Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nana-Maria Wagner"'
Autor:
Finnja Marie Zurek-Leffers, Florian Lehmann, Laura Brabenec, Sebastian Kintrup, Katharina E. M. Hellenthal, Kira Mersjann, Felicia Kneifel, Michael Hessler, Philip-Helge Arnemann, Tim-Gerald Kampmeier, Christian Ertmer, Patrick Kellner, Nana-Maria Wagner
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades. Animal models have been widely used f
Externí odkaz:
https://doaj.org/article/9cdf58be157e47a280820934947edbd1
Autor:
Juna-Lisa Knop, Natalie Burkard, Mahshid Danesh, Sebastian Kintrup, Thomas Dandekar, Mugdha Srivastava, Rebecca Springer, Matthias Hiermaier, Nana-Maria Wagner, Jens Waschke, Sven Flemming, Nicolas Schlegel
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108049- (2023)
Summary: Breakdown of endothelial barrier integrity determines organ dysfunction and outcome of patients with sepsis. Increased levels of soluble vascular endothelial (VE)-cadherin fragments (sVE-cadherin) have previously been linked with inflammatio
Externí odkaz:
https://doaj.org/article/b7ca474599744819a3b24f21ed44a516
A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents
Autor:
Shufang He, Vanessa O. Zambelli, Pritam Sinharoy, Laura Brabenec, Yang Bian, Freeborn Rwere, Rafaela C.R. Hell, Beatriz Stein Neto, Barbara Hung, Xuan Yu, Meng Zhao, Zhaofei Luo, Chao Wu, Lijun Xu, Katrin J. Svensson, Stacy L. McAllister, Creed M. Stary, Nana-Maria Wagner, Ye Zhang, Eric R. Gross
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Pain signals are relayed to the brain via a nociceptive system, and in rare cases, this nociceptive system contains genetic variants that can limit the pain response. Here, we questioned whether a human transient receptor potential vanilloid 1 (TRPV1
Externí odkaz:
https://doaj.org/article/37d0f51fb16d49a8b7cc88f9c3a78b93
Publikováno v:
Cells, Vol 11, Iss 12, p 1935 (2022)
Systemic inflammation can be triggered by infection, surgery, trauma or burns. During systemic inflammation, an overshooting immune response induces tissue damage resulting in organ dysfunction and mortality. Endothelial cells make up the inner linin
Externí odkaz:
https://doaj.org/article/961fa83986d54406bd0cb4860a9ee3cd
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1401 (2021)
The transient receptor potential (TRP) cation channel superfamily comprises more than 50 channels that play crucial roles in physiological processes. TRP channels are responsive to several exogenous and endogenous biomolecules, with aldehydes emergin
Externí odkaz:
https://doaj.org/article/e75c72fb664149f8a40467debda9f321
Autor:
Stefan Bergt, MD, Andrea Grub, MD, Steffen Wagner, MD, Hauke Engelke, MD, Gabriele Nöldge-Schomburg, MD, Brigitte Vollmar, MD, Jan P. Roesner, MD, Nana-Maria Wagner, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 2, Pp 149-159 (2017)
Summary: Cardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR) is associated with high mortality and poor neurological outcome. We compared the effects of pravastatin and simvastatin on survival and neurofunction in a murine model of CA
Externí odkaz:
https://doaj.org/article/b338c5831c814ea4ab0a2baae8efbf3e
Autor:
Stefan Bergt, Andrea Grub, Melanie Mueller, Rika Bajorat, Ivan Barilar, Brigitte Vollmar, Jan Patrick Roesner, Nana-Maria Wagner
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220404 (2019)
BackgroundPatients experiencing cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) often die or suffer from severe neurological impairment. Post resuscitation syndrome is characterized by a systemic inflammatory response. Toll-like receptor
Externí odkaz:
https://doaj.org/article/b00d203f70724924bb5f5520065faca4
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113554 (2014)
Protein Z (PZ) is a vitamin K-dependent coagulation factor without catalytic activity. Evidence points towards PZ as an independent risk factor for the occurrence of human peripheral arterial disease. However, the role of PZ in ischemia-driven angiog
Externí odkaz:
https://doaj.org/article/c5daf277213a4ef8a9ef713d92036221
Autor:
Stefan Bergt, Anne Güter, Andrea Grub, Nana-Maria Wagner, Claudia Beltschany, Sönke Langner, Andreas Wree, Steve Hildebrandt, Gabriele Nöldge-Schomburg, Brigitte Vollmar, Jan P Roesner
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74944 (2013)
BackgroundCardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR) is associated with poor survival rate and neurofunctional outcome. Toll-like receptor 2 (TLR2) plays an important role in conditions of sterile inflammation such as reperfu
Externí odkaz:
https://doaj.org/article/7dd9d7356e654418ad64ca0b9ac08a07
Autor:
Roman M. R. Olivier, Marcel Macke, Jennifer C. Müller, Lisa Schrader, Maria Eveslage, Marcel Rauer, Carola Wempe, Sven Martens, Alexander Zarbock, Nana-Maria Wagner, Uwe Karst, Deniz Y. Dogan, Andrea U. Steinbicker
Publikováno v:
Anesthesia & Analgesia. 136:578-587