Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nan Peng Chen"'
Publikováno v:
Science Advances, 9 (3), Art.-Nr.: eadd6982
Mitotic perturbations activate the spindle assembly checkpoint (SAC) that keeps cells in prometaphase with high CDK1 activity. Prolonged mitotic arrest is eventually bypassed by gradual cyclin B decline followed by slippage of cells into G 1 without
Publikováno v:
Nature Cell Biology
The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for cell rounding, mitotic retraction fibre formation, bipolar spindle positioning and chromosome segregation. The mechanism that drives FA disassembly at mito
Autor:
Thomas Ruppert, Manuel Weiß, Gislene Pereira, Elmar Schiebel, Robert Hardt, Patrick Partscht, Nan Peng Chen, Aliakbar Jafarpour, Bernd Heßling, Holger Lorenz, Borhan Uddin, Annett Neuner
Publikováno v:
EMBO Reports
CDC14A codes for a conserved proline-directed phosphatase, and mutations in the gene are associated with autosomal-recessive severe to profound deafness, due to defective kinocilia. A role of CDC14A in cilia formation has also been described in other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9f99ac24162bb1b31e970a615e40bd
https://europepmc.org/articles/PMC6322383/
https://europepmc.org/articles/PMC6322383/
Autor:
Uddin, Borhan1,2, Nan-Peng Chen1,2, Panic, Marko1,2, Schiebel, Elmar1 e.schiebel@zmbh.uni-heidelberg.de
Publikováno v:
BMC Genomics. 12/21/2015, Vol. 16, p1-10. 10p. 5 Diagrams.
Publikováno v:
Proceedings of the National Academy of Sciences. 113:990-995
Cell adhesion and migration are highly dynamic biological processes that play important roles in organ development and cancer metastasis. Their tight regulation by small GTPases and protein phosphorylation make interrogation of these key processes of
Publikováno v:
Current opinion in cell biology. 54
Integrin-mediated cell adhesion plays key roles for cell movement during development and tissue homeostasis. The dynamic life cycle of various integrin adhesions structures is required for the cell movements and regulated by the coordinated actions o
Autor:
Borhan Uddin, Elmar Schiebel, Robert Hardt, Thomas Ruppert, Patricia Kammerer, Ilaria Lucibello, Marko Panic, Nan-Peng Chen, Wen Ding
CDC14 is an essential dual-specificity phosphatase that counteracts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevisiae. Surprisingly, human CDC14A is not essential for cell cycle progression. Instead, it regulates cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a9757accb4751e95ea4b6e265a2168
https://europepmc.org/articles/PMC5441781/
https://europepmc.org/articles/PMC5441781/
Publikováno v:
BMC Genomics
Background Highly efficient genome editing can be achieved through targeting an endonuclease to specific locus of interest. Engineered zinc-finger nuclease (ZFN) and CRISPR-associated protein-9 nuclease (Cas9) offer such an elegant approach for genom
Publikováno v:
PROTEOMICS. 10:976-986
Genistein is a natural protein tyrosine kinase inhibitor that exerts anti-cancer effect by inducing G2/M arrest and apoptosis. However, the phosphotyrosine signaling pathways mediated by genistein are largely unknown. In this study, we combined tyros
Autor:
Qing-Yu He, Guang-Rong Yan, Nan-Peng Chen, Wen Ding, Yadong Huang, Gui-Wei He, Xing-Feng Yin, Chuan-Le Xiao
Publikováno v:
Journal of Proteomics & Bioinformatics. :113-120
Signaling molecules in signaling pathways proceed to be phosphorylated in the signal transmission from membrane receptors to nuclus. Dysregulated phosphorylation has been implicated in a variety of human diseases including cancer. In this study, we c