Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Nancy, Ratner"'
Autor:
Siddhi N. Paudel, Brian J. Hutzen, Katherine E. Miller, Elizabeth A. R. Garfinkle, Chun-Yu Chen, Pin-Yi Wang, Andrea M. Glaspell, Mark A. Currier, Emily M. Ringwalt, Louis Boon, Elaine R. Mardis, Mitchell S. Cairo, Nancy Ratner, Rebecca D. Dodd, Kevin A. Cassady, Timothy P. Cripe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/aea62abb85594bdd81547a1e4aff9626
Autor:
Jennifer Patritti-Cram, Eric P. Rahrmann, Tilat A. Rizvi, Katherine C. Scheffer, Timothy N. Phoenix, David A. Largaespada, Nancy Ratner
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110294- (2024)
Summary: The blood-nerve-barrier (BNB) that regulates peripheral nerve homeostasis is formed by endoneurial capillaries and perineurial cells surrounding the Schwann cell (SC)-rich endoneurium. Barrier dysfunction is common in human tumorigenesis, in
Externí odkaz:
https://doaj.org/article/b2e4f7d4622f4f9db1bac7a662c21301
Autor:
Siddhi N. Paudel, Brian J. Hutzen, Katherine E. Miller, Elizabeth A. R. Garfinkle, Chun-Yu Chen, Pin-Yi Wang, Andrea M. Glaspell, Mark A. Currier, Emily M. Ringwalt, Louis Boon, Elaine R. Mardis, Mitchell S. Cairo, Nancy Ratner, Rebecca D. Dodd, Kevin A. Cassady, Timothy P. Cripe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionMalignant peripheral nerve sheath tumors (MPNST) pose a significant therapeutic challenge due to high recurrence rates after surgical resection and a largely ineffective response to traditional chemotherapy. An alternative treatment strat
Externí odkaz:
https://doaj.org/article/30c6602860ac408d8659f1b13326bd9a
Autor:
Miriam Magallón-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernández, Gerard Requena, Inma Rosas, Helena Mazuelas, Itziar Uriarte-Arrazola, Alex Negro, Tereza Lausová, Elisabeth Castellanos, Ignacio Blanco, George DeVries, Hiroyuki Kawashima, Eric Legius, Hilde Brems, Viktor Mautner, Lan Kluwe, Nancy Ratner, Margaret Wallace, Juana Fernández-Rodriguez, Conxi Lázaro, Jonathan A. Fletcher, David Reuss, Meritxell Carrió, Bernat Gel, Eduard Serra
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106096- (2023)
Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas of the peripheral nervous system that develop either sporadically or in the context of neurofibromatosis type 1 (NF1). MPNST diagnosis can be challenging and treatmen
Externí odkaz:
https://doaj.org/article/47d61282e05c49bc9cb540ffd4fb4a24
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281876 (2023)
Neurofibromatosis Type 2 is an inherited disease characterized by Schwann cell tumors of cranial and peripheral nerves. The NF2 gene encodes Merlin, a member of the ERM family consisting of an N-terminal FERM domain, a central α-helical region, and
Externí odkaz:
https://doaj.org/article/f999f2a55ba541cbb2dca0312033a332
Autor:
Leah J. Kershner, Kwangmin Choi, Jianqiang Wu, Xiyuan Zhang, Melissa Perrino, Nathan Salomonis, Jack F. Shern, Nancy Ratner
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis 1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas, benign tumors driven by NF1 loss in Schwann cells (SCs). By comparing n
Externí odkaz:
https://doaj.org/article/50276e58914543fb9bda0e1f1e2739c2
Autor:
Jennifer Patritti Cram, Jianqiang Wu, Robert A Coover, Tilat A Rizvi, Katherine E Chaney, Ramya Ravindran, Jose A Cancelas, Robert J Spinner, Nancy Ratner
Publikováno v:
eLife, Vol 11 (2022)
Neurofibromatosis type 1 (NF1) is characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. We identified the G-protein-coupled receptor (GPCR) P2ry1
Externí odkaz:
https://doaj.org/article/cb19eefec69648a0af42e1875c368a55
Autor:
Alexander C. Doherty, David A. Huddleston, Paul S. Horn, Nancy Ratner, Brittany N. Simpson, Elizabeth K. Schorry, Lindsey Aschbacher-Smith, Carlos E. Prada, Donald L. Gilbert
Publikováno v:
Pediatric Neurology. 143:34-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a8fb8cabcb1c663df8d5ca472b3351c
https://doi.org/10.1016/j.pediatrneurol.2023.02.014
https://doi.org/10.1016/j.pediatrneurol.2023.02.014
Autor:
Kwangmin Choi, Nancy Ratner
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-7 (2019)
Abstract Background The use of microarrays and RNA-seq technologies is ubiquitous for transcriptome analyses in modern biology. With proper analysis tools, the differential gene expression analysis process can be significantly accelerated. Many open-
Externí odkaz:
https://doaj.org/article/b90c01e4d2e84debae23b11965acb796
Autor:
Youjin Na, Ashley Hall, Yanan Yu, Liang Hu, Kwangmin Choi, Jake A. Burgard, Sara Szabo, Gang Huang, Nancy Ratner, Jianqiang Wu
Publikováno v:
Oncogene
Neurofibromatosis type 1 (NF1) patients are predisposed to develop plexiform neurofibromas (PNFs). Three endoplasmic reticulum (ER) stress response pathways restore cellular homeostasis. The unfolded protein response (UPR) sensors contribute to tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2615e8ed010ab41e6ebba61f8262c57f
https://doi.org/10.1038/s41388-023-02620-x
https://doi.org/10.1038/s41388-023-02620-x