Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis

Autor: Nan W. Hultgren, Jennifer S. Fang, Mary E. Ziegler, Ricardo N. Ramirez, Duc T. T. Phan, Michaela M. S. Hatch, Katrina M. Welch-Reardon, Antonio E. Paniagua, Lin S. Kim, Nathan N. Shon, David S. Williams, Ali Mortazavi, Christopher C. W. Hughes

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through

Externí odkaz: https://doaj.org/article/8e37d57515834f55b45498858d31ca32

The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells

Autor: Srinivasa T. Reddy, David S. Williams, Eleni Ritou, Sharma Madhav, Anton Petcherski, Ellen I O’Connor, Nan W. Hultgren, Hugo Cristelle, Theodoros Kelesidis, Orian S. Shirihai

Publikováno v: Virulence
article-version (VoR) Version of Record
Virulence, Vol 12, Iss 1, Pp 2214-2227 (2021)
Virulence, vol 12, iss 1

An oral antiviral against SARS-CoV-2 that also attenuates inflammatory instigators of severe COVID-19 is not available to date. Herein, we show that the apoA-I mimetic peptide 4 F inhibits Spike mediated viral entry and has antiviral activity against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8632324e5cc9d708ead80a93caa78cd5
http://europepmc.org/articles/PMC8437485

Consensus guidelines for the use and interpretation of angiogenesis assays

Autor: Marcus Fruttiger, Mark J. Post, Andrey Anisimov, Robert S. Kerbel, Jan Kitajewski, Federico Bussolino, Sarah-Maria Fendt, Neil Dufton, Dai Fukumura, Agnès Noël, Raghu Kalluri, Johannes Waltenberger, Roberto Pili, Anna Dimberg, David O. Bates, Koen Marien, Victor W.M. van Hinsbergh, Peter Carmeliet, Andreas Bikfalvi, Curzio Rüegg, Hong Xin, Rakesh K. Jain, Hellmut G. Augustin, Robert Auerbach, Anna M. Randi, Jimmy Stalin, Bahar Yetkin-Arik, Gabriele Bergers, Stefan Schulte-Merker, Napoleone Ferrara, Paul H.A. Quax, Elisabeth Kuczynski, M. Luisa Iruela-Arispe, Judy R. van Beijnum, R. Hugh F. Bender, Elizabeth Allen, Ruud P.M. Dings, Anca Maria Cimpean, Joanna Kalucka, Andrew C. Dudley, Brant M. Weinstein, Lance L. Munn, Barbara C. Böck, Yan Gong, Jonathan W. Song, Lois E.H. Smith, Alfred C. Aplin, Steven A. Stacker, Jussi Nurro, Nan W. Hultgren, Anna-Karin Olsson, Bart Ghesquière, Peter C. Brooks, Adrian L. Harris, Joyce Bischoff, Juan M. Melero-Martin, Reinier O. Schlingemann, Hynda K. Kleinmann, Amber N. Stratman, Gabriel A. Rabinovich, Pieter Koolwijk, Patrycja Nowak-Sliwinska, Robert J. Griffin, Marius Raica, Mervin C. Yoder, Daniel Castranova, Roberto F. Nicosia, Seppo Ylä-Herttuala, Bertan Cakir, Peter B. Vermeulen, George E. Davis, Christopher C.W. Hughes, Tatiana V. Petrova, Maureen Van de Velde, George Coukos, Jeffrey W. Pollard, Kari Alitalo, Valentin Djonov, Kristian Pietras, Ondine Cleaver, Domenico Ribatti, Melita Irving, Brenda R. Kwak, Arjan W. Griffioen, Michele De Palma, Ingeborg Klaassen

Publikováno v: Nowak-Sliwinska, P, Alitalo, K, Allen, E, Anisimov, A, Aplin, A C, Auerbach, R, Augustin, H G, Bates, D O, van Beijnum, JR, Bender, R HF, Bergers, G, Bikfalvi, A, Bischoff, J, Böck, BC, Brooks, PC, Bussolino, F, Cakir, B, Carmeliet, P, Castranova, D, Cimpean, AM, Cleaver, O, Coukos, G, Davis, GE, De Palma, M, Dimberg, A, Dings, RP M, Djonov, V, Dudley, AC, Dufton, NP, Fendt, S-M, Ferrara, N, Fruttiger, M, Fukumura, D, Ghesquière, B, Gong, Y, Griffin, RJ, Harris, AL, Hughes, CC W, Hultgren, NW, Iruela-Arispe, M L, Irving, M, Jain, RK, Kalluri, R, Kalucka, J, Kerbel, RS, Kitajewski, J, Klaassen, I, Kleinmann, HK, Koolwijk, P, Kuczynski, E, Kwak, BR, Marien, K, Melero-Martin, JM, Munn, LL, Nicosia, RF, Noel, A, Nurro, J, Olsson, A-K, Petrova, TV, Pietras, K, Pili, R, Pollard, J, Post, MJ, Quax, PH A, Rabinovich, GA, Raica, M, Randi, AM, Ribatti, D, Ruegg, C, Schlingemann, RO, Schulte-Merker, S, Smith, LE H, Song, JW, Stacker, SA, Stalin, J, Stratman, AN, Van de Velde, M, van Hinsbergh, VW M, Vermeulen, PB, Waltenberger, J, Weinstein, BM, Xin, H, Yetkin-Arik, B, Yla-Herttuala, S, Yoder, MC & Griffioen, AW 2018, ' Consensus guidelines for the use and interpretation of angiogenesis assays ', Angiogenesis . https://doi.org/10.1007/s10456-018-9613-x
Angiogenesis, vol 21, iss 3
Angiogenesis
Nowak-Sliwinska, P, Alitalo, K, Allen, E, Anisimov, A, Aplin, A C, Auerbach, R, Augustin, H G, Bates, D O, van Beijnum, J R, Bender, R H F, Bergers, G, Bikfalvi, A, Bischoff, J, Böck, B C, Brooks, P C, Bussolino, F, Cakir, B, Carmeliet, P, Castranova, D, Cimpean, A M, Cleaver, O, Coukos, G, Davis, G E, De Palma, M, Dimberg, A, Dings, R P M, Djonov, V, Dudley, A C, Dufton, N P, Fendt, S-M, Ferrara, N, Fruttiger, M, Fukumura, D, Ghesquière, B, Gong, Y, Griffin, R J, Harris, A L, Hughes, C C W, Hultgren, N W, Iruela-Arispe, M L, Irving, M, Jain, R K, Kalluri, R, Kalucka, J, Kerbel, R S, Kitajewski, J, Klaassen, I, Kleinmann, H K, Koolwijk, P, Kuczynski, E, Kwak, B R, Marien, K, Melero-Martin, J M, Munn, L L, Nicosia, R F, Noel, A, Nurro, J, Olsson, A-K, Petrova, T V, Pietras, K, Pili, R, Pollard, J W, Post, M J, Quax, P H A, Rabinovich, G A, Raica, M, Randi, A M, Ribatti, D, Ruegg, C, Schlingemann, R O, Schulte-Merker, S, Smith, L E H, Song, J W, Stacker, S A, Stalin, J, Stratman, A N, Van de Velde, M, van Hinsbergh, V W M, Vermeulen, P B, Waltenberger, J, Weinstein, B M, Xin, H, Yetkin-Arik, B, Yla-Herttuala, S, Yoder, M C & Griffioen, A W 2018, ' Consensus guidelines for the use and interpretation of angiogenesis assays ', Angiogenesis, vol. 21, no. 3, pp. 425-532 . https://doi.org/10.1007/s10456-018-9613-x
Angiogenesis, vol. 21, no. 3, pp. 425-532
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Angiogenesis, Vol. 21, No 3 (2018) P. 425–532
Nowak-Sliwinska, Patrycja; Alitalo, Kari; Allen, Elizabeth; Anisimov, Andrey; Aplin, Alfred C; Auerbach, Robert; Augustin, Hellmut G; Bates, David O; van Beijnum, Judy R; Bender, R Hugh F; Bergers, Gabriele; Bikfalvi, Andreas; Bischoff, Joyce; Böck, Barbara C; Brooks, Peter C; Bussolino, Federico; Cakir, Bertan; Carmeliet, Peter; Castranova, Daniel; Cimpean, Anca M; ... (2018). Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis, 21(3), pp. 425-532. Springer Netherlands 10.1007/s10456-018-9613-x
Angiogenesis, 21(3), 425-532

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed64c3d8cb416fbc05945159373b70b
https://doi.org/10.1007/s10456-018-9613-x

Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria

Autor: Marc Liesa, Alexander M. van der Bliek, Nan W. Hultgren, Dane M. Wolf, David S. Williams, Mayuko Segawa, Orian S. Shirihai, David B. Shackelford

Publikováno v: Life Science Alliance

A novel, machine-learning approach to quantify cristae density and architecture in live-cell super-resolution imaging characterizes the ultrastructural parameters of individual mitochondria over time.
Recent breakthroughs in live-cell imaging ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb745a0b56c23f5f3810dc8f667fc78
https://doi.org/10.26508/lsa.201900620