Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Nancy A. Woychik"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mycobacterium abscessus (Mab) infections are inexplicably intractable to clearing after aggressive and lengthy treatment regimens. Here we discovered that acquisition of a single toxin-antitoxin system enables Mab to activate a phenotypic sw
Externí odkaz:
https://doaj.org/article/9d2e2d7921d843619092d07f5f30bbe4
Autor:
Valdir C. Barth, Ju-Mei Zeng, Irina O. Vvedenskaya, Ming Ouyang, Robert N. Husson, Nancy A. Woychik
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
MazF endoribonucleases are thought to arrest growth of Mycobacterium tuberculosis by global translation inhibition. Here, Barth et al. show that MazF-mt9 cleaves a specific tRNA, leading to ribosome stalling at AAA codons and thus selective mRNA degr
Externí odkaz:
https://doaj.org/article/f04dbec7370047aab331fe63b011becb
Publikováno v:
Frontiers in Genetics, Vol 10 (2020)
Survival of mycobacteria, both free-living and host-dependent pathogenic species, is dependent on their ability to evade being killed by the stresses they routinely encounter. Toxin-antitoxin (TA) systems are unique to bacteria and archaea and are th
Externí odkaz:
https://doaj.org/article/ca4380390bd147759f1646e6c4ea78d9
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
The Mycobacterium tuberculosis genome contains an abundance of toxin-antitoxin (TA) systems, 50 of which belong to the VapBC family. The activity of VapC toxins is controlled by dynamic association with their cognate antitoxins—the toxin is inactiv
Publikováno v:
Antimicrob Agents Chemother
The Mycobacterium tuberculosis genome contains an abundance of toxin-antitoxin (TA) systems, 50 of which belong to the VapBC family. The activity of VapC toxins is controlled by dynamic association with their cognate antitoxins—the toxin is inactiv
Autor:
Valdir C. Barth, Jumei Zeng, Haiyan Zheng, Robert N. Husson, Xiaoyang Su, Nancy A. Woychik, Unnati Chauhan
Publikováno v:
Proc Natl Acad Sci U S A
The Mycobacterium tuberculosis (Mtb) VapBC4 toxin–antitoxin system is essential for the establishment of Mtb infection. Using a multitier, systems-level approach, we uncovered the sequential molecular events triggered by the VapC4 toxin that activa
Autor:
Nancy A. Woychik, Robert N. Husson, Ming Ouyang, Valdir C. Barth, Irina O. Vvedenskaya, Ju Mei Zeng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
Mycobacterium tuberculosis readily adapts to survive a wide range of assaults by modifying its physiology and establishing a latent tuberculosis (TB) infection. Here we report a sophisticated mode of regulation by a tRNA-cleaving toxin that enlists h
Autor:
Valdir C. Barth, Nancy A. Woychik, Robert N. Husson, Ju Mei Zeng, Melvilí Cintrón, Jonathan W. Cruz
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
The Mycobacterium tuberculosis genome harbors an unusually high number of toxin-antitoxin (TA) systems. These TA systems have been implicated in establishing the nonreplicating persistent state of this pathogen during latent tuberculosis infection. M
Autor:
Regina Edifor, Nancy A. Woychik, Robert N. Husson, Irina O. Vvedenskaya, Bryce E. Nickels, Jonathan W. Cruz, Jason M. Schifano, Ming Ouyang
Publikováno v:
Nucleic Acids Research
Toxin-antitoxin (TA) systems play key roles in bacterial persistence, biofilm formation and stress responses. The MazF toxin from the Escherichia coli mazEF TA system is a sequence- and single-strand-specific endoribonuclease, and many studies have l
Publikováno v:
Journal of Biological Chemistry. 285:39732-39738
The Mycobacterium tuberculosis genome harbors a striking number (>40) of toxin-antitoxin systems. Among them are at least seven MazF orthologs, designated MazF-mt1 through MazF-mt7, four of which have been demonstrated to function as mRNA interferase