Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

Autor: Lei Liu, Nana Bartke, Hans Van Daele, Peter Lawrence, Xia Qin, Hui Gyu Park, Kumar Kothapalli, Anthony Windust, Jacques Bindels, Zhe Wang, J. Thomas Brenna

Publikováno v: Journal of Lipid Research, Vol 55, Iss 3, Pp 531-539 (2014)

Long-chain PUFAs (LCPUFAs) occur in foods primarily in the natural lipid classes, triacylglycerols (TAGs) or phospholipids (PLs). We studied the relative efficacy of the neural omega-3 DHA provided in formula to growing piglets as a dose of 13C-DHA b

Externí odkaz: https://doaj.org/article/964024ab57424f5f941c30a90ab07a05

Bioactive sphingolipids: metabolism and function

Autor: Nana Bartke, Yusuf A. Hannun

Publikováno v: Journal of Lipid Research, Vol 50, Iss , Pp S91-S96 (2009)

Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural roles in cellular membranes, some metabolites, including ceramide, sphingosine, and sphingosine-1-phosphate, have drawn attention as bioactive signaling mo

Externí odkaz: https://doaj.org/article/a6bfef5d48c04b8d8960e624de75f648

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Autor: Rohan Maini, Yusuf A. Hannun, Achraf A. Shamseddine, Michael V. Airola, Miguel Garcia-Diaz, Nana Bartke, Lina M. Obeid, Can E. Senkal, Prajna Shanbhogue, Kip E. Guja, Bill X. Wu

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(28)

Neutral sphingomyelinase 2 (nSMase2, product of the SMPD3 gene) is a key enzyme for ceramide generation that is involved in regulating cellular stress responses and exosome-mediated intercellular communication. nSMase2 is activated by diverse stimuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86ae2e23ec397df1166769b933fe4fa
https://pubmed.ncbi.nlm.nih.gov/28652336

Effect of dietary intervention to reduce the n-6/n-3 fatty acid ratio on maternal and fetal fatty acid profile and its relation to offspring growth and body composition at 1 year of age

Autor: Monika Brüderl, Stefanie Brunner, Günther Boehm, Bernard Bader, Christiane Vollhardt, Daniela Much, Daniela Schmid, Hans Hauner, Ulrike Amann-Gassner, Ellen Heimberg, Eva-Maria Sedlmeier, Nana Bartke

Publikováno v: European Journal of Clinical Nutrition. 67:282-288

Evidence is accumulating that the long-chain PUFA (LCPUFA) are associated with offspring growth and body composition. We investigated the relationship between LCPUFAs in red blood cells (RBCs) of pregnant women/breastfeeding mothers and umbilical cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4451b39ee4b590a545bfefbb4cca8a
https://doi.org/10.1038/ejcn.2013.2

Impact of fish oils on the outcomes of a mouse model of acute Pseudomonas aeruginosa pulmonary infection

Autor: Luce Sergent, Frédéric Gottrand, Emilie Caron, Alain Duhamel, Nana Bartke, Marie-Odile Husson, Jean-Luc Desseyn

Publikováno v: British Journal of Nutrition
British Journal of Nutrition, Cambridge University Press (CUP), 2015, 113 (2), pp.191-199. ⟨10.1017/S0007114514003705⟩
British Journal of Nutrition, 2015, 113 (2), pp.191-199. ⟨10.1017/S0007114514003705⟩

Pseudomonas aeruginosais an opportunistic Gram-negative bacterium that causes pneumonia in immunocompromised humans and severe pulmonary damage in patients with cystic fibrosis. Imbalanced fatty acid incorporation in membranes, including increased ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ee35b29f68aafc7150d4efdafbc1c4
https://hal.univ-lille.fr/hal-02178806/file/Caron2015BJNutr.pdf