Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nancy A. Pyszczynski"'
Autor:
Debra C. DuBois, Nancy A. Pyszczynski, Richard R. Almon, Diana S. Molano, Justin C. Earp, William J. Jusko
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:546-554
A mechanism-based model for pharmacodynamic effects of dexamethasone (DEX) was incorporated into our model for arthritis disease progression in the rat to aid in identification of the primary factors responsible for edema and bone loss. Collagen-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f624c8077d45c9c85d66253fe22080c5
https://doi.org/10.1124/jpet.108.137414
https://doi.org/10.1124/jpet.108.137414
Publikováno v:
Pharmaceutical Research. 25:769-780
This study examines methylprednisolone (MPL) effects on the dynamics of hepatic low-density lipoprotein receptor (LDLR) mRNA and plasma lipids associated with increased risks for atherosclerosis.Normal male Wistar rats were given 50 mg/kg MPL intramu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdd3d5758b6b6aced3672e54a6bc71d
https://doi.org/10.1007/s11095-007-9371-8
https://doi.org/10.1007/s11095-007-9371-8
Autor:
Peter Heining, Suzette M. Mis, Philip J. Lowe, Guy M. L. Meno-Tetang, Nancy A. Pyszczynski, Hongshan Li, William J. Jusko
Publikováno v:
Drug Metabolism and Disposition. 34:1480-1487
FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) is a new sphingosine-1-phosphate receptor agonist being developed for multiple sclerosis and prevention of solid organ transplant rejection. A physiologically based pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf819c83e1a053e3c13445120794838
https://doi.org/10.1124/dmd.105.009001
https://doi.org/10.1124/dmd.105.009001
Publikováno v:
Journal of Pharmaceutical Sciences. 92:881-889
The results from a quantitative structure-property relationship (QSPR) model was integrated into a fifth-generation pharmacokinetic/pharmacodynamic (PK/PD) model of corticosteroid receptor/gene-mediated effects. The proposed model was developed using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2415a907d800df68a154fd8e14620e1
https://doi.org/10.1002/jps.10343
https://doi.org/10.1002/jps.10343
Autor:
Nancy A. Pyszczynski, Richard R. Almon, Debra C. DuBois, William J. Jusko, Rohini Ramakrishnan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:245-256
An array of adverse steroid effects was examined on a whole body, tissue, and molecular level. Groups of male adrenalectomized Wistar rats were subcutaneously implanted with Alzet mini-pumps giving zero-order release rates of 0, 0.1, and 0.3 mg/kg/h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d15e8352f37a930f95b0b13a63c581
https://doi.org/10.1124/jpet.300.1.245
https://doi.org/10.1124/jpet.300.1.245
Autor:
Nancy A. Pyszczynski, Debra C. DuBois, Richard R. Almon, William J. Jusko, Rohini Ramakrishnan
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 29:1-24
A fifth-generation model for receptor/gene-mediated corticosteroid effects was proposed based on results from a 50 mg/kg IV bolus dose of methylprednisolone (MPL) in male adrenalectomized rats, and confirmed using data from other acute dosage regimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa503e59586a6f7fddf8b2cb0d01bb65
https://doi.org/10.1023/a:1015765201129
https://doi.org/10.1023/a:1015765201129
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 27:1-21
Prednisolone (Pred) and sirolimus (SIR) are immunosuppressive compounds acting through different mechanisms with moderate synergism found in vitro. Both drugs are metabolized partly by CYP3A enzymes. After iv administration of placebo, Pred (5 mg/kg)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::986f528ac98ed90b6eed1f51390dbb17
https://doi.org/10.1023/a:1020626611479
https://doi.org/10.1023/a:1020626611479
Publikováno v:
Transplantation. 65:1203-1209
The immunologic response is one barrier to successful transplantation and T cell-mediated rejection is the major contributor to acute and chronic rejections leading to graft failure (1). Thus, to avoid or delay rejection, inimunosuppressive therapy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a61f0be731d58830694d8535c755657
https://doi.org/10.1097/00007890-199805150-00011
https://doi.org/10.1097/00007890-199805150-00011
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 26:619-648
Dose-dependent and repeated-dose effects of methylprednisolone (MPL) on down-regulation of glucocorticoid receptor messenger RNA (GR mRNA) and GR density, as well as tyrosine aminotransferase (TAT) mRNA and TAT induction by receptor/gene-mediated mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::944df701bc2f5965b93b25cb3559ceff
https://doi.org/10.1023/a:1020746822634
https://doi.org/10.1023/a:1020746822634
Publikováno v:
Immunopharmacology and Immunotoxicology. 17:335-345
Tacrolimus (FK 506) has synergistic immunosuppressive effects in combination with corticosteroids. A steroid dose-lowering effect can be explained partly by the inhibition by FK 506 of cytochrome P-450 IIIA, which metabolizes corticosteroids. We inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f48f7ff12e16fe3707cff620627124
https://doi.org/10.3109/08923979509019755
https://doi.org/10.3109/08923979509019755