Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nancy A. Nardone"'
Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning.
Autor:
Alex Gutteridge, J Michael Rukstalis, Daniel Ziemek, Mark Tié, Lin Ji, Rebeca Ramos-Zayas, Nancy A Nardone, Lisa D Norquay, Martin B Brenner, Kim Tang, John D McNeish, Rebecca K Rowntree
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56024 (2013)
We have used a previously unavailable model of pancreatic development, derived in vitro from human embryonic stem cells, to capture a time-course of gene, miRNA and histone modification levels in pancreatic endocrine cells. We investigated whether it
Externí odkaz:
https://doaj.org/article/ba50e4e5722448bd92405c4304f6ca70
Autor:
Melissa L. Gillaspy, Diane M. Hargrove, Mary E. Lame, Paul Da Silva Jardine, Dennis O. Scott, Catherine E. Trebino, Yingxin Zhang, Kimberly O. Cameron, Richard L. Elliott, Kelly A. Martin, Janice E. Chin, Elena E. Beretta, Swick Andrew Gordon, Jeffrey S. Dubins, Janet A. LaFlamme, Dexue Sun, Tristan S. Maurer, Nancy A. Nardone, Amit S. Kalgutkar, Jeremy A. Bartlett, Robert M. Oliver, Yue Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6797-6801
We describe the design, synthesis, and structure-activity relationships of triazolobenzodiazepinone CCK1 receptor agonists. Analogs in this series demonstrate potent agonist activity as measured by in vitro and in vivo assays for CCK1 agonism. Our ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeaaaf4e60123f7f9fd8e609d714c16d
https://doi.org/10.1016/j.bmcl.2010.08.115
https://doi.org/10.1016/j.bmcl.2010.08.115
Autor:
Thomas H. Reynolds, Ralph W. Stevenson, E. Michael Gibbs, Scott C. McCoid, Joseph T. Brozinick, Samuel W. Cushman, Diane M. Hargrove, Nancy A. Nardone
Publikováno v:
Diabetes. 50:593-600
We previously reported that overexpression of GLUT4 in lean, nondiabetic C57BL/KsJ- lepr db/+ ( db/+ ) mice resulted in improved glucose tolerance associated with increased basal and insulin-stimulated glucose transport in isolated skeletal muscle. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d02f52c96f088b1661cc016aea95428
https://doi.org/10.2337/diabetes.50.3.593
https://doi.org/10.2337/diabetes.50.3.593
Publikováno v:
Metabolism. 44:1231-1237
In vitro, truncated glucagon-like peptides [GLP-1(7-36)-amide and GLP-1(7-37)] increase insulin secretion in a glucose-dependent manner, and desensitization to the action of GLP-1(7-37) has been demonstrated acutely with high concentrations. The purp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94ed7847b8912684ae9ed5e79204906
https://doi.org/10.1016/0026-0495(95)90021-7
https://doi.org/10.1016/0026-0495(95)90021-7
Autor:
Nancy A. Nardone, J E Pessin, J F Russo, Diane M. Hargrove, R. K. Mcpherson, E M Gibbs, H A Stukenbrok, Anthony J. Milici, Judith L. Treadway, R W Stevenson
Publikováno v:
Journal of Biological Chemistry. 269:29956-29961
Human GLUT4 protein expression in muscle and adipose tissues of transgenic mice decreases plasma insulin and glucose levels and improves glucose tolerance compared with nontransgenic controls (Liu, M.-L., Gibbs, E. M., McCoid, S. C., Milici, A. J., S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf56a53d92a876557bd08d74bbb38f4b
https://doi.org/10.1016/s0021-9258(18)43974-9
https://doi.org/10.1016/s0021-9258(18)43974-9
Autor:
David H, Singleton, James G, Boyd, Nancy A, Nardone, Brett S, Robinson, Lydia C, Pan, John R, Hadcock, A Zane, Wenzel
Publikováno v:
Advances in experimental medicine and biology. 611
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2cf058a873dfec4effe93d2c6adb74d6
https://pubmed.ncbi.nlm.nih.gov/19400309
https://pubmed.ncbi.nlm.nih.gov/19400309
Autor:
John R. Hadcock, Nancy A. Nardone, A. Zane Wenzel, Lydia C. Pan, James G. Boyd, Brett S. Robinson, David H. Singleton
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387736563
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::159a8605baa3a27c1cdd2b1ff2e2045c
https://doi.org/10.1007/978-0-387-73657-0_242
https://doi.org/10.1007/978-0-387-73657-0_242
Autor:
Tristan S. Maurer, Kelly A. Martin, Robert F. Day, Jennifer Lafontaine, Diane M. Hargrove, John R. Hadcock, David A. Tess, Nancy A. Nardone, Paul DaSilva-Jardine, Joe Dibrino, Michael C. Linhares
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(18)
A novel series of heterocycle-based analogs were prepared and evaluated for their in vitro and in vivo biological activity as human beta(3)-adrenergic receptor (AR) agonists. Several analogs demonstrated potent agonist activity at the beta(3)-AR, fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d7c1ff8469672b55273cafe4fe8ed9
https://pubmed.ncbi.nlm.nih.gov/17632003
https://pubmed.ncbi.nlm.nih.gov/17632003
Autor:
Tristan S. Maurer, Diane M. Hargrove, John R. Hadcock, Paul DaSilva-Jardine, Robert L. Dow, Kelly A. Martin, Steven R. Schneider, David A. Tess, Nancy A. Nardone, Ernest S. Paight
Publikováno v:
ChemInform. 35
A series of sulfamide-based analogs related to L-796568 were prepared and evaluated for their biological activity at the human beta(3)-adrenergic receptor (AR). This modification allows for a significant reduction in molecular weight, while maintaini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d28a4532f9631c2b43b67a02c0b836
https://doi.org/10.1002/chin.200440139
https://doi.org/10.1002/chin.200440139
Autor:
Maria A. Vanvolkenburg, Diane M. Hargrove, Janice C. Parker, Kim M. Andrews, Nancy A. Nardone
Publikováno v:
Biochemical and biophysical research communications. 236(3)
The effects of selective inhibition of cyclic AMP phosphodiesterase type III on insulin and glucose levels during an oral glucose challenge were evaluated in obese, diabetic ob/ob mice and in lean, non-diabetic littermates using the selective inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3331f272a5e884184a9f5d18f19c66f
https://pubmed.ncbi.nlm.nih.gov/9245710
https://pubmed.ncbi.nlm.nih.gov/9245710