Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nanco R. Hefting"'
Autor:
John Allanson, Deborah A. Smith, Richard Peck, Nanco R. Hefting, Jan J. van Lier, Emma J. Seaber, Frans A. E. Sollie, Johan Wemer, Jan H. G. Jonkman
Publikováno v:
British Journal of Clinical Pharmacology. 46:433-439
Aims Zolmitriptan (Zomig (formerly 311C90)) is a novel 5-HT1B/1D receptor agonist developed for the acute oral treatment of migraine. A highly sensitive LCMS-MS assay has been developed which allows quantification of plasma concentrations of zolmitri
Autor:
Nanco R. Hefting, Dirk K. F. Meijer, Coenraad F. Lerk, Henderik W. Frijlink, Anko C. Eissens, Klaas Poelstra
Publikováno v:
Pharmaceutical Research. :9-16
The inclusion complex formation of intravenously administered hydroxypropyl-beta-cyclodextrin and beta-cyclodextrin with endogenous lipids was studied. We tested the hypothesis that complex formation of endogenous cholesterol with cyclodextrins in th
Autor:
Henderik W. Frijlink, Roelof Oosting, Nanco R. Hefting, Dirk K. F. Meijer, Coenraad F. Lerk, Jan Visser
Publikováno v:
Pharmaceutical Research. :1248-1252
Hydroxypropyl-beta-cyclodextrin was analyzed by HPLC using postcolumn complexation with phenolphthalein and negative colorimetric detection, with a detection limit of 20 micrograms/ml. The pharmacokinetics of beta-cyclodextrin and of hydroxypropyl-be