Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Nancy A Benkusky"'
Publikováno v:
JBMR Plus, Vol 5, Iss 1, Pp n/a-n/a (2021)
ABSTRACT Our recent genomic studies identified a complex kidney‐specific enhancer module located within the introns of adjacent Mettl1 (M1) and Mettl21b (M21) genes that mediate basal and PTH induction of Cyp27b1, as well as suppression by FGF23 an
Externí odkaz:
https://doaj.org/article/6d2c1b4199924733849a64b5fe3c73a7
Autor:
Ryan S MacLeod, Mark B Meyer, Jinhu Xiong, Keisha M Cawley, Yu Liu, Melda Onal, Nancy A Benkusky, Jeff D Thostenson, J Wesley Pike, Charles A O'Brien
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250974 (2021)
The cytokine RANKL is essential for osteoclast formation during physiological and pathological bone resorption. RANKL also contributes to lymphocyte production, development of lymph nodes and mammary glands, as well as other biological activities. Tr
Externí odkaz:
https://doaj.org/article/4047ea3d5756425eb485380cdefc3d75
Autor:
Sung-Hee Yoon, Mark B. Meyer, Carlos Arevalo, Murat Tekguc, Chengcheng Zhang, Jialiang S. Wang, Christian D. Castro Andrade, Katelyn Strauss, Tadatoshi Sato, Nancy A. Benkusky, Seong Min Lee, Rebecca Berdeaux, Marc Foretz, Thomas B. Sundberg, Ramnik J. Xavier, Charles H. Adelmann, Daniel J. Brooks, Anthony Anselmo, Ruslan I. Sadreyev, Ivy A. Rosales, David E. Fisher, Navin Gupta, Ryuji Morizane, Anna Greka, J. Wesley Pike, Michael Mannstadt, Marc N. Wein
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs) orchestrated
Externí odkaz:
https://doaj.org/article/807eb29db7bc4680b7215fddd31857a3
Autor:
Mark B. Meyer, Nancy A. Benkusky, Seong Min Lee, Sung-Hee Yoon, Michael Mannstadt, Marc N. Wein, J. Wesley Pike
Publikováno v:
Journal of Biological Chemistry. 298:102559
Vitamin D metabolism centers on kidney regulation of Cyp27b1 by mineralotropic hormones, including induction by parathyroid hormone (PTH), suppression by fibroblast growth factor 23 (FGF23) and 1,25-dihydroxyvitamin D
Publikováno v:
Endocrinology
Fibroblast growth factor 23 (FGF23) is a bone-derived hormone involved in the control of phosphate (P) homeostasis and vitamin D metabolism. Despite advances, however, molecular details of this gene’s regulation remain uncertain. In this report, we
Autor:
Martin Kaufmann, Seong Min Lee, Robert R. Redfield, Mark B. Meyer, Nancy A. Benkusky, J. Wesley Pike, Glenville Jones
Publikováno v:
J Biol Chem
Vitamin D(3) is terminally bioactivated in the kidney to 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via cytochrome P450 family 27 subfamily B member 1 (CYP27B1), whose gene is regulated by parathyroid hormone (PTH), fibroblast growth factor 23 (F
Publikováno v:
JBMR Plus, Vol 5, Iss 1, Pp n/a-n/a (2021)
JBMR Plus
JBMR Plus
Our recent genomic studies identified a complex kidney‐specific enhancer module located within the introns of adjacent Mettl1 (M1) and Mettl21b (M21) genes that mediate basal and PTH induction of Cyp27b1, as well as suppression by FGF23 and 1,25‐
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 177:36-45
The vitamin D receptor (VDR) mediates the pleiotropic biological actions of 1,25-dihydroxyvitamin D(3)(1,25(OH)(2)D(3)). These actions include orchestration of mineral homeostasis which is coordinated by the kidney, intestine, bone and parathyroid gl
Autor:
Jeff D. Thostenson, Alex H. Carlson, Seong Min Lee, Mark B. Meyer, Melda Onal, Nancy A. Benkusky, J. Wesley Pike
Publikováno v:
JBMR Plus. 2:31-46
Fibroblast growth factor 23 (FGF23) production is regulated by both calciotropic hormones and inflammation. Consistent with this, elevated FGF23 levels are associated with inflammatory markers as well as parathyroid hormone (PTH) in various disease s