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Akademický článek

Efficacy and side effects of anti‐CD19 CAR T‐cell therapy in patients with relapsed/refractory gastrointestinal lymphoma

Autor: Yi Li Jiang, Juan Mu, Rui Cui, Xin Li, Jia Wang, Qing Li, Jingyi Li, Nan Mou, Qi Deng

Publikováno v: Cancer Medicine, Vol 13, Iss 4, Pp n/a-n/a (2024)

Abstract Introduction Although anti‐CD19 chimeric antigen receptor (CAR) T cell therapy was approved as a very effective salvage strategy in relapsed/refractory (R/R) B cell lymphoma, the experience in R/R gastrointestinal (GI) lymphoma is still in

Externí odkaz: https://doaj.org/article/9535177f35744ea48bd4af32d7204110

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Akademický článek

Targeting KRASG12V mutations with HLA class II-restricted TCR for the immunotherapy in solid tumors

Autor: Qi Ai, Fanlu Li, Siyi Zou, Zehui Zhang, Yangbing Jin, Lingxi Jiang, Hao Chen, Xiaxing Deng, Chenghong Peng, Nan Mou, Chenlei Wen, Baiyong Shen, Qian Zhan

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

KRAS mutation is a significant driving factor of tumor, and KRASG12V mutation has the highest incidence in solid tumors such as pancreatic cancer and colorectal cancer. Thus, KRASG12V neoantigen-specific TCR-engineered T cells could be a promising ca

Externí odkaz: https://doaj.org/article/b4dde58416184cff8635d96bf9bbd609

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Akademický článek

Donor Hematopoietic Stem Cell/Lymphocyte Maintenance Treatment After CAR T-Cell Therapy in Patients With B-Cell Acute Lymphoblastic Leukemia Relapse Following Stem Cell Transplant

Autor: Qing Li, Cuicui Lyu, Meijing Liu, Jia Wang, Nan Mou, Erlie Jiang, Rongli Zhang, Qi Deng

Publikováno v: Cell Transplantation, Vol 32 (2023)

Maintaining the efficacy of anti-CD19 chimeric antigen receptor modified (CAR) T-cell therapy in patients with B-cell acute lymphoblastic leukemia (B-ALL) relapse after allogeneic hematopoietic stem cell transplant (allo-HSCT) is an urgent problem. I

Externí odkaz: https://doaj.org/article/8fc340b8c4a1492abad9e9fb65330678

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Akademický článek

Cyclic RGD-Functionalized pH/ROS Dual-Responsive Nanoparticle for Targeted Breast Cancer Therapy

Autor: Pu Yao, Xiaowen Wang, Qianmei Wang, Qing Dai, Yu Peng, Qian Yuan, Nan Mou, Shan Lv, Bangbi Weng, Yu Wang, Fengjun Sun

Publikováno v: Pharmaceutics, Vol 15, Iss 7, p 1827 (2023)

Breast cancer is the most common malignant tumor in women and is a big challenge to clinical treatment due to the high morbidity and mortality. The pH/ROS dual-responsive nanoplatforms may be an effective way to significantly improve the therapeutic

Externí odkaz: https://doaj.org/article/f96b934e66fb4e639d966e2b975205e0

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Akademický článek

The expression and significance of efferocytosis and immune checkpoint related molecules in pancancer samples and the correlation of their expression with anticancer drug sensitivity

Autor: Lin Cheng, Bangbi Weng, Changsheng Jia, Lin Zhang, Bin Hu, Li Deng, Nan Mou, Fengjun Sun, Jing Hu

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: The efferocytosis-related molecules have been considered to be correlated with the resistance to cancer chemotherapy. The aim of this study was to investigate the expression and significance of efferocytosis-related molecules in cancers a

Externí odkaz: https://doaj.org/article/e61444f2a8894fc99024eab843ec8bc3

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Akademický článek

Intensive Debulking Chemotherapy Improves the Short-Term and Long-Term Efficacy of Anti-CD19-CAR-T in Refractory/Relapsed DLBCL With High Tumor Bulk

Autor: Cuicui Lyu, Rui Cui, Jia Wang, Nan Mou, Yanyu Jiang, Wei Li, Qi Deng

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Anti-CD19 chimeric antigen receptor T (CAR-T) therapy has achieved remarkable effects in refractory/relapsed (R/R) diffuse large B-cell lymphoma (DLBCL). However, when high tumor bulk occurs, patients tend to early progression after CAR-T therapy. He

Externí odkaz: https://doaj.org/article/5d88cca8d2e84e7b8401564b5ff765f7

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Akademický článek

Acute Graft-Versus-Host Disease After Humanized Anti-CD19-CAR T Therapy in Relapsed B-ALL Patients After Allogeneic Hematopoietic Stem Cell Transplant

Autor: Pengjiang Liu, Meijing Liu, Cuicui Lyu, Wenyi Lu, Rui Cui, Jia Wang, Qing Li, Nan Mou, Qi Deng, Donglin Yang

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

We studied the acute graft-versus-host disease (GVHD) after humanized anti-CD19-CAR T therapy in relapsed B-acute lymphoblastic leukemia (ALL) patients after allogeneic hematopoietic stem cell transplant (allo-HSCT). Fifteen B-ALL patients were enrol

Externí odkaz: https://doaj.org/article/a110b4d71ea04efbac9f9d3e2660c20c

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