Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Nancy, Boeckx"'
Autor:
Quentin Van Thillo, Jolien De Bie, Janith A. Seneviratne, Sofie Demeyer, Sofia Omari, Anushree Balachandran, Vicki Zhai, Wai L. Tam, Bram Sweron, Ellen Geerdens, Olga Gielen, Sarah Provost, Heidi Segers, Nancy Boeckx, Glenn M. Marshall, Belamy B. Cheung, Kiyotaka Isobe, Itaru Kato, Junko Takita, Timothy G. Amos, Ira W. Deveson, Hannah McCalmont, Richard B. Lock, Ethan P. Oxley, Maximilian M. Garwood, Ross A. Dickins, Anne Uyttebroeck, Daniel R. Carter, Jan Cools, Charles E. de Bock
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic
Externí odkaz:
https://doaj.org/article/097bfb27edca4477bb37a09172ff1f71
Autor:
Inge Govaerts, Cristina Prieto, Charlien Vandersmissen, Olga Gielen, Kris Jacobs, Sarah Provost, David Nittner, Johan Maertens, Nancy Boeckx, Kim De Keersmaecker, Heidi Segers, Jan Cools
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background T cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10–15% of childhood and 20–25% of adult ALL cases. Over 70% of T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway and ar
Externí odkaz:
https://doaj.org/article/bb40113fbbf041209361b8411e7b5c92
Autor:
Sarah Meyers, Llucia Alberti-Servera, Olga Gielen, Margot Erard, Toon Swings, Jolien De Bie, Lucienne Michaux, Barbara Dewaele, Nancy Boeckx, Anne Uyttebroeck, Kim De Keersmaecker, Johan Maertens, Heidi Segers, Jan Cools, Sofie Demeyer
Publikováno v:
HemaSphere, Vol 6, Iss 4, p e700 (2022)
Acute lymphoblastic leukemia (ALL) is characterized by the presence of chromosomal changes, including numerical changes, translocations, and deletions, which are often associated with additional single-nucleotide mutations. In this study, we used sin
Externí odkaz:
https://doaj.org/article/e780cd405cf54cd9a5f9fb1d197b4b0f
Autor:
Frederik Staels, Albrecht Betrains, F. J. Sherida H. Woei-A-Jin, Nancy Boeckx, Marielle Beckers, An Bervoets, Mathijs Willemsen, Barbara Neerinckx, Stephanie Humblet-Baron, Daniel Engelbert Blockmans, Steven Vanderschueren, Rik Schrijvers
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Recently, a novel disorder coined VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome was identified in patients with adult-onset inflammatory syndromes, often accompanied by myelodysplastic syndrome1. All patients had myeloid l
Externí odkaz:
https://doaj.org/article/64401fc2c3e04431b1fa037d312dd532
Autor:
Laura Yissel Rengifo, Sanne Smits, Lieselot Buedts, Michel Delforge, Luc Dehaspe, Thomas Tousseyn, Nancy Boeckx, Stefan Lehnert, Lucienne Michaux, Joris Robert Vermeesch, Peter Vandenberghe, Barbara Dewaele
Publikováno v:
Cancer Treatment and Research Communications, Vol 28, Iss , Pp 100380- (2021)
Multiple myeloma (MM), is a heterogeneous disease in which chromosomal abnormalities are important for prognostic risk stratification. Cytogenetic profiling with FISH on plasma cells from bone marrow samples (BM-PCs) is the current gold standard, but
Externí odkaz:
https://doaj.org/article/85c27e840f814546b405842cb93ef777
Autor:
Delphine Verbeke, Olga Gielen, Kris Jacobs, Nancy Boeckx, Kim De Keersmaecker, Johan Maertens, Anne Uyttebroeck, Heidi Segers, Jan Cools
Publikováno v:
HemaSphere, Vol 3, Iss 6, p e310 (2019)
Externí odkaz:
https://doaj.org/article/ac615e4f316e4ff88f91e9c5df9bf080
Autor:
Mathijs Willemsen, John S. Barber, Erika Van Nieuwenhove, Frederik Staels, Margaux Gerbaux, Julika Neumann, Teresa Prezzemolo, Emanuela Pasciuto, Vasiliki Lagou, Nancy Boeckx, Jessica Filtjens, Amber De Visscher, Patrick Matthys, Rik Schrijvers, Thomas Tousseyn, Mark O’Driscoll, Giorgia Bucciol, Susan Schlenner, Isabelle Meyts, Stephanie Humblet-Baron, Adrian Liston
BACKGROUND: Severe congenital neutropenia presents with recurrent infections early in life as a result of arrested granulopoiesis. Multiple genetic defects are known to block granulocyte differentiation; however, a genetic cause remains unknown in ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b6b05840aac2c6efbcbe0bb25a5d87
https://lirias.kuleuven.be/handle/20.500.12942/715773
https://lirias.kuleuven.be/handle/20.500.12942/715773
Autor:
Gaël Vermeersch, Lies Laenen, Géraldine Lens, Kim C. M. van der Elst, Dietmar Rudolf Thal, Sander Jentjens, Philippe Demaerel, Tine Van Nieuwenhuyse, Elke Wollants, Nancy Boeckx, Nicolas Verhaert, Benedicte Dubois, Frank J. M. Kuppeveld, F. J. Sherida H. Woei‐A‐Jin
Publikováno v:
European Journal of Neurology. 29:3117-3123
Enterovirus infections pose a serious threat for patients with humoral deficiencies and may be lethal, whilst the efficacy of proposed treatment options such as corticosteroids, intravenous immunoglobulins and fluoxetine remains debated.Viral clearan
Autor:
Jan Cools, Heidi Segers, Johan Maertens, Kim De Keersmaecker, Nancy Boeckx, Anne Uyttebroeck, Bronte Manouk Verhoeven, Nicole Mentens, Kris Jacobs, Olga Gielen, Jolien De Bie, Charles E. de Bock, Cristina Prieto, Sofie Demeyer, Delphine Verbeke
Suppl. figure 2: PDX samples have different basal NR3C1 expression levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89430e177458d0fad80d0548bb3338b3
https://doi.org/10.1158/1078-0432.22476440
https://doi.org/10.1158/1078-0432.22476440
Autor:
Jan Cools, Heidi Segers, Johan Maertens, Kim De Keersmaecker, Nancy Boeckx, Anne Uyttebroeck, Bronte Manouk Verhoeven, Nicole Mentens, Kris Jacobs, Olga Gielen, Jolien De Bie, Charles E. de Bock, Cristina Prieto, Sofie Demeyer, Delphine Verbeke
Purpose:KPT-8602 (Eltanexor) is a second-generation exportin-1 (XPO1) inhibitor with potent activity against acute lymphoblastic leukemia (ALL) in preclinical models and with minimal effects on normal cells. In this study, we evaluated whether KPT-86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088e57b5c1790041efefcae1a56f90f2
https://doi.org/10.1158/1078-0432.c.6529397.v1
https://doi.org/10.1158/1078-0432.c.6529397.v1