Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Namjin Chung"'
Autor:
Dike Qiu, Ke Xu, Namjin Chung, Jennifer Robbins, Robert Luo, Michael Lawrence, Aiqing He, Fei Yu, Andrew Alt, Michael M. Miller, Jon Hangeland, John N. Feder, Dietmar Seiffert, Brian J. Arey
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Vascular endothelial cells are exposed to mechanical forces due to their presence at the interface between the vessel wall and flowing blood. The patterns of these mechanical forces (laminar vs. turbulent) regulate endothelial cell function and play
Externí odkaz:
https://doaj.org/article/f3f3dd00eded4a689dfaf7ecdb19176f
Autor:
Ning Sun, Sakina Petiwala, Rui Wang, Charles Lu, Mufeng Hu, Sujana Ghosh, Yan Hao, Christopher P. Miller, Namjin Chung
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Large-scale genetic screening using CRISPR-Cas9 technology has emerged as a powerful approach to uncover and validate gene functions. The ability to control the timing of genetic perturbation during CRISPR screens will facilitate
Externí odkaz:
https://doaj.org/article/4b39644012e04178a8ae8b80c1b57d95
Autor:
Rui Wang, Sean Graham, Ning Sun, Donna McCarthy, Ruoqi Peng, Jamie Erickson, Liz Oconnor, Xiaochun Zhu, Marc Wurbel, Robert Dunstan, Susan Westmoreland, Namjin Chung, Tariq Ghayur, Jijie Gu
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0228221 (2020)
Inflammatory bowel diseases (IBD) are complex, multifactorial disorders characterized by chronic relapsing intestinal inflammation. IBD is diagnosed around 1 in 1000 individuals in Western countries with globally increasing incident rates. Associatio
Externí odkaz:
https://doaj.org/article/a04ed1706d0a49edb315c6d7dab23a95
Autor:
Willliam Conrad, Michael B Major, Michele A Cleary, Marc Ferrer, Brian Roberts, Shane Marine, Namjin Chung, William T Arthur, Randall T Moon, Jason D Berndt, Andy J Chien
Publikováno v:
F1000Research, Vol 2 (2013)
The inability of targeted BRAF inhibitors to produce long-lasting improvement in the clinical outcome of melanoma highlights a need to identify additional approaches to inhibit melanoma growth. Recent studies have shown that activation of the Wnt/β-
Externí odkaz:
https://doaj.org/article/ff1f05613bc44720a0cd8e4b015f5057
Autor:
Pingping Zheng, Shiming Ye, Enrico L. Digiammarino, Donghee Choi, Andrew V. Nguyen, Zoltan Dezso, Kathleen McGuire, Bryan M Rogers, Denny Nguyen, Sunantha Sethuraman, Gabriel R. Starbeck-Miller, Debra Chao, Xu Shi, Laura A. Smith, Namjin Chung, Dong Zhang, Wei Liu
Publikováno v:
The Journal of Experimental Medicine
VISTA biology has yet to be fully resolved despite much enthusiasm to define it as an immune checkpoint protein. Here, we show that VISTA antibodies can singly activate human monocytes and provide evidence that Syndecan-2 can regulate VISTA interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d40019dcf8a198d9775ec4d4d9f0000
http://europepmc.org/articles/PMC8193568
http://europepmc.org/articles/PMC8193568
Autor:
Min Hu, Ryan Duggan, Eric R. Goedken, Heath A. McDonald, Peter F. Slivka, J. Wetter, Marc H Domanus, Anthony Slavin, Sujatha M. Gopalakrishnan, Victoria E. Scott, Marian Namovic, Namjin Chung, Erin Murphy, John Locklear, Chen-Lin Hsieh, Charles Lu, Steven D. Pratt, Alex Lipovsky, Rebecca M. Edelmayer, Jacob King, Diana Donnelly-Roberts
Publikováno v:
ACS Chemical Biology. 14:857-872
Interleukin-17A (IL17A) plays a critical role in the development of numerous autoimmune diseases, including psoriasis. The clinical success of IL17A neutralizing biologics in psoriasis has underlined its importance as a drug discovery target. While m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e412ff837e5c673b8f22c55b9a72b01
https://doi.org/10.1021/acschembio.8b00260
https://doi.org/10.1021/acschembio.8b00260
Autor:
Robert Dunstan, Xiaochun Zhu, Donna McCarthy, Tariq Ghayur, Rui Wang, Edda Fiebiger, Namjin Chung, Jamie Erickson, Sean P. Graham, Marc Wurbel, Ning Sun, Jijie Gu, Ruoqi Peng
Inflammatory bowel diseases (IBD) are complex, multifactorial disorders characterized by chronic relapsing intestinal inflammation. Association studies have identified hundreds of genes that are linked to IBD and potentially regulate its pathology. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcf2ec68de4190113b09396c1b1e74a
Autor:
Ning Sun, Min Hu, Marc H Domanus, Mufeng Hu, Diya Mitra, Jessica E. Hutti, Miller Christopher P, Namjin Chung, Charles Lu, Sadiya N Addo, Sakina Petiwala
BackgroundGenome-wide CRISPR-Cas9 essentiality screening represents a powerful approach to identify genetic vulnerabilities in cancer cells. Here, we applied this technology and designed a strategy to identify target genes that are synthetic lethal (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83050179cf93c1b4da465cfabd469fb6
https://doi.org/10.1101/588707
https://doi.org/10.1101/588707
Autor:
Sun, Ning, Petiwala, Sakina, Wang, Rui, Lu, Charles, Mufeng Hu, Sujana Ghosh, Hao, Yan, Miller, Christopher, Namjin Chung
Figure S1. Schematic of drug-inducible sgRNA expression lentiviral vectors. Figure S2. Nucleotide sequence presentation of the DOX- and IPTG-inducible U6 promoter variants used in this study. The TATA box is underlined. TetO sequences are highlighted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660a23e81e15da9f70d045fe75f53d97
Autor:
Louis Locco, Pei Fen Kuan, Steven R. Bartz, Anthony Kreamer, Xiaohua Douglas Zhang, Namjin Chung, Marc Ferrer, Berta Strulovici, Peter S. Linsley
Publikováno v:
SLAS Discovery. 13:149-158
High-throughput screening (HTS) of large-scale RNA interference (RNAi) libraries has become an increasingly popular method of functional genomics in recent years. Cell-based assays used for RNAi screening often produce small dynamic ranges and signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a6e54fe2594d0ed8e22c6ee1dda83f
https://doi.org/10.1177/1087057107312035
https://doi.org/10.1177/1087057107312035