Halofuginone for non-hospitalized adult patients with COVID-19 a multicenter, randomized placebo-controlled phase 2 trial. The HALOS trial.

Autor: Bruno Martins Tomazini, Lucas Tramujas, Fernando Azevedo Medrado, Samara Pinheiro do Carmo Gomes, Karina Leal Negrelli, Gabriela Souza Murinize, Renato Hideo Nakagawa Santos, Bruna Martins Pereira Vianna, Bruna Fornazieri Piotto, Thabata Silva Veiga, Bianca Rodrigues do Santos, Ana Clara Peneluppi Horak, Olivia Mora Cavalcante Lemos, Marcela de Almeida Lopes, Beatriz Baptista Olicheski, Diego Lurentt Campones, Luiz Angelo Alencar Peixoto, Aline Dos Anjos Chaves Basilio, Otavio Celso Eluf Gebara, Ana Tarina Alvarez Lopes, Humberto Saconato, Nanci Valeis, Tamiris Abait Miranda, Ligia Nasi Laranjeira, Eliana Vieira Santucci, Aaron Foster Carlin, Jeffrey David Esko, Phillip Leo Stephan Marie Gordts, Sotirios Tsimikas, Alexandre Biasi Cavalcanti

Publikováno v: PLoS ONE, Vol 19, Iss 2, p e0299197 (2024)

BackgroundHalofuginone (PJS-539) is an oral prolyl-tRNA synthetase inhibitor that has a potent in vitro activity against SARS-CoV-2 virus. The safety and efficacy of halofuginone in Covid-19 patients has not been studied.MethodsWe conducted a phase I

Externí odkaz: https://doaj.org/article/8f9063cdddcc407b8037ccf8dcd06051

Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve

Autor: Helio P, Guimarães, Renato D, Lopes, Pedro G M, de Barros E Silva, Idelzuita L, Liporace, Roney O, Sampaio, Flávio, Tarasoutchi, Conrado R, Hoffmann-Filho, Rodrigo, de Lemos Soares Patriota, Tiago L L, Leiria, Diana, Lamprea, Dalton B, Precoma, Fernando A, Atik, Fabio S, Silveira, Fabio R, Farias, Diogo O, Barreto, Adail P, Almeida, Alexandre C, Zilli, João D, de Souza Neto, Margaret A, Cavalcante, Fernando A M S, Figueira, Flávia C S, Kojima, Lucas, Damiani, Renato H N, Santos, Nanci, Valeis, Viviane B, Campos, Jose F K, Saraiva, Francisco H, Fonseca, Ibraim M, Pinto, Carlos C, Magalhães, Joao F M, Ferreira, John H, Alexander, Ricardo, Pavanello, Alexandre B, Cavalcanti, Otavio, Berwanger, Joima, Tobias

Publikováno v: New England Journal of Medicine. 383:2117-2126

The effects of rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve remain uncertain.In this randomized trial, we compared rivaroxaban (20 mg once daily) with dose-adjusted warfarin (target international normalized ratio,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89551d08a2baf22990ddd6212d2c443c
https://doi.org/10.1056/nejmoa2029603

IMPACTO-MR: a Brazilian nationwide platform study to assess infections and multidrug resistance in intensive care units

Autor: Bruno M. Tomazini, Antonio Paulo Nassar Júnior, Thiago Costa Lisboa, Luciano César Pontes de Azevedo, Viviane Cordeiro Veiga, Daniela Ghidetti Mangas Catarino, Debora Vacaro Fogazzi, Beatriz Arns, Filipe Teixeira Piastrelli, Camila Dietrich, Karina Leal Negrelli, Isabella de Andrade Jesuíno, Luiz Fernando Lima Reis, Renata Rodrigues de Mattos, Carla Cristina Gomes Pinheiro, Mariane Nascimento Luz, Clayse Carla da Silva Spadoni, Elisângela Emilene Moro, Flávia Regina Bueno, Camila Santana Justo Cintra Sampaio, Débora Patrício Silva, Franca Pellison Baldassare, Ana Cecilia Alcantara Silva, Thabata Veiga, Leticia Barbante, Marianne Lambauer, Viviane Bezerra Campos, Elton Santos, Renato Hideo Nakawaga Santos, Ligia Nasi Laranjeiras, Nanci Valeis, Eliana Santucci, Tamiris Abait Miranda, Ana Cristina Lagoeiro do Patrocínio, Andréa de Carvalho, Eduvirgens Maria Couto de Sousa, Ancelmo Honorato Ferraz de Sousa, Daniel Tavares Malheiro, Isabella Lott Bezerra, Mirian Batista Rodrigues, Julliana Chicuta Malicia, Sabrina Souza da Silva, Bruna dos Passos Gimenes, Guilhermo Prates Sesin, Alexandre Prehn Zavascki, Daniel Sganzerla, Gregory Saraiva Medeiros, Rosa da Rosa Minho dos Santos, Fernanda Kelly Romeiro Silva, Maysa Yukari Cheno, Carolinne Ferreira Abrahão, Haliton Alves de Oliveira Junior, Leonardo Lima Rocha, Pedro Aniceto Nunes Neto, Valéria Chagas Pereira, Luis Eduardo Miranda Paciência, Elaine Silva Bueno, Eliana Bernadete Caser, Larissa Zuqui Ribeiro, Caio Cesar Ferreira Fernandes, Juliana Mazzei Garcia, Vanildes de Fátima Fernandes Silva, Alisson Junior dos Santos, Flávia Ribeiro Machado, Maria Aparecida de Souza, Bianca Ramos Ferronato, Hugo Corrêa de Andrade Urbano, Danielle Conceição Aparecida Moreira, Vicente Cés de Souza-Dantas, Diego Meireles Duarte, Juliana Coelho, Rodrigo Cruvinel Figueiredo, Fernanda Foreque, Thiago Gomes Romano, Daniel Cubos, Vladimir Miguel Spirale, Roberta Schiavon Nogueira, Israel Silva Maia, Cassio Luis Zandonai, Wilson José Lovato, Rodrigo Barbosa Cerantola, Tatiana Gozzi Pancev Toledo, Pablo Oscar Tomba, Joyce Ramos de Almeida, Luciana Coelho Sanches, Leticia Pierini, Mariana Cunha, Michelle Tereza Sousa, Bruna Azevedo, Felipe Dal-Pizzol, Danusa de Castro Damasio, Marina Peres Bainy, Dagoberta Alves Vieira Beduhn, Joana D’Arc Vila Nova Jatobá, Maria Tereza Farias de Moura, Leila Rezegue de Moraes Rego, Adria Vanessa da Silva, Luana Pontes Oliveira, Eliene Sá Sodré Filho, Silvana Soares dos Santos, Itallo de Lima Neves, Vanessa Cristina de Aquino Leão, João Lucidio Lobato Paes, Marielle Cristina Mendes Silva, Cláudio Dornas de Oliveira, Raquel Caldeira Brant Santiago, Jorge Luiz da Rocha Paranhos, Iany Grinezia da Silva Wiermann, Durval Ferreira Fonseca Pedroso, Priscilla Yoshiko Sawada, Rejane Martins Prestes, Glícia Cardoso Nascimento, Cintia Magalhães Carvalho Grion, Claudia Maria Dantas de Maio Carrilho, Roberta Lacerda Almeida de Miranda Dantas, Eliane Pereira Silva, Antônio Carlos da Silva, Sheila Mara Bezerra de Oliveira, Nicole Alberti Golin, Rogerio Tregnago, Valéria Paes Lima, Kamilla Grasielle Nunes da Silva, Emerson Boschi, Viviane Buffon, André Sant’Ana Machado, Leticia Capeletti, Rafael Botelho Foernges, Andréia Schubert de Carvalho, Lúcio Couto de Oliveira Junior, Daniela Cunha de Oliveira, Everton Macêdo Silva, Julival Ribeiro, Francielle Constantino Pereira, Fernanda Borges Salgado, Caroline Deutschendorf, Cristofer Farias da Silva, Andre Luiz Nunes Gobatto, Carolaine Bomfim de Oliveira, Marianna Deway Andrade Dracoulakis, Natália Oliveira Santos Alvaia, Roberta Machado de Souza, Larissa Liz Cardoso de Araújo, Rodrigo Morel Vieira de Melo, Luiz Carlos Santana Passos, Claudia Fernanda de Lacerda Vidal, Fernanda Lopes de Albuquerque Rodrigues, Pedro Kurtz, Cássia Righy Shinotsuka, Maria Brandão Tavares, Igor das Virgens Santana, Luciana Macedo da Silva Gavinho, Alaís Brito Nascimento, Adriano J. Pereira, Alexandre Biasi Cavalcanti

Publikováno v: Revista Brasileira de Terapia Intensiva. 34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac025f19f9f11af03e7114eac14e5157
https://doi.org/10.5935/0103-507x.20220209-en

Ticagrelor versus clopidogrel after fibrinolytic therapy in patients with ST-elevation myocardial infarction: Rationale and design of the ticagrelor in patients with ST elevation myocardial infarction treated with thrombolysis (TREAT) trial

Autor: Otavio Berwanger, Shaun G. Goodman, Diogo D.F. Moia, José Francisco Kerr Saraiva, Stephen J. Nicholls, Oleg Averkov, Germán Málaga, Camila M. R. Lasagno, Christopher B. Granger, Lucas P. Damiani, Nanci Valeis, Leopoldo S. Piegas, Harvey D. White, Hélio Penna Guimarães, Renato D. Lopes, Carolina T. Candido, Jose C. Nicolau, Francisco Antonio Helfenstein Fonseca, Lixin Jiang, Antonio Carlos Carvalho, Carlos Tajer, Pedro Gabriel Melo de Barros e Silva, Alexander Parkhomenko, Denise M. Paisani

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background The safety and efficacy of ticagrelor in patients with ST-elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remain uncertain. Objectives The primary objective of the TicagRElor in pAtients with ST elevation myocardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d3d80a1e77bc52f372bd83591e8474
https://doi.org/10.1016/j.ahj.2018.02.017

Como garantir a autonomia do sujeito de pesquisa em estudos clínicos em pediatria?

Autor: Nanci Valeis, Sonia Mansoldo Dainesi, Mariana Bueno

Publikováno v: Revista da Associação Médica Brasileira, Volume: 52, Issue: 6, Pages: 382-383, Published: DEC 2006
Revista da Associação Médica Brasileira, Vol 52, Iss 6, Pp 382-383 (2006)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6c034f79dbf8b6c2b6e9efa7a8678e
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302006000600009&lng=en&tlng=en