Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Nana Ama A.S. Anang"'
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Abstract 4149: Anti-CTLA-4 generates memory T-cells with greater expansion and functionality than anti-PD-1
Autor: Stephen Mok, Nana-Ama A.S. Anang, James J. Mancuso, James P. Allison
Publikováno v: Cancer Research. 83:4149-4149
Blocking either cytotoxic T-lymphocyte antigen-4 (CTLA-4) or programmed cell death-1 (PD-1) pathway relieves the negative regulation of T-cells resulting in durable tumor rejection in patients with cancer and improved survival rate. However, it remai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45b3f936853ec24374fb6d6c0d2241ba
https://doi.org/10.1158/1538-7445.am2023-4149
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A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention
Autor: Margaret L Axelrod, Bjorn C. Knollmann, Lauren I.R. Ehrlich, Justin M. Balko, Joe-Elie Salem, James P. Allison, Javid Moslehi, Jing Wang, Padmanee Sharma, Nana Ama A.S. Anang, Jayashree Srinivasan, James J. Mancuso, Oluwatomisin T. Atolagbe, Elles M. Screever, Wouter C. Meijers, Elizabeth M. Whitley, Lorenz H. Lehmann, Lauren E. Himmel, Matthew Wleklinski, Pierre-Yves Courand, Elizabeth Wescott, Bénédicte Lebrun-Vignes, Douglas B. Johnson, Xiayu Rao, Yu Li, Spencer C. Wei, Yang Zhao
Publikováno v: Cancer Discovery
Cancer Discovery, American Association for Cancer Research, 2020, pp.CD-20-0856. ⟨10.1158/2159-8290.CD-20-0856⟩
Cancer Discov
Cancer Discovery, American Association for Cancer Research, 2020, ⟨10.1158/2159-8290.CD-20-0856⟩
Immune checkpoint inhibitors (ICI) targeting CTLA4 or PD-1/PD-L1 have transformed cancer therapy but are associated with immune-related adverse events, including myocarditis. Here, we report a robust preclinical mouse model of ICI-associated myocardi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c070a4fc8d4961377f7fa500b86553f
https://hal.sorbonne-universite.fr/hal-03099615
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5
Combination anti-CTLA-4 plus anti-PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies
Autor: Jennifer A. Wargo, Alexandria P. Cogdill, Alexandre Reuben, James J. Mancuso, Spencer C. Wei, Dana Pe'er, James P. Allison, Jacob H. Levine, Nana Ama A.S. Anang, Roshan Sharma, Miles C. Andrews
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance Immune checkpoint blockade therapy has become a critical pillar of cancer therapy. Here, we characterize the cellular mechanisms of monotherapy and combination anti–cytotoxic T lymphocyte antigen-4 plus anti–programmed cell death-1 t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b9e1b025d70a2deca5de5d0c37d766
https://pubmed.ncbi.nlm.nih.gov/31636208
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6
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States
Autor: Jing Wang, Nana Ama A.S. Anang, James J. Mancuso, Dana Pe'er, Padmanee Sharma, Jacob H. Levine, Spencer C. Wei, Roshan Sharma, James P. Allison, Yang Zhao, Manu Setty
Publikováno v: Immunity. 50(4)
Summary Co-stimulation regulates T cell activation, but it remains unclear whether co-stimulatory pathways also control T cell differentiation. We used mass cytometry to profile T cells generated in the genetic absence of the negative co-stimulatory
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2e4e66d827a98fa240f444668eb732
https://pubmed.ncbi.nlm.nih.gov/30926234
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7
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
Autor: Yang Zhao, Miles C. Andrews, Jennifer A. Wargo, Dana Pe'er, Alexandria P. Cogdill, Jing Wang, Jacob H. Levine, James P. Allison, Padmanee Sharma, Spencer C. Wei, Nana Ama A.S. Anang
Publikováno v: Cell. 170(6)
Immune-checkpoint blockade is able to achieve durable responses in a subset of patients; however, we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4- and anti-PD-1-induced tumor rejection. To address these issues, we utili
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82259fb066a0d672225b88500377dc6a
https://pubmed.ncbi.nlm.nih.gov/28803728
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Abstract A205: Effects of anti-CTLA-4 and anti-PD-1 on memory T-cell differentiation and resistance to tumor relapse
Autor: Nana Ama A.S. Anang, Stephen Mok, Colm R. Duffy, James P. Allison
Publikováno v: Cancer Immunology Research. 7:A205-A205
Both anti-CTLA-4 and anti-PD-1 mediate significant response rates in cancer patients. As a hallmark of successful immunotherapies, they also mediate durable responses that last for years. For example, anti-CTLA-4 mediates a 22% 10-year overall surviv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ac06bd9ee96c6033fb5b9bed3874064
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a205
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