Zobrazeno 1 - 10
of 936
pro vyhledávání: '"Nancy A. Cox"'
Autor:
Yash Pershad, Taralynn Mack, Hannah Poisner, Yasminka A. Jakubek, Adrienne M. Stilp, Braxton D. Mitchell, Joshua P. Lewis, Eric Boerwinkle, Ruth J. F. Loos, Nathalie Chami, Zhe Wang, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Ali Shojaie, Edwin K. Silverman, Michael H. Cho, Jeong H. Yun, Dawn DeMeo, Daniel Levy, Andrew D. Johnson, Rasika A. Mathias, Margaret A. Taub, Donna Arnett, Kari E. North, Laura M. Raffield, April P. Carson, Margaret F. Doyle, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Nancy J. Cox, Dan M. Roden, Nora Franceschini, Pinkal Desai, Alex P. Reiner, Paul L. Auer, Paul A. Scheet, Siddhartha Jaiswal, Joshua S. Weinstock, Alexander G. Bick
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger st
Externí odkaz:
https://doaj.org/article/1250c0a2d37c41cbad1c671a34d1b82b
Autor:
Jonathan D. Mosley, John P. Shelley, Alyson L. Dickson, Jacy Zanussi, Laura L. Daniel, Neil S. Zheng, Lisa Bastarache, Wei-Qi Wei, Mingjian Shi, Gail P. Jarvik, Elisabeth A. Rosenthal, Atlas Khan, Alborz Sherafati, Iftikhar J. Kullo, Theresa L. Walunas, Joseph Glessner, Hakon Hakonarson, Nancy J. Cox, Dan M. Roden, Stephan G. Frangakis, Brett Vanderwerff, C. Michael Stein, Sara L. Van Driest, Scott C. Borinstein, Xiao-Ou Shu, Matthew Zawistowski, Cecilia P. Chung, Vivian K. Kawai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical consequences of a genetic predisposit
Externí odkaz:
https://doaj.org/article/aac9cb1b2aa64c909fbdd66e307ed326
Autor:
David Carmona-Berrio, Isabel Adarve-Rengifo, Andrea G. Marshall, Zer Vue, Duane D. Hall, Tyne W. Miller-Fleming, Ky’Era V. Actkins, Heather K. Beasley, Paula M. Almonacid, Pierina Barturen-Larrea, Quinn S. Wells, Marcos G. Lopez, Edgar Garza-Lopez, Dao-Fu Dai, Jianqiang Shao, Kit Neikirk, Frederic T. Billings, IV, John A. Curci, Nancy J. Cox, Vivian Gama, Antentor Hinton, Jr., Jose A. Gomez
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110436- (2024)
Summary: Abdominal and thoracic aortic aneurysms (AAAs, TAAs) remain a major cause of deaths worldwide, in part due to the lack of reliable prognostic markers or early warning signs. Sox6 has been found to regulate renin controlling blood pressure. W
Externí odkaz:
https://doaj.org/article/10fbddafdd5e4e57aba0f987d45fef4e
Autor:
Quan Sun, Bryce T. Rowland, Jiawen Chen, Anna V. Mikhaylova, Christy Avery, Ulrike Peters, Jessica Lundin, Tara Matise, Steve Buyske, Ran Tao, Rasika A. Mathias, Alexander P. Reiner, Paul L. Auer, Nancy J. Cox, Charles Kooperberg, Timothy A. Thornton, Laura M. Raffield, Yun Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without accommodating recently-admixed individuals with mosaic continental ancestry backg
Externí odkaz:
https://doaj.org/article/fe84353ad55c46c3a18b767c25d45ba3
Autor:
Lan Jiang, Srushti Gangireddy, Alyson L. Dickson, Yi Xin, Chao Yan, Vivian Kawai, Nancy J. Cox, MacRae F. Linton, Wei-Qi Wei, C. Michael Stein, QiPing Feng
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100569- (2024)
Hypertriglyceridemia (HTG) is a common cardiovascular risk factor characterized by elevated triglyceride (TG) levels. Researchers have assessed the genetic factors that influence HTG in studies focused predominantly on individuals of European ancestr
Externí odkaz:
https://doaj.org/article/da16de995003474fb80d5f0f18e3d4e6
Autor:
Kathleen D. Valverde, Tiffiney R. Hartman, Sara L. Reichert, Robin L. Bennett, Martha Dudek, Debra Duquette, Daniel Riconda, Nancy J. Cox, Gail P. Jarvik, Sarah H. Elsea, Elizabeth M. McNally, Kim C. Worley, Daniel J. Rader
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101854- (2024)
Externí odkaz:
https://doaj.org/article/5d574fd0846b455ba3d0d5205910250f
Autor:
Jiayao Fan, Yuan Zhou, Ran Meng, Jinsong Tang, Jiahao Zhu, Melinda C. Aldrich, Nancy J. Cox, Yimin Zhu, Yingjun Li, Dan Zhou
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Considerable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microbiota-gut–brain axis also in turn hinted at a possible contribution of the gut microbiota to smoking. Howev
Externí odkaz:
https://doaj.org/article/adf87b38f5ac44e780702eb87d6ac51a
Autor:
Lan Jiang, Ge Liu, Annette Oeser, Andrea Ihegword, Alyson L Dickson, Laura L Daniel, Adriana M Hung, Nancy J Cox, Cecilia P Chung, Wei-Qi Wei, C Michael Stein, Qiping Feng
Publikováno v:
eLife, Vol 12 (2023)
Background: Two risk variants in the apolipoprotein L1 gene (APOL1) have been associated with increased susceptibility to sepsis in Black patients. However, it remains unclear whether APOL1 high-risk genotypes are associated with occurrence of either
Externí odkaz:
https://doaj.org/article/3baa0f4a81db461eb55066a00231d9f0
Autor:
Jibril B. Hirbo, Francesca Pasutto, Eric R. Gamazon, Patrick Evans, Priyanka Pawar, Daniel Berner, Julia Sealock, Ran Tao, Peter S. Straub, Anuar I. Konkashbaev, Max A. Breyer, Ursula Schlötzer-Schrehardt, André Reis, Milam A. Brantley, Chiea C. Khor, Karen M. Joos, Nancy J. Cox
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Background Exfoliation syndrome (XFS) is an age-related systemic disorder characterized by excessive production and progressive accumulation of abnormal extracellular material, with pathognomonic ocular manifestations. It is the most common
Externí odkaz:
https://doaj.org/article/82d3f177781d42b589d0669591c932ac
Autor:
Mohammad Shahbazi, Xindi Zhang, Paul C. Dinh, Victoria A. Sanchez, Matthew R. Trendowski, Megan M. Shuey, Tessa Nguyen, Regeneron Genetics Center, Darren R. Feldman, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Neil E. Martin, Lawrence H. Einhorn, Nancy J. Cox, Robert D. Frisina, Lois B. Travis, Mary Eileen Dolan
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 2999-3012 (2023)
Abstract Purpose Deficits in speech understanding constitute one of the most severe consequences of hearing loss. Here we investigate the clinical and genetic risk factors for symmetric deterioration of speech recognition thresholds (SRT) among cance
Externí odkaz:
https://doaj.org/article/aedaa37449a4452f9310279b835a3e66