R Scott, S Shekhter-Levin, Igor I. Teplyakov, B B Boecker, Tamara V. Azizova, Nancy B. Sussman, Niel Wald, M V Sumina
Publikováno v:
Health Physics. 79:48-54
Project 2.3 of the Joint Coordinating Committee on Radiation Effects Research (JCCRER) is a study of deterministic health effects among a cohort of Russia nuclear workers. The preliminary study population includes a stratified random sample of 221 ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91de814eab9566d01856628418ec0c5a
https://doi.org/10.1097/00004032-200007000-00009
https://doi.org/10.1097/00004032-200007000-00009
A Robust Structure-Activity Relationship (SAR) Model for Esters that Cause Skin Irritation in Humans
Publikováno v:
Toxicological Sciences. 55:215-222
A structure-activity relationship (SAR) model has been developed to discriminate skin irritant from nonirritant esters. The model is based on the physicochemical properties of 42 esters that were tested in humans for skin irritation. Nineteen physico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21052a5ce2f802280e30007b2d29bcf
https://doi.org/10.1093/toxsci/55.1.215
https://doi.org/10.1093/toxsci/55.1.215
Publikováno v:
American Journal of Industrial Medicine. 36:114-121
Background We present the mortality experience for a cohort of women (n = 2,877) from a large epidemiologic study of production and fabrication high nickel alloys workers (n = 31,165). All the plants were located within the United States and cohort e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7db82d918db09612f75c428e1df4ee8
https://doi.org/10.1002/(sici)1097-0274(199907)36:1<114::aid-ajim16>3.0.co
https://doi.org/10.1002/(sici)1097-0274(199907)36:1<114::aid-ajim16>3.0.co
Autor:
H. Gregg Claycamp, Nancy B. Sussman
Publikováno v:
Quantitive Structure-Activity Relationships. 18:11-15
The objective of many SAR or QSAR experiments is to develop statistical classification models that can separate chemicals into classes of “active” or “inactive” under a toxicological endpoint. Several existing statistical methods are often us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9404d258bdc21f4b233624c0f0655ec5
https://doi.org/10.1002/(sici)1521-3838(199901)18:1<11::aid-qsar11>3.0.co
https://doi.org/10.1002/(sici)1521-3838(199901)18:1<11::aid-qsar11>3.0.co