Výsledky vyhledávání - "Nancy, Cauwenberghs"

Inhibition of Platelet Glycoprotein Ib, Glycoprotein IIb/IIIa, or Both by Monoclonal Antibodies Prevents Arterial Thrombosis in Baboons

Autor: Nancy Cauwenberghs, Hans Deckmyn, Muriel Meiring, Harry F. Kotze, Dongmei Wu

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 22:323-328

The antithrombotic efficacy of the monoclonal antibodies 6B4-Fab and MA-16N7C2 against platelet glycoprotein (GP) Ib and GP IIb/IIIa, respectively, on acute platelet-mediated thrombosis was evaluated in a baboon model of femoral artery stenosis, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26b7ce3dc7837b84d0bdb436525726e
https://doi.org/10.1161/hq0202.102321

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A Reliable von Willebrand Factor: Ristocetin Cofactor Enzyme-Linked Immunosorbent Assay to Differentiate between Type 1 and Type 2 von Willebrand Disease

Autor: Griet Vandecasteele, Nancy Cauwenberghs, Karen Vanhoorelbeke, Hans Deckmyn, S Vauterin

Publikováno v: Seminars in Thrombosis and Hemostasis. 28:161-166

von Willebrand disease (vWD) is the most common hereditary bleeding disorder due to either a qualitative or a quantitative defect in von Willebrand factor (vWF). vWF is a multimeric plasma protein that plays an important role in (1) primary hemostasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeb43121cef005ead51b1905c55c41e
https://doi.org/10.1055/s-2002-27818

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Antithrombotic Effect of Platelet Glycoprotein Ib–Blocking Monoclonal Antibody Fab Fragments in Nonhuman Primates

Autor: Harry F. Kotze, Levente Novák, Seb Lamprecht, J. P. Roodt, S Vauterin, Muriel Meiring, Jolan Harsfalvi, Hans Deckmyn, Nancy Cauwenberghs, Veronika van Wyk

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 20:1347-1353

Abstract —Platelet adhesion in arterial blood flow is mainly supported by the platelet receptor glycoprotein (GP) Ib, which interacts with von Willebrand factor (vWF) that is bound to collagen at the site of vessel wall injury. Antibody 6B4 is a mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f8774056246a5cba742ec59cafaeaa
https://doi.org/10.1161/01.atv.20.5.1347

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Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons

Autor: Dongmei Wu, Harry F. Kotze, Nancy Cauwenberghs, Karen Vanhoorelbeke, H Depraetere, Muriel Meiring, Hans Deckmyn

Publikováno v: Blood. 99(10)

The interaction between collagen, von Willebrand factor (VWF), and glycoprotein Ib is the first step in hemostasis and thrombosis especially under high shear conditions. We studied the inhibition of the VWF-collagen interaction by using an antihuman

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb27cb0bdbb78c3ce83788513b58abaa
https://pubmed.ncbi.nlm.nih.gov/12509386

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Fc-receptor Dependent Platelet Aggregation Induced by Monoclonal Antibodies against Platelet Glycoprotein Ib or von Willebrand Factor

Autor: Nancy Cauwenberghs, Agotha Schlammadinger, Hans Deckmyn, Susan Cooper, Gretel Descheemaeker, István Tornai, S Vauterin

Publikováno v: Europe PubMed Central

SummaryIn this paper we describe two pathways leading to platelet activation by crosslinking glycoprotein (GP) Ib to the platelet Fc-receptor (FcγRII). First the monoclonal antibody (MoAb) 9C8, raised against human platelet GPIbα, dose-dependently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ab9873580e8242c3b310516ba6376c

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Characterization of murine anti-glycoprotein Ib monoclonal antibodies that differentiate between shear-induced and ristocetin/botrocetin-induced glycoprotein Ib-von Willebrand factor interaction

Autor: Dominique Baruch, Nancy Cauwenberghs, Nadine Ajzenberg, S Vauterin, Hans Deckmyn, Paul Declerck, Marc Hoylaerts

Publikováno v: ResearcherID
Europe PubMed Central

Platelet adhesion to vascular subendothelium under conditions of high shear stress is mediated by the platelet glycoprotein (GP) Ib-von Willebrand Factor (vWF) interaction. The aim of this study was to characterize the murine monoclonal antibodies (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515ee248fe449249cee0d90ed34a8150
https://pubmed.ncbi.nlm.nih.gov/11014964

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Acquired Bernard-Soulier syndrome: a case with necrotizing vasculitis and thrombosis

Autor: Zoltán Boda, Nancy Cauwenberghs, Attila Juhász, Hans Deckmyn, Jolan Harsfalvi, István Tornai, Ágota Schlammadinger

Publikováno v: Europe PubMed Central

We describe a patient with positive antinuclear antibodies, polyclonal gammopathy and high level of circulating immunocomplexes, resulting in vascular purpura. In addition, the patient had a slightly prolonged bleeding time and an isolated defect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad0da7a27473a1a5ccef2f5a991e15a
https://pubmed.ncbi.nlm.nih.gov/10702705

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A Platelet-Activating Antiglycoprotein Ib Monoclonal Antibody

Autor: Karen Vanhoorelbeke, Nancy Cauwenberghs, Hans Deckmyn

Publikováno v: Europe PubMed Central

To the Editor : In the March 1 issue, Yanabu et al[1][1] reported on a platelet-activating antiglycoprotein Ib monoclonal antibody (MoAb) NNKY5-5. The intact antibody, but not Fab-fragments, caused activation, and (Fab′)2 -fragments could not be pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0d8716dc5232474d4cf0dc8540f5e6
https://doi.org/10.1182/blood.v90.9.3807

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