Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nancy Bélanger"'
Autor:
Abdallah Hadj Tahar, Laurent Grégoire, Aurélie Darré, Nancy Bélanger, Leonard Meltzer, Paul J Bédard
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 2, Pp 171-176 (2004)
Alterations of striatal glutamate receptors are believed to be responsible, at least in part, for the pathogenesis of l-dopa-induced dyskinesias (LID). To evaluate whether co-administration of CI-1041, a novel NMDA receptor antagonist selective for t
Externí odkaz:
https://doaj.org/article/174938850bc84fccb7c87fec083593f2
Autor:
Abdallah Hadj-Tahar, Robert A. Hodgson, Thérèse Di Paolo, Tatiana M. Kazdoba, Andrew Stamford, Paul J. Bédard, Annamarie Pond, Aurelie Dare, Laurent Grégoire, John C. Hunter, Geoffrey B. Varty, Michael Grzelak, Bernard R. Neustadt, Nancy Bélanger
Publikováno v:
Experimental Neurology. 225:384-390
Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Aden
Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 34:446-454
L-Dopa treatment, the gold standard therapy for Parkinson's disease, is hampered by motor complications such as dyskinesias. Recently, impairment of striatal Akt/GSK3 signaling was proposed to play a role in the mechanisms implicated in development o
Autor:
Leonard T. Meltzer, Thérèse Di Paolo, Pershia Samadi, Frédéric Calon, Laurent Grégoire, Abdallah Hadj Tahar, Nancy Bélanger, Paul J. Bédard, Marc Morissette, Mehdi Dridi
Publikováno v:
Neurobiology of Aging. 29:1040-1051
Modulation of excessive glutamatergic transmission within the basal ganglia is considered as an alternative approach to reduce l-Dopa-induced dyskinesias (LIDs) in Parkinson's disease (PD). In this study receptor binding autoradiography of [3H]MPEP,
Publikováno v:
Neurobiology of Aging. 27:1684-1693
The steroid dehydroepiandrosterone (DHEA) is abundant in men and women and decreases rapidly during aging. Parkinson's disease (PD) is the second most common neurodegenerative disorder just behind Alzheimer. l-3,4-Dihydroxyphenylalanine (l-Dopa) ther
Autor:
Paul J. Bédard, Richard Grondin, Abdallah Hadj Tahar, Pershia Samadi, Pierre J. Blanchet, Leonard T. Meltzer, Marc Morissette, Frédéric Calon, Laurent Grégoire, Thérèse Di Paolo, Nancy Bélanger
Publikováno v:
Parkinsonism & Related Disorders. 10:297-304
For nearly 20 years, the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model has allowed great strides to be made in our understanding of the maladaptive changes underlying the levodopa-related motor response complications occurring in
Publikováno v:
Movement Disorders. 18:1436-1441
Levodopa continues to be the most effective agent for the symptomatic treatment of Parkinson's disease (PD). But over time, initial benefits decline in efficacy because of a rise in adverse effects such as dyskinesias. The pathophysiology of levodopa
Autor:
Nancy Bélanger, Stéphan Desrochers
Publikováno v:
British Journal of Developmental Psychology. 19:11-21
Two experiments investigated 6-month-old infants’ processing of causal and noncausal events with the habituation/dishabituation technique. Experiment 1 was carried out with the usual launching events. Results showed that 6-month-old infants can rec
Autor:
Marc Morissette, Nancy Bélanger, Erika Estrada-Camarena, Maria Gabriela Sánchez, Thérèse Di Paolo
Publikováno v:
Neuropharmacology. 60(4)
Depression is common in Parkinson’s disease and an imbalance in serotonin neurotransmission could be implicated. Estradiol is reported to modulate brain serotonin systems of rodents and monkeys, but this has not been explored in primate models of P
Autor:
Pershia Samadi, Marc Morissette, Thérèse Di Paolo, Nancy Bélanger, Mehdi Dridi, Frédéric Calon, Paul J. Bédard, Abdallah Hadj Tahar, Leonard T. Meltzer
Publikováno v:
Synapse (New York, N.Y.). 62(2)
L-Dopa therapy in Parkinson's disease (PD) is counfounded by the development of involuntary movements such as L-Dopa-induced dyskinesias (LIDs). In this study GABA(A) receptor autoradiography was assessed using [(3)H]flunitrazepam binding to the benz