Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Nancie M. Archin"'
Autor:
Lijun Ling, Chandrav De, Rae Ann Spagnuolo, Nurjahan Begum, Shane D. Falcinelli, Nancie M. Archin, Martina Kovarova, Guido Silvestri, Angela Wahl, David M. Margolis, J. Victor Garcia
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/429cd19f878a43bfbfa8e6f41fa82d27
Autor:
Yuyang Tang, Antoine Chaillon, Sara Gianella, Lilly M. Wong, Dajiang Li, Theresa L. Simermeyer, Magali Porrachia, Caroline Ignacio, Brendon Woodworth, Daniel Zhong, Jiayi Du, Eduardo de la Parra Polina, Jennifer Kirchherr, Brigitte Allard, Matthew L. Clohosey, Matt Moeser, Amy L. Sondgeroth, Gregory D. Whitehill, Vidisha Singh, Amir Dashti, Davey M. Smith, Joseph J. Eron, Katherine J. Bar, Ann Chahroudi, Sarah B. Joseph, Nancie M. Archin, David M. Margolis, Guochun Jiang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Brain microglia (MG) may serve as a human immunodeficiency virus 1 (HIV) reservoir and ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet to be proven to harbor replication-competent HIV. Here, we isolated b
Externí odkaz:
https://doaj.org/article/2b445d2797e54b559239027e8348ce19
Autor:
Dajiang Li, Lilly M. Wong, Yuyang Tang, Brigitte Allard, Katherine S. James, George R. Thompson, Satya Dandekar, Edward P. Browne, Qingsheng Li, Jeremy M. Simon, Nancie M. Archin, David M. Margolis, Guochun Jiang
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105743- (2023)
Summary: HIV reservoirs are extremely stable and pose a tremendous challenge to clear HIV infection. Here, we demonstrate that activation of ISR/ATF4 signaling reverses HIV latency, which also selectively eliminates HIV+ cells in primary CD4+ T cell
Externí odkaz:
https://doaj.org/article/4754676d264e4d7cbf4fe632cfa2482d
Autor:
Shane D. Falcinelli, Alicia Volkheimer, Lesia Semenova, Ethan Wu, Alexander Richardson, Manickam Ashokkumar, David M Margolis, Nancie M. Archin, Cynthia D Rudin, David Murdoch, Edward P Browne
Publikováno v:
Journal of Virus Eradication, Vol 8, Iss , Pp 100232- (2022)
Externí odkaz:
https://doaj.org/article/20c02bfeaa394bd99796ae4c29d0cb99
Autor:
Shane D. Falcinelli, Jackson J. Peterson, Anne-Marie W. Turner, David Irlbeck, Jenna Read, Samuel L.M. Raines, Katherine S. James, Cameron Sutton, Anthony Sanchez, Ann Emery, Gavin Sampey, Robert Ferris, Brigitte Allard, Simon Ghofrani, Jennifer L. Kirchherr, Caroline Baker, JoAnn D. Kuruc, Cynthia L. Gay, Lindsey I. James, Guoxin Wu, Paul Zuck, Inmaculada Rioja, Rebecca C. Furze, Rab K. Prinjha, Bonnie J. Howell, Ronald Swanstrom, Edward P. Browne, Brian D. Strahl, Richard M. Dunham, Nancie M. Archin, David M. Margolis
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity during suppressive antiretroviral therapy (ART). However, full ta
Externí odkaz:
https://doaj.org/article/4373bee6f4264a5fa37799577488e1df
Autor:
Dajiang Li, Morgan G. Dewey, Li Wang, Shane D. Falcinelli, Lilly M. Wong, Yuyang Tang, Edward P. Browne, Xian Chen, Nancie M. Archin, David M. Margolis, Guochun Jiang
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103649- (2022)
Summary: The eradication of HIV infection is difficult to achieve because of stable viral reservoirs. Here, we show that crotonylation enhances AZD5582-induced noncanonical NF-κB (ncNF-κB) signaling, further augmenting HIV latency reversal in Jurka
Externí odkaz:
https://doaj.org/article/40baf72d802e42f5b3fd5261a4846a4b
Autor:
Yinyan Xu, Ilana M. Trumble, Joanna A. Warren, Genevieve Clutton, Maria Abad-Fernandez, Jennifer Kirchnerr, Adaora A. Adimora, Steven G. Deeks, David M. Margolis, JoAnn D. Kuruc, Cynthia L. Gay, Nancie M. Archin, Katie R. Mollan, Michael Hudgens, Nilu Goonetilleke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 9-17 (2019)
HIV infection induces a robust T cell response that is sustained by high viremia, but falls following the onset of antiretroviral therapy (ART). Relatively little has been reported on the subsequent stability of the HIV-specific T cell response in in
Externí odkaz:
https://doaj.org/article/44f9792e661e44618554490798d4fdd3
Autor:
Erin L. Stuelke, Katherine S. James, Jennifer L. Kirchherr, Brigitte Allard, Caroline Baker, Joann D. Kuruc, Cindy L. Gay, David M. Margolis, Nancie M. Archin
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Quantifying the inducible HIV reservoir provides an estimate of the frequency of quiescent HIV-infected cells in humans as well as in animal models, and can help ascertain the efficacy of latency reversing agents (LRAs). The quantitative viral outgro
Externí odkaz:
https://doaj.org/article/094bbfff16464b2091f0d3b9f6dbf1e6
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
A cure for HIV infection remains elusive due to the persistence of replication-competent HIV proviral DNA during suppressive antiretroviral therapy (ART). With the exception of rare elite or post-treatment controllers of viremia, withdrawal of ART in
Externí odkaz:
https://doaj.org/article/6ac190cb08ca49fcbcab8136c0cab08b
Autor:
Julia A. Sung, Katherine Sholtis, Jennifer Kirchherr, Joann D. Kuruc, Cynthia L. Gay, Jeffrey L. Nordstrom, Catherine M. Bollard, Nancie M. Archin, David M. Margolis
Publikováno v:
EBioMedicine, Vol 23, Iss C, Pp 52-58 (2017)
Latently human immunodeficiency virus (HIV)-infected cells are transcriptionally quiescent and invisible to clearance by the immune system. To demonstrate that the latency reversing agent vorinostat (VOR) induces a window of vulnerability in the late
Externí odkaz:
https://doaj.org/article/a8c38440262542a9b672ae9ed2c48779