Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Namit, Ranjan"'
Autor:
Sakshi Jain, Lukasz Koziej, Panagiotis Poulis, Igor Kaczmarczyk, Monika Gaik, Michal Rawski, Namit Ranjan, Sebastian Glatt, Marina V. Rodnina
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract N6-methyladenosine (m6A) is an abundant, dynamic mRNA modification that regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding regions inhibits translation elongation. Here, we show how m6A modulates decoding in the bacteria
Externí odkaz:
https://doaj.org/article/56f48722b7584297a4c65b1c09193dce
Autor:
Meike Arend, Koray Ütkür, Harmen Hawer, Klaus Mayer, Namit Ranjan, Lorenz Adrian, Ulrich Brinkmann, Raffael Schaffrath
Publikováno v:
Microbial Cell, Vol 10, Iss 9, Pp 195-203 (2022)
In yeast, Elongator-dependent tRNA modifications are regulated by the Kti11•Kti13 dimer and hijacked for cell killing by zymocin, a tRNase ribotoxin. Kti11 (alias Dph3) also controls modification of elongation factor 2 (EF2) with diphthamide, the t
Externí odkaz:
https://doaj.org/article/cbab6fc1de5a40b2b53aba41197cf186
Autor:
Ying Zhang, Evelina De Laurentiis, Katherine E. Bohnsack, Mascha Wahlig, Namit Ranjan, Simon Gruseck, Philipp Hackert, Tina Wölfle, Marina V. Rodnina, Blanche Schwappach, Sabine Rospert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The guided entry of tail-anchored proteins (GET) pathway assists in the delivery of such proteins to the ER. Here, the authors reveal that the pathway components Get4/5 probe a region near the ribosomal exit tunnel. Upon emergence of a client protein
Externí odkaz:
https://doaj.org/article/96ddf33632654134a1b5c75874d99b55
Autor:
Sandra, Blanchet, Namit, Ranjan
Publikováno v:
Ribosome Biogenesis ISBN: 9781071625002
Methods Mol Biol
Methods Mol Biol
Protein synthesis in eukaryotes is carried out by 80S ribosomes with the help of many specific translation factors. Translation comprises four major steps: initiation, elongation, termination, and ribosome recycling. In this review, we provide a comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c53daee05d0a87da767f6653d33915
https://doi.org/10.1007/978-1-0716-2501-9_13
https://doi.org/10.1007/978-1-0716-2501-9_13
Autor:
Sandra, Blanchet, Namit, Ranjan
Publikováno v:
Ribosome Biogenesis ISBN: 9781071625002
Methods Mol Biol
Methods Mol Biol
Protein synthesis is an essential and highly regulated cellular process. To facilitate the understanding of eukaryotic translation, we have assembled an in vitro translation system from yeast using purified components to recapitulate the initiation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4ba6581bbcbee4efcc9b9f61ff72f8
https://doi.org/10.1007/978-1-0716-2501-9_16
https://doi.org/10.1007/978-1-0716-2501-9_16
Autor:
Bertrand Beckert, Namit Ranjan, Daniel N. Wilson, Agnieszka A. Pochopien, Colin Chih Chien Wu, Rachel Green, Sandra Blanchet, Marina V. Rodnina
Publikováno v:
The EMBO Journal
EMBO Journal
EMBO Journal
In addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and release at the ribosomal A and E sites, its exact mechanism of act
Autor:
Daniel N. Wilson, Rachel Green, Colin Chih Chien Wu, Sandra Blanchet, Marina V. Rodnina, Namit Ranjan, Bertrand Beckert, Agnieszka A. Pochopien
SummaryIn addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and release at the A and E sites, its exact mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8200af90d728397af75b075ac107fc3
https://doi.org/10.1101/2020.07.01.182105
https://doi.org/10.1101/2020.07.01.182105
Autor:
Marina V. Rodnina, Namit Ranjan
Publikováno v:
Journal of the American Chemical Society
Uridine 34 (U34) at the wobble position of the tRNA anticodon is post-transcriptionally modified, usually to mcm5s2, mcm5, or mnm5. The lack of the mcm5 or s2 modification at U34 of tRNALys, tRNAGlu, and tRNAGln causes ribosome pausing at the respect
Autor:
Sebastian A. Leidel, Namit Ranjan
Publikováno v:
Ranjan, Namit; Leidel, Sebastian A. (2019). The epitranscriptome in translation regulation: mRNA and tRNA modifications as the two sides of the same coin? FEBS letters, 593(13), pp. 1483-1493. FEBS Press 10.1002/1873-3468.13491
FEBS Letters
FEBS Letters
Translation of mRNA is a highly regulated process that is tightly coordinated with cotranslational protein maturation. Recently, mRNA modifications and tRNA modifications - the so called epitranscriptome - have added a new layer of regulation that is
Autor:
Jens Kretschmer, Katherine E. Sloan, Ahmed S. Warda, Namit Ranjan, Charlotte Blessing, Claudia Höbartner, Marina V. Rodnina, Peter Rehling, Sven Dennerlein, Markus T. Bohnsack, Benedikt Hübner, Sara Haag, Jan Seikowski
Publikováno v:
The EMBO Journal
Mitochondrial gene expression uses a non‐universal genetic code in mammals. Besides reading the conventional AUG codon, mitochondrial (mt‐)tRNAMet mediates incorporation of methionine on AUA and AUU codons during translation initiation and on AUA