Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Nancy A. Hansen"'
Autor:
Meghan L. Rudd, Nancy F. Hansen, Xiaolu Zhang, Mary Ellen Urick, Suiyuan Zhang, Maria J. Merino, National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program, James C. Mullikin, Lawrence C. Brody, Daphne W. Bell
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Endometrioid endometrial carcinomas (EECs) are the most common histological subtype of uterine cancer. Late-stage disease is an adverse prognosticator for EEC. The purpose of this study was to analyze EEC exome mutation data to identify late-stage-sp
Externí odkaz:
https://doaj.org/article/aaed31c34d2b4dedb9f2db47d9827fa1
Autor:
Zhi Liu, Daniel Shriner, Nancy F Hansen, Charles N Rotimi, James C Mullikin, NISC Comparative Sequencing Program
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0232048 (2020)
Hypertension occurs at a higher rate in African Americans than in European Americans. Based on the assumption that causal variants are more frequently found on DNA segments inherited from the ancestral population with higher disease risk, we employed
Externí odkaz:
https://doaj.org/article/5148fe86c9f14437a04f753e6c72684b
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 9, Pp 2865-2873 (2018)
Understanding how genomic variation causes differences in observable phenotypes remains a major challenge in biology. It is difficult to trace the sequence of events originating from genomic variants to changes in transcriptional responses or protein
Externí odkaz:
https://doaj.org/article/45c5e4df60174612bea8e30a6aee9774
Autor:
Sergey Nurk, Sergey Koren, Arang Rhie, Mikko Rautiainen, Andrey V. Bzikadze, Alla Mikheenko, Mitchell R. Vollger, Nicolas Altemose, Lev Uralsky, Ariel Gershman, Sergey Aganezov, Savannah J. Hoyt, Mark Diekhans, Glennis A. Logsdon, Michael Alonge, Stylianos E. Antonarakis, Matthew Borchers, Gerard G. Bouffard, Shelise Y. Brooks, Gina V. Caldas, Nae-Chyun Chen, Haoyu Cheng, Chen-Shan Chin, William Chow, Leonardo G. de Lima, Philip C. Dishuck, Richard Durbin, Tatiana Dvorkina, Ian T. Fiddes, Giulio Formenti, Robert S. Fulton, Arkarachai Fungtammasan, Erik Garrison, Patrick G. S. Grady, Tina A. Graves-Lindsay, Ira M. Hall, Nancy F. Hansen, Gabrielle A. Hartley, Marina Haukness, Kerstin Howe, Michael W. Hunkapiller, Chirag Jain, Miten Jain, Erich D. Jarvis, Peter Kerpedjiev, Melanie Kirsche, Mikhail Kolmogorov, Jonas Korlach, Milinn Kremitzki, Heng Li, Valerie V. Maduro, Tobias Marschall, Ann M. McCartney, Jennifer McDaniel, Danny E. Miller, James C. Mullikin, Eugene W. Myers, Nathan D. Olson, Benedict Paten, Paul Peluso, Pavel A. Pevzner, David Porubsky, Tamara Potapova, Evgeny I. Rogaev, Jeffrey A. Rosenfeld, Steven L. Salzberg, Valerie A. Schneider, Fritz J. Sedlazeck, Kishwar Shafin, Colin J. Shew, Alaina Shumate, Ying Sims, Arian F. A. Smit, Daniela C. Soto, Ivan Sović, Jessica M. Storer, Aaron Streets, Beth A. Sullivan, Françoise Thibaud-Nissen, James Torrance, Justin Wagner, Brian P. Walenz, Aaron Wenger, Jonathan M. D. Wood, Chunlin Xiao, Stephanie M. Yan, Alice C. Young, Samantha Zarate, Urvashi Surti, Rajiv C. McCoy, Megan Y. Dennis, Ivan A. Alexandrov, Jennifer L. Gerton, Rachel J. O’Neill, Winston Timp, Justin M. Zook, Michael C. Schatz, Evan E. Eichler, Karen H. Miga, Adam M. Phillippy
Publikováno v:
Science (New York, N.Y.), vol 376, iss 6588
Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addressing the remaining 8% of the genome, the Telomere-to-Telomere (T2T) Con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a90349d97678f40cdb370a46304d2d
https://doi.org/10.1126/science.abj6987
https://doi.org/10.1126/science.abj6987
Autor:
Evan Biederstedt, Jeffrey C. Oliver, Nancy F. Hansen, Aarti Jajoo, Nathan Dunn, Andrew Olson, Ben Busby, Alexander T. Dilthey
Publikováno v:
F1000Research, Vol 7 (2018)
Genome graphs are emerging as an important novel approach to the analysis of high-throughput human sequencing data. By explicitly representing genetic variants and alternative haplotypes in a mappable data structure, they can enable the improved anal
Externí odkaz:
https://doaj.org/article/110ea799ddee4c799db9f6f7fcb20ed0
Autor:
Arang Rhie, Sergey Nurk, Monika Cechova, Savannah J. Hoyt, Dylan J. Taylor, Nicolas Altemose, Paul W. Hook, Sergey Koren, Mikko Rautiainen, Ivan A. Alexandrov, Jamie Allen, Mobin Asri, Andrey V. Bzikadze, Nae-Chyun Chen, Chen-Shan Chin, Mark Diekhans, Paul Flicek, Giulio Formenti, Arkarachai Fungtammasan, Carlos Garcia Giron, Erik Garrison, Ariel Gershman, Jennifer Gerton, Patrick G.S. Grady, Andrea Guarracino, Leanne Haggerty, Reza Halabian, Nancy F. Hansen, Robert Harris, Gabrielle A. Hartley, William T. Harvey, Marina Haukness, Jakob Heinz, Thibaut Hourlier, Robert M. Hubley, Sarah E. Hunt, Stephen Hwang, Miten Jain, Rupesh K. Kesharwani, Alexandra P. Lewis, Heng Li, Glennis A. Logsdon, Julian K. Lucas, Wojciech Makalowski, Christopher Markovic, Fergal J. Martin, Ann M. Mc Cartney, Rajiv C. McCoy, Jennifer McDaniel, Brandy M. McNulty, Paul Medvedev, Alla Mikheenko, Katherine M. Munson, Terence D. Murphy, Hugh E. Olsen, Nathan D. Olson, Luis F. Paulin, David Porubsky, Tamara Potapova, Fedor Ryabov, Steven L. Salzberg, Michael E.G. Sauria, Fritz J. Sedlazeck, Kishwar Shafin, Valery A. Shepelev, Alaina Shumate, Jessica M. Storer, Likhitha Surapaneni, Angela M. Taravella Oill, Françoise Thibaud-Nissen, Winston Timp, Marta Tomaszkiewicz, Mitchell R. Vollger, Brian P. Walenz, Allison C. Watwood, Matthias H. Weissensteiner, Aaron M. Wenger, Melissa A. Wilson, Samantha Zarate, Yiming Zhu, Justin M. Zook, Evan E. Eichler, Rachel O’Neill, Michael C. Schatz, Karen H. Miga, Kateryna D. Makova, Adam M. Phillippy
The human Y chromosome has been notoriously difficult to sequence and assemble because of its complex repeat structure including long palindromes, tandem repeats, and segmental duplications. As a result, more than half of the Y chromosome is missing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38b477c2daccca72d1302cd2225927d
https://doi.org/10.1101/2022.12.01.518724
https://doi.org/10.1101/2022.12.01.518724
Publikováno v:
PLoS Genetics, Vol 13, Iss 12, p e1007098 (2017)
Why do some individuals need more sleep than others? Forward mutagenesis screens in flies using engineered mutations have established a clear genetic component to sleep duration, revealing mutants that convey very long or short sleep. Whether such ex
Externí odkaz:
https://doaj.org/article/6a97b450e9264896bf406992dd2cdb97
Autor:
Sergey Aganezov, Stephanie M. Yan, Daniela C. Soto, Melanie Kirsche, Samantha Zarate, Pavel Avdeyev, Dylan J. Taylor, Kishwar Shafin, Alaina Shumate, Chunlin Xiao, Justin Wagner, Jennifer McDaniel, Nathan D. Olson, Michael E. G. Sauria, Mitchell R. Vollger, Arang Rhie, Melissa Meredith, Skylar Martin, Joyce Lee, Sergey Koren, Jeffrey A. Rosenfeld, Benedict Paten, Ryan Layer, Chen-Shan Chin, Fritz J. Sedlazeck, Nancy F. Hansen, Danny E. Miller, Adam M. Phillippy, Karen H. Miga, Rajiv C. McCoy, Megan Y. Dennis, Justin M. Zook, Michael C. Schatz
Publikováno v:
Science
Science (New York, N.Y.), vol 376, iss 6588
Science (New York, N.Y.), vol 376, iss 6588
Compared to its predecessors, the Telomere-to-Telomere CHM13 genome adds nearly 200 million base pairs of sequence, corrects thousands of structural errors, and unlocks the most complex regions of the human genome for clinical and functional study. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5beca7b37f397ee4479667b1452da27
https://europepmc.org/articles/PMC9336181/
https://europepmc.org/articles/PMC9336181/
Autor:
Chen-Shan Chin, Stephanie M Yan, Skylar Martin, Jeffrey A. Rosenfeld, Alaina Shumate, Arang Rhie, Daniela C. Soto, Sergey Koren, Melanie Kirsche, Joyce V. Lee, Chunlin Xiao, Megan Y. Dennis, Dylan J. Taylor, Ryan M. Layer, Mitchell R. Vollger, Justin M. Zook, Adam M. Phillippy, Melissa M. Meredith, Karen H. Miga, Pavel Avdeyev, Nancy F. Hansen, Benedict Paten, Kishwar Shafin, Danny E. Miller, Jennifer McDaniel, Sergey Aganezov, Rajiv C. McCoy, Michael E.G. Sauria, Nathan D. Olson, Justin Wagner, Samantha Zarate, Fritz J. Sedlazeck, Michael C. Schatz
Compared to its predecessors, the Telomere-to-Telomere CHM13 genome adds nearly 200 Mbp of sequence, corrects thousands of structural errors, and unlocks the most complex regions of the human genome to clinical and functional study. Here we demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::350c95a5c44ac46cc00470e6f533b832
https://doi.org/10.1101/2021.07.12.452063
https://doi.org/10.1101/2021.07.12.452063
Autor:
Amy R Bentley, Guanjie Chen, Daniel Shriner, Ayo P Doumatey, Jie Zhou, Hanxia Huang, James C Mullikin, Robert W Blakesley, Nancy F Hansen, Gerard G Bouffard, Praveen F Cherukuri, Baishali Maskeri, Alice C Young, Adebowale Adeyemo, Charles N Rotimi
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004190 (2014)
Although a considerable proportion of serum lipids loci identified in European ancestry individuals (EA) replicate in African Americans (AA), interethnic differences in the distribution of serum lipids suggest that some genetic determinants differ by
Externí odkaz:
https://doaj.org/article/a6ff9c59fd2b4be3a0fefce070b59727