Zobrazeno 1 - 10
of 2 109
pro vyhledávání: '"Nampt"'
Autor:
Yi-Fen Chiang, Ko-Chieh Huang, Tsui-Chin Huang, Hsin-Yuan Chen, Mohamed Ali, Ayman Al-Hendy, Pei-Shen Huang, Shih-Min Hsia
Publikováno v:
Redox Biology, Vol 78, Iss , Pp 103411- (2024)
Uterine leiomyoma (UL), commonly referred to as benign tumors, is characterized by excessive cell proliferation, extracellular matrix (ECM) accumulation, and the presence of stem cell-like properties. Nicotinamide adenine dinucleotide (NAD+) metaboli
Externí odkaz:
https://doaj.org/article/593bac45e12141c9921938543b405590
Publikováno v:
Brain Research Bulletin, Vol 218, Iss , Pp 111114- (2024)
Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme in the salvaging synthesize pathway of nicotinamide adenine dinucleotide (NAD). The neuroprotective roles of NAMPT on neurodegeneration have been explored in aging brain and Alzheimer
Externí odkaz:
https://doaj.org/article/0d85b6a07415459ea843515837291b95
Autor:
Zuoshi Wen, Liujun Jiang, Fangcong Yu, Xiaodong Xu, Mengjia Chen, Chenxi Li, Zhangquan Ying, Jianing Xue, Pengwei Zhu, Mairedan Muhetarijiang, Qingbo Xu, Zhoubin Li, Ting Chen
Publikováno v:
Interdisciplinary Medicine, Vol 2, Iss 4, Pp n/a-n/a (2024)
Abstract Phenotypic switching of smooth muscle cells (SMC) is a crucial process in the pathogenesis of pulmonary arterial hypertension (PAH). However, the underlying mechanism is unclear. Here, we performed single‐cell RNA sequencing on pulmonary a
Externí odkaz:
https://doaj.org/article/abcaacb335fb40bcbebfa0f1f86169ce
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway, and plays a vital role in the regulation of cell metabolic activity, reprogramming, aging and apoptosi
Externí odkaz:
https://doaj.org/article/81b3b13a67ad4c5dbb6960217f4670f5
Autor:
Luca Ponzone, Valentina Audrito, Claudia Landi, Enrico Moiso, Chiara Levra Levron, Sara Ferrua, Aurora Savino, Nicoletta Vitale, Massimiliano Gasparrini, Lidia Avalle, Lorenza Vantaggiato, Enxhi Shaba, Beatrice Tassone, Stefania Saoncella, Francesca Orso, Daniele Viavattene, Eleonora Marina, Irene Fiorilla, Giulia Burrone, Youssef Abili, Fiorella Altruda, Luca Bini, Silvia Deaglio, Paola Defilippi, Alessio Menga, Valeria Poli, Paolo Ettore Porporato, Paolo Provero, Nadia Raffaelli, Chiara Riganti, Daniela Taverna, Federica Cavallo, Enzo Calautti
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background The main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management of BRAF-mutated cutaneous metastatic melanoma (MM) is the development of therapeutic resistance. We aimed to assess in this context the
Externí odkaz:
https://doaj.org/article/18874da7221f495c92ee85e23df7d535
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 17, Pp 1809-1818 (2024)
Chao Zuo,1 Yi Liu,1 Ziqiang Wang,2 Jing Cheng,1 Dongli Yang,1 Huasong Gong,1 Yu Wang,3 Yongchao Qiao1 1Department of Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, People’s Republic of China; 2Research Cente
Externí odkaz:
https://doaj.org/article/706b451f43904a3e87ff2f72ff5a0541
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Nicotinamide adenine dinucleotide (NAD+) is crucial for cellular energy production, serving as a coenzyme in oxidation-reduction reactions. It also supports enzymes involved in processes such as DNA repair, aging, and immune responses. Lower NAD+ lev
Externí odkaz:
https://doaj.org/article/24b470737bb4476dbc02a1a1aefe2d6a
Autor:
Jialing Mu, Changying Chen, Zhanyun Ren, Fangyuan Liu, Xincheng Gu, Junxiang Sun, Yu Liu, Deqin Geng, Siyuan Yang, Qingqing Li, Lihua Liu, Lu Wang, Xuemei Chen, Hankun Xie, Chong Shen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 14 (2024)
Background Long noncoding RNA (lncRNA) and mRNA profiles in leukocytes have shown potential as biomarkers for acute ischemic stroke (AIS). This study aimed to identify altered lncRNA and target mRNA profiles in peripheral blood leukocytes as biomarke
Externí odkaz:
https://doaj.org/article/4163b99c37474135b9e283f2ca239916
Drugtamer‐PROTAC Conjugation Strategy for Targeted PROTAC Delivery and Synergistic Antitumor Therapy
Publikováno v:
Advanced Science, Vol 11, Iss 25, Pp n/a-n/a (2024)
Abstract Proteolysis‐targeting chimeras (PROTACs) have emerged as a promising strategy for targeted protein degradation and drug discovery. To overcome the inherent limitations of conventional PROTACs, an innovative drugtamer‐PROTAC conjugation a
Externí odkaz:
https://doaj.org/article/5e51af81a35342deaca83ed1f163fd7e