Výsledky vyhledávání - "Nancy Ann Hosken"

Stability of live attenuated rotavirus vaccine with selected preservatives and primary containers

Autor: Nancy Ann Hosken, Chris L. McClurkan, Changcheng Zhu, David M. Koelle, Manjari Lal, Andrew Roehrig, Eugene Saxon, Dexiang Chen, Darin Zehrung, Courtney Jarrahian

Publikováno v: Vaccine. 34:2483-2489

Rotavirus infection, which can be prevented by vaccination, is responsible for a high burden of acute gastroenteritis disease in children, especially in low-income countries. An appropriate formulation, packaging, and delivery device for oral rotavir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28f4119e59e9b771b32e56bf3e2d47d
https://doi.org/10.1016/j.vaccine.2016.03.093

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Serum and mucosal antibody responses to inactivated polio vaccine after sublingual immunization using a thermoresponsive gel delivery system

Autor: David M. Koelle, Lauren Duncan, Nancy Ann Hosken, Jeremy S. Blum, M. Steven Oberste, Dexiang Chen, John D. Clements, Manjari Lal, Elizabeth B. Norton, Changcheng Zhu, Joshua O. Marshak, Jessica A. White, William C. Weldon

Publikováno v: Human Vaccines & Immunotherapeutics

Administering vaccines directly to mucosal surfaces can induce both serum and mucosal immune responses. Mucosal responses may prevent establishment of initial infection at the port of entry and subsequent dissemination to other sites. The sublingual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4079772718df322936736aaa4f5ab7af
http://europepmc.org/articles/PMC4514067

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Diversity of the CD8+T-Cell Response to Herpes Simplex Virus Type 2 Proteins among Persons with Genital Herpes

Autor: Patrick Mcgowan, David M. Koelle, Nancy Ann Hosken, Paul R. Sleath, Felecia Wagener, Amalia Meier, Lawrence Corey, Ken Grabstein, Mark Elliott, Christine M. Posavad

Publikováno v: Journal of Virology. 80:5509-5515

Cytolytic T cells play a major role in controlling herpes simplex virus type 2 (HSV-2) infections in humans. In an effort to more thoroughly evaluate the response to HSV-2 directly, ex vivo, we developed an enzyme-linked immunospot (ELISPOT) assay th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b3458a0cf9ebc34c26adf8fa125825
https://doi.org/10.1128/jvi.02659-05

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Development of a therapeutic vaccine for HSV-2

Autor: Nancy Ann Hosken

Publikováno v: Vaccine. 23:2395-2398

A therapeutic vaccine for genital herpes is clearly needed. Vaccines recently developed for HSV-2 in humans have been aimed at eliciting CD4+ T cell responses and neutralizing antibody responses to two HSV-2 glycoproteins (gB and gD). These vaccines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2450b5dea3900ceceba35b6f53c4b48
https://doi.org/10.1016/j.vaccine.2005.01.017

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Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

Autor: Kenneth M. Murphy, Kazuko Shibuya, K Davis, Erin Murphy, Maino, Anne O'Garra, Peter J. M. Openshaw, Nancy Ann Hosken

Publikováno v: The Journal of Experimental Medicine

Commitment of T helper 1 (Th1) or Th2 populations developing during an immune response to a pathogen, or an inappropriate immune response to an allergen or autoantigen, may determine the difference between health and chronic disease. We show that str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c287631c7b25d6a3de9bae99204c8dd
https://doi.org/10.1084/jem.183.3.901

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Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects

Autor: Christian Pelte, Paul R. Sleath, Bridget L. Mitchell, John B. Edgar, Florian Kern, Andrew W. Sylwester, Jay A. Nelson, Cara Taormina, Kenneth H. Grabstein, Nancy Ann Hosken, Franziska Ruchti, Louis J. Picker

Publikováno v: The Journal of Experimental Medicine

Human cytomegalovirus (HCMV) infections of immunocompetent hosts are characterized by a dynamic, life-long interaction in which host immune responses, particularly of T cells, restrain viral replication and prevent disease but do not eliminate the vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e546830b7f5ed4705360c9ff13452188
https://pubmed.ncbi.nlm.nih.gov/16147978

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Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor

Autor: Anna Wald, Jeffrey Vieira, Christopher L. McClurkan, Zhi Liu, Clement A. Meseda, David M. Koelle, Nancy Ann Hosken, Devon C. Snow, Lawrence Corey, Randal C. Cevallos

The study of immunodominance within microbe-specific CD8 T cell responses has been challenging. We used a previously undescribed approach to create unbiased panels of CD8 cytotoxic T lymphocyte clones specific for herpes simplex virus type 2, a patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2b38e93f1bfa8babad91d5d62c0d05
https://europepmc.org/articles/PMC240716/

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Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3)

Autor: Xiaoyan Wu, N.-X. Yu, J C Grimaldi, Nancy Ann Hosken, Douglas S. Robinson, R L Coffman, Anne O'Garra, B. W. P. Seymour, G. Grunig, Walter Ferlin, Maureen Howard, Françoise Cottrez, H. Soto

Publikováno v: Scopus-Elsevier

We have generated rat monoclonal antibodies specific for the mouse eotaxin receptor, C-C chemokine receptor 3 (CCR3). Several anti-CCR3 mAbs proved to be useful for in vivo depletion of CCR3-expressing cells and immunofluorescent staining. In vivo CC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed9cd05376bba31ca6ebeb2028b01f3
https://pubmed.ncbi.nlm.nih.gov/10380909

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