Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Nana Rokutanda"'
Publikováno v:
BioTechniques, Vol 45, Iss 4, Pp 445-448 (2008)
Electrophoretic mobility shift assays (EMSAs) are commonly used to investigate protein-DNA binding in vitro. However, EMSA can generate considerable amounts of undesirable waste, particularly when toxic compounds are examined. We therefore developed
Externí odkaz:
https://doaj.org/article/f38fd9a7a0da4ca38aaeafdd3a5b8c0e
Autor:
Tomohiko Ohta, Keiji Tanaka, Yasushi Saeki, Nao Suzuki, Yasuo Miyoshi, Naoko Arai, Hiroyuki Nishikawa, Yukiko Togashi, Reo Maruyama, Yongqiang Lai, Jun Takeuchi, Nana Rokutanda, Wenwen Wu
Affinity purification of HERC2 complex and Mass Spectrometry; Sister chromatid exchange (SCE) assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b1ea69a2808edd2c001a244535b56b
https://doi.org/10.1158/0008-5472.22419297
https://doi.org/10.1158/0008-5472.22419297
Autor:
Tomohiko Ohta, Keiji Tanaka, Yasushi Saeki, Nao Suzuki, Yasuo Miyoshi, Naoko Arai, Hiroyuki Nishikawa, Yukiko Togashi, Reo Maruyama, Yongqiang Lai, Jun Takeuchi, Nana Rokutanda, Wenwen Wu
BLM and WRN are RecQ DNA helicasesessential for genomic stability. Here, we demonstrate that HERC2, a HECT E3 ligase, is critical for their functions to suppress G-quadruplex (G4) DNA. HERC2 interacted with BLM, WRN, and replication protein A (RPA) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e9eac19cc2c030815aa3c718868c1f6
https://doi.org/10.1158/0008-5472.c.6510345.v1
https://doi.org/10.1158/0008-5472.c.6510345.v1
Autor:
Tomohiko Ohta, Keiji Tanaka, Yasushi Saeki, Nao Suzuki, Yasuo Miyoshi, Naoko Arai, Hiroyuki Nishikawa, Yukiko Togashi, Reo Maruyama, Yongqiang Lai, Jun Takeuchi, Nana Rokutanda, Wenwen Wu
S1. Analyses of HERC2 complex immunoprecipitated with a newly generated antibody; S2. HERC2 regulates BLM-RPA complex formation; S3. Effect of HERC2 depletion on BLM-RPA and WRN-RPA complex formation was reproduced with a different shRNA; S4. Detecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a010b84259e21051bead3bef6df18aa6
https://doi.org/10.1158/0008-5472.22419300.v1
https://doi.org/10.1158/0008-5472.22419300.v1
Autor:
Do-Youn Oh, Aiwu Ruth He, Shukui Qin, Li-Tzong Chen, Takuji Okusaka, Arndt Vogel, Jin Won Kim, Thatthan Suksombooncharoen, Myung Ah Lee, Masayuki Kitano, Howard Burris, Mohamed Bouattour, Suebpong Tanasanvimon, Mairéad G. McNamara, Renata Zaucha, Antonio Avallone, Benjamin Tan, Juan Cundom, Choong-kun Lee, Hidenori Takahashi, Masafumi Ikeda, Jen-Shi Chen, Julie Wang, Mallory Makowsky, Nana Rokutanda, Philip He, John F. Kurland, Gordon Cohen, Juan W. Valle
Publikováno v:
NEJM Evidence. 1
Autor:
Aiwu Ruth He, Benjamin R. Tan, Thatthan Suksombooncharoen, Hidenori Takahashi, Ming-Huang Chen, Vikas S Ostwal, Sang Cheul Oh, Emel Sezer, Piotr Potemski, Kun-Ming Rau, Ekaphop Sirachainan, Junhe Li, Jean-Frédéric Blanc, Gordon Cohen, Magdalena Żotkiewicz, Nana Rokutanda, Do-Youn Oh
Publikováno v:
Journal of Clinical Oncology. 41:550-550
550 Background: TOPAZ-1 (NCT03875235) is a double-blind, Phase 3 study of durvalumab (D), an immune checkpoint inhibitor (ICI), + gemcitabine and cisplatin (GC) in participants (pts) with advanced biliary tract cancer (BTC). D + GC improved overall s
Autor:
Chad Gwaltney, Xandra Lie, Afsaneh Barzi, Melinda Bachini, Oren Meyers, Makoto Ueno, Nana Rokutanda, Teresa Macarulla, Nikunj Patel, Christina Workman, G. Cohen, Davide Melisi, Seung Tae Kim
Publikováno v:
Scientia
Oncology and Therapy
Oncology and Therapy
Cáncer del tracto biliar; Estudio de entrevista; Investigación cualitativa Càncer del tracte biliar; Estudi d'entrevista; Recerca qualitativa Biliary tract cancer; Interview study; Qualitative research Introduction Patients living with biliary tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6cef5b8fc2123ea42e914d370c394a
https://hdl.handle.net/11351/7335
https://hdl.handle.net/11351/7335
Autor:
Nana Rokutanda, Tomohiko Ohta, Yongqiang Lai, Yukiko Togashi, Mingzhang Zhu, Wenwen Wu, Weixin Liang
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Replication protein A (RPA) binds to and stabilizes single-stranded DNA and is essential for the genome stability. We reported that an E3 ubiquitin ligase, HERC2, suppresses G-quadruplex (G4) DNA by regulating RPA-helicase complexes. However, the pre
Autor:
Do-Youn Oh, Aiwu Ruth He, Shukui Qin, Li-Tzong Chen, Takuji Okusaka, Arndt Vogel, Jin Won Kim, Thatthan Suksombooncharoen, Myung Ah Lee, Masayuki Kitano, Howard A. Burris III, Mohamed Bouattour, Suebpong Tanasanvimon, Renata Zaucha, Antonio Avallone, Juan Cundom, Nana Rokutanda, Julia Xiong, Gordon Cohen, Juan W. Valle
Publikováno v:
Journal of Clinical Oncology. 40:378-378
378 Background: BTC is a rare, heterogenous cancer with poor prognosis. Reports on immunogenic features of BTC suggest checkpoint inhibition may result in antitumor immune responses, and limited clinical activity has been seen with single agents in a
Autor:
Hiroki Odawara, Mami Kikuchi, Jun Horiguchi, Hideaki Tokiniwa, A. Sato, Nana Rokutanda, Daisuke Takata, Rin Nagaoka, Izumi Takeyoshi
Background: S-1 and cyclophosphamide (CPA) can be given orally, and their combination may have great potential for treating metastatic breast cancer (MBC). A phase I study of sequential S-1 and CPA therapy was conducted in patients with MBC; the reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80e5c481c93f3cbbcfe7e0eaf1421087
https://doi.org/10.21203/rs.3.rs-22934/v3
https://doi.org/10.21203/rs.3.rs-22934/v3