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Paraquat-induced intracellular Zn2+ dysregulation causes dopaminergic degeneration in the substantia nigra, but not in the striatum

Autor: Haruna Tamura, Ryusuke Nishio, Nana Saeki, Misa Katahira, Hiroki Morioka, Haruna Tamano, Atsushi Takeda

Publikováno v: NeuroToxicology. 90:136-144

Parkinson's disease (PD) is characterized by a selective death of nigrostriatal dopaminergic neurons, while the difference in the vulnerability to the death between the substantia nigra pars compacta (SNpc) and the striatum is poorly understood. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b870f380fe7ea79c0a65750642f2fd2
https://doi.org/10.1016/j.neuro.2022.03.010

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Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats

Autor: Nana Saeki, Haruna Tamano, Azusa Takeuchi, Misa Katahira, Ryusuke Nishio, Haruna Tamura, Atsushi Takeda

Publikováno v: Plant foods for human nutrition (Dordrecht, Netherlands). 77(3)

Coriandrum sativum L. (coriander), which is an annual herb of the Apiaceae family, has been traditionally used as a remedy. Here we tested whether heated extract of coriander leaf protects nigral dopaminergic neurodegeneration after exposure to 6-hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966d85b04da24dad93ebc4df1fa6e83c
https://pubmed.ncbi.nlm.nih.gov/35922685

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Dehydroeffusol Pprevents Amyloid β1-42-mediated Hippocampal Neurodegeneration via Reducing Intracellular Zn2+ Toxicity

Autor: Atsushi Takeda, Yukino Tanaka, Mako Egawa, Aoi Shioya, Misa Katahira, Mako Takiguchi, Hiroki Ikeda, Nana Saeki, Toshiyuki Fukuda, Haruna Tamano

Publikováno v: Molecular Neurobiology. 58:3603-3613

Dehydroeffusol, a phenanthrene isolated from Juncus effusus, is a Chinese medicine. To explore an efficacy of dehydroeffusol administration for prevention and cure of Alzheimer's disease, here we examined the effect of dehydroeffusol on amyloid β1-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fb99e468a13d1461a82aa8d61c6f94a
https://doi.org/10.1007/s12035-021-02364-3

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Autor: Misa Katahira, Nana Saeki, Haruna Tamano, Ryusuke Nishio, Azusa Takeuchi, Atsushi Takeda, Satoko Nakajima

Publikováno v: NeuroToxicology. 83:69-76

On the basis of the evidence that extracellular Zn2+ influx induced with AMPA causes Parkinson's syndrome in rats that apomorphine-induced movement disorder emerges, here we used a low dose of AMPA, which does not increase intracellular Zn2+ level in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::455816db83eb0a555ef3f96cc19ddf43
https://doi.org/10.1016/j.neuro.2020.12.014

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